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67 Results Found

  • Review
  • Open Access
68 Citations
8,213 Views
18 Pages

Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review

  • Riccardo Di Fiore,
  • Sherif Suleiman,
  • Rosa Drago-Ferrante,
  • Yashwanth Subbannayya,
  • Francesca Pentimalli,
  • Antonio Giordano and
  • Jean Calleja-Agius

Cervical cancer (CC) is the fourth most common type of gynecological malignancy affecting females worldwide. Most CC cases are linked to infection with high-risk human papillomaviruses (HPV). There has been a significant decrease in the incidence and...

(This article belongs to the Special Issue Cellular and Molecular Biology of Cancer Stem Cells)
  • Article
  • Open Access
12 Citations
5,467 Views
29 Pages

Multilingual Framework for Risk Assessment and Symptom Tracking (MRAST)

  • Valentino Šafran,
  • Simon Lin,
  • Jama Nateqi,
  • Alistair G. Martin,
  • Urška Smrke,
  • Umut Ariöz,
  • Nejc Plohl,
  • Matej Rojc,
  • Dina Bēma and
  • Izidor Mlakar
  • + 2 authors

8 February 2024

The importance and value of real-world data in healthcare cannot be overstated because it offers a valuable source of insights into patient experiences. Traditional patient-reported experience and outcomes measures (PREMs/PROMs) often fall short in a...

(This article belongs to the Special Issue Biomedical Data and Imaging: Sensing, Understanding and Applications)
  • Review
  • Open Access
8 Citations
2,819 Views
26 Pages

Artificial Intelligence in Orthopaedics: Clinical Performance, Limitations, and Translational Readiness—A Review

  • Wojciech Michał Glinkowski,
  • Antonina Spalińska,
  • Agnieszka Wołk and
  • Krzysztof Wołk

25 February 2026

Background/Objectives: Musculoskeletal disorders and their surgical treatment significantly affect global disability, healthcare utilization, and costs. Artificial intelligence (AI) is a key enabler of data-driven musculoskeletal care. Their applicat...

(This article belongs to the Topic Machine Learning and Deep Learning in Medical Imaging)
  • Article
  • Open Access
4 Citations
1,949 Views
24 Pages

What to Measure? Development of a Core Outcome Set to Assess Remote Technologies for Cochlear Implant Users

  • Catherine Sucher,
  • David Allen,
  • Emma Laird,
  • Isabelle Boisvert and
  • Melanie Ferguson

30 October 2025

Background/Objectives: Uptake of remote cochlear implant (CI) services is feasible in clinical studies, but implementation into regular clinical practice is limited. Effective implementation requires demonstration of at least equivalent outcomes to i...

(This article belongs to the Special Issue The Challenges and Prospects in Cochlear Implantation)
  • Systematic Review
  • Open Access
2 Citations
716 Views
21 Pages

Neurophysiological and Structural–Mechanical Changes Associated with Dry Needling in Post-Stroke Spasticity: A Systematic Review

  • Bart Eeckhaut,
  • Steven Truijen,
  • Caroline Leroij,
  • Juliette Dévillé,
  • Lisa Jacobs and
  • Wim Saeys

30 May 2026

Background/Objectives: In the past few years increasing attention has been given to the application of dry needling (DN) for spasticity in stroke survivors. Nevertheless, the underlying mechanisms of this technique have not yet been confirmed. The ai...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
1 Citations
1,239 Views
11 Pages

Making Symptoms Visible: The Impact of Real-Time PROM Integration in Pediatric Oncology

  • Natalie Bradford,
  • Ethan Whalan,
  • Paula Condon,
  • Remziye Semerci,
  • Alison Bowers and
  • Xiomara Skrabal Ross

23 January 2026

Background/Objectives: Children undergoing cancer treatment experience multiple distressing symptoms that often go undetected in routine care. This study evaluated the potential impact of integrating the Symptom Screening in Pediatrics Tool (SSPedi)...

(This article belongs to the Section Global Pediatric Health)
  • Article
  • Open Access
6 Citations
4,118 Views
16 Pages

Intraoperative Load Sensing in Total Knee Arthroplasty Leads to a Functional but Not Clinical Difference: A Comparative, Gait Analysis Evaluation

  • Michele Giuntoli,
  • Michelangelo Scaglione,
  • Enrico Bonicoli,
  • Nicola Piolanti,
  • Gianmarco Puccioni,
  • Karlos Zepeda,
  • Emanuele Giannini,
  • Stefano Marchetti and
  • Pier Francesco Indelli

Introduction: Although Total Knee Arthroplasty (TKA) is a successful procedure, a significant number of patients are still unsatisfied, reporting instability at the mid-flexion range (Mid-Flexion Instability-MFI). To avoid this complication, many inn...

(This article belongs to the Special Issue Working Group in Sports Medicine)
  • Article
  • Open Access
397 Views
12 Pages

20 July 2026

Background and Objectives: The wrist is one of the most common sites of rheumatic disease. Based on the graded deformities of Larsen et al., surgery has been adapted to minimize harm while maximizing benefit to the individual. This study aims to surv...

(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Hand–Wrist Disorders)
  • Article
  • Open Access
3 Citations
2,210 Views
11 Pages

An Analysis of the Preoperative Factors, Spinopelvic Mobility and Sagittal Spinal Alignment in Pre-THA Patients

  • Mariusz Łaziński,
  • Włodzimierz Niemyjski,
  • Michał Niemyjski,
  • Marek Synder,
  • Marek Drobniewski,
  • Łukasz Olewnik and
  • Andrzej Borowski

27 August 2023

Hip arthroplasty is a very effective medical procedure. The optimal positioning of the components and the functioning of the endoprosthesis are influenced, among other things, by the mobility and balance of the spine. The aim of the study was to anal...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
514 Views
16 Pages

Background/Objectives: Chronic spontaneous urticaria (CSU) is a heterogeneous immune-mediated condition involving multiple inflammatory pathways. The clinical utility of platelet-activating factor (PAF) as a biomarker in CSU remains insufficiently de...

(This article belongs to the Section Immunology and Immunotherapy)
  • Article
  • Open Access
7 Citations
4,093 Views
11 Pages

6 March 2023

Background: Distal radius fractures (DRFs) in the elderly are common. Recently, the efficacy of operative treatment of displaced DRFs in patients above 65 years of age has been questioned and it has been suggested that non-operative treatment should...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
8 Citations
3,618 Views
23 Pages

A Description of the Yield of Genetic Reinvestigation in Patients with Inherited Retinal Dystrophies and Previous Inconclusive Genetic Testing

  • Maria Areblom,
  • Sten Kjellström,
  • Sten Andréasson,
  • Anders Öhberg,
  • Lotta Gränse and
  • Ulrika Kjellström

8 July 2023

In the present era of evolving gene-based therapies for inherited retinal dystrophies (IRDs), it has become increasingly important to verify the genotype in every case, to identify all subjects eligible for treatment. Moreover, combined insight conce...

(This article belongs to the Special Issue Genetics in Retinal Diseases)
  • Article
  • Open Access
345 Views
17 Pages

High Patient Satisfaction with a Digital Care Platform After Thoracolumbar Spine Surgery: A Registry-Based Analysis

  • Phil Bohlen,
  • Nicholas Dietzman,
  • Woo-Keun Kwon,
  • Jannik Leyendecker,
  • Paula Krause,
  • Jan Bredow,
  • Peer Eysel,
  • Albert Telfeian,
  • Peter Derman and
  • Christoph P. Hofstetter
  • + 13 authors

1 August 2026

Background/Objectives: SPINEHealthie is a smartphone-based application enabling remote patient monitoring, care delivery and standardized collection of patient-reported outcome measures (PROMs). This registry-based analysis evaluates patient satisfac...

  • Article
  • Open Access
878 Views
14 Pages

The Safety of Two Different Oral Misoprostol Dosing Strategies for Labor Preinduction at Term: A Single-Center Retrospective Cohort Study

  • Magdalena Adamczyk,
  • Witold Włodzimierz Kędzia,
  • Julia Rogalska,
  • Paulina Mularczyk and
  • Małgorzata Kędzia

22 March 2026

Background/Objectives: Preinduction of labor is commonly performed in women with unfavorable cervical conditions at term. Oral misoprostol is increasingly used due to its ease of administration and effectiveness; however, optimal dosing regimens rema...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
1 Citations
1,522 Views
17 Pages

Retrospective Cohort Study of 221 Cases of Epidural Per-Cutaneous Peri-Neural Release (Adhesiolysis)

  • Yasin Said Almakadma,
  • Jouhara Jouhar,
  • Abdulaziz Farooq and
  • Tahani Albatarni

Background: Lower limb (LL) and low back Radicular Syndromes (RSs) may result from discopathy of the lumbo-sacral spine. Consistent benefits are reported from Epidural Adhesiolysis (EA). Aim: To evaluate clinical and European Quality of Life items (E...

  • Article
  • Open Access
7 Citations
3,429 Views
17 Pages

Preservation of the Hypoxic Transcriptome in Glioblastoma Patient-Derived Cell Lines Maintained at Lowered Oxygen Tension

  • Agata Gozdz,
  • Bartosz Wojtaś,
  • Patrycja Szpak,
  • Paulina Szadkowska,
  • Tomasz Czernicki,
  • Andrzej Marchel,
  • Katarzyna Wójtowicz,
  • Wojciech Kaspera,
  • Piotr Ladzinski and
  • Ilona Kalaszczynska
  • + 4 authors

4 October 2022

Despite numerous efforts aiming to characterise glioblastoma pathology (GBM) and discover new therapeutic strategies, GBM remains one of the most challenging tumours to treat. Here we propose the optimisation of in vitro culturing of GBM patient-deri...

(This article belongs to the Special Issue Cancer Microenvironment–Hypoxia)
  • Systematic Review
  • Open Access
8 Citations
2,691 Views
16 Pages

Clinical Application of 3D-Assisted Surgery Techniques in Treatment of Intra-Articular Distal Radius Fractures: A Systematic Review in 718 Patients

  • Lisanne J. M. Roelofs,
  • Nick Assink,
  • Joep Kraeima,
  • Kaj ten Duis,
  • Job N. Doornberg,
  • Jean-Paul P. M. de Vries,
  • Anne M. L. Meesters and
  • Frank F. A. IJpma

30 November 2024

Objectives: Three-dimensional (3D) technology is increasingly applied in the surgical treatment of distal radial fractures and may optimize surgical planning, improve fracture reduction, facilitate implant and screw positioning, and thus prevent surg...

(This article belongs to the Section Orthopedics)

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