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Modern Approach to Complex Arrhythmias, 2nd Edition
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Modern Approach to Complex Arrhythmias, 2nd Edition

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Electrophysiology and Cardiovascular Physiology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 813

Special Issue Editor

Prof. Dr. Matteo Bertini

E-Mail Website
Guest Editor
Cardiological Center, Translational Medicine Department, University of Ferrara, 944121 Ferrara, Italy
Interests: arrhythmias; PM; ICD; ablation; sudden cardiac death
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, several advancements have been made in the field of electrophysiology, and these are leading to changes in patient management. In particular, the use of zero-fluoroscopy, ultradensity mapping and new energy forms for complex arrhythmia ablation is increasing, conferring obvious advantages for patients.

This Special Issue will be focused on innovation in the field of electrophysiology, on the clinical relevance of novel methods acquired thus far, and on the near-future perspectives derived by changes in the management of patients.

Prof. Dr. Matteo Bertini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arrhythmias
  • ablation
  • zerofluorsocopy
  • ultra-density mapping
  • new energy forms

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Published Papers (2 papers)

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11 pages, 3100 KiB  
Article
A Hybrid Minimally Invasive Atrial Fibrillation Ablation Procedure Using Unilateral Thoracoscopy and Endocardial Pulsed Field Ablation: An Early Feasibility Study
by Ivan Eltsov, Luigi Pannone, Domenico Giovanni Della Rocca, Massimiliano Marini, Giacomo Talevi, Andrea Maria Paparella, Pasquale Vergara, Erwin Ströker, Juan Sieira, Gian-Battista Chierchia, Carlo de Asmundis and Mark La Meir
J. Cardiovasc. Dev. Dis. 2025, 12(4), 145; https://doi.org/10.3390/jcdd12040145 - 9 Apr 2025
Viewed by 318
Abstract
(1) Objective: To examine the efficiency and efficacy of using endovascular mapping and pulsed field ablation in the setting of a hybrid video-assisted thoracoscopic atrial fibrillation (AF) ablation procedure. (2) Methods: Eleven consecutive patients underwent hybrid video-assisted thoracoscopic epicardial ablation and left atrial [...] Read more.
(1) Objective: To examine the efficiency and efficacy of using endovascular mapping and pulsed field ablation in the setting of a hybrid video-assisted thoracoscopic atrial fibrillation (AF) ablation procedure. (2) Methods: Eleven consecutive patients underwent hybrid video-assisted thoracoscopic epicardial ablation and left atrial appendage exclusion followed by endocardial ablation using pulsed field ablation energy. The completeness of epicardial and endocardial lesion sets were assessed using 3D electro-anatomical mapping. (3) Results: Left atrial appendage (LAA) exclusion and durable pulmonary vein isolation (PVI) and posterior wall isolation (PWI) were achieved in all patients. The endovascular part of the necessary lesion set using PFA energy was successful in 100% of the patients. All patients remained in SR during the 12-month follow-up period. (4) Conclusions: Our study confirms the feasibility of using endovascular pulsed field ablation to complete previously performed epicardial lesion sets during the hybrid AF ablation procedures, without extending the procedure time or increasing the risk of complications. Full article
(This article belongs to the Special Issue Modern Approach to Complex Arrhythmias, 2nd Edition)
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11 pages, 5139 KiB  
Case Report
Dilated Cardiomyopathy: A Novel BAG3 Mutation Associated with Aggressive Disease Progression and Ventricular Arrhythmias
by Paolo Pastori, Cristina Balla, Marta Rasia, Emilia Lo Jacono, Clelia Guerra, Roberta Schininà, Francesca Gualandi, Matteo Bertini and Giovanni Tortorella
J. Cardiovasc. Dev. Dis. 2025, 12(4), 121; https://doi.org/10.3390/jcdd12040121 - 28 Mar 2025
Viewed by 212
Abstract
We present the case of a 46-year-old man with a history of complex ventricular arrhythmias preceding the development of asymptomatic mild left ventricular dysfunction, who presented with acute-onset heart failure and was ultimately diagnosed with dilated cardiomyopathy. Genetic testing identified a novel, likely [...] Read more.
We present the case of a 46-year-old man with a history of complex ventricular arrhythmias preceding the development of asymptomatic mild left ventricular dysfunction, who presented with acute-onset heart failure and was ultimately diagnosed with dilated cardiomyopathy. Genetic testing identified a novel, likely pathogenic mutation in exon 4 of the BAG3 gene (NM_004281, c.1128del, (p.(Ser377AlafsTer47)), not previously reported in the literature. Given the presence of multiple clinical features indicative of a poor prognosis, he underwent prophylactic placement of a subcutaneous implantable cardioverter-defibrillator. The clinical presentation of this novel BAG3 mutation suggests that it may be associated with a significant arrhythmic phenotype. This case underscores the importance of close follow-up and genetic testing in patients presenting with mild left ventricular dysfunction and ventricular arrhythmias. Full article
(This article belongs to the Special Issue Modern Approach to Complex Arrhythmias, 2nd Edition)
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