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Review

Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review

1
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta
2
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
3
BioDNA Laboratories, Malta Life Sciences Park, SGN 3000 San Gwann, Malta
4
Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, 7491 Trondheim, Norway
5
Department of Medicine and Surgery, LUM University “Giuseppe DeGennaro”, 70010 Casamassima, Italy
6
Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Célia Maria Freitas Gomes and Sara R. Martins-Neves
Int. J. Mol. Sci. 2022, 23(9), 5167; https://doi.org/10.3390/ijms23095167
Received: 6 April 2022 / Revised: 1 May 2022 / Accepted: 4 May 2022 / Published: 5 May 2022
(This article belongs to the Special Issue Cellular and Molecular Biology of Cancer Stem Cells)
Cervical cancer (CC) is the fourth most common type of gynecological malignancy affecting females worldwide. Most CC cases are linked to infection with high-risk human papillomaviruses (HPV). There has been a significant decrease in the incidence and death rate of CC due to effective cervical Pap smear screening and administration of vaccines. However, this is not equally available throughout different societies. The prognosis of patients with advanced or recurrent CC is particularly poor, with a one-year relative survival rate of a maximum of 20%. Increasing evidence suggests that cancer stem cells (CSCs) may play an important role in CC tumorigenesis, metastasis, relapse, and chemo/radio-resistance, thus representing potential targets for a better therapeutic outcome. CSCs are a small subpopulation of tumor cells with self-renewing ability, which can differentiate into heterogeneous tumor cell types, thus creating a progeny of cells constituting the bulk of tumors. Since cervical CSCs (CCSC) are difficult to identify, this has led to the search for different markers (e.g., ABCG2, ITGA6 (CD49f), PROM1 (CD133), KRT17 (CK17), MSI1, POU5F1 (OCT4), and SOX2). Promising therapeutic strategies targeting CSC-signaling pathways and the CSC niche are currently under development. Here, we provide an overview of CC and CCSCs, describing the phenotypes of CCSCs and the potential of targeting CCSCs in the management of CC. View Full-Text
Keywords: cervical cancer; cancer stem cells; drug resistance; radio-resistance; EMT; quiescence; epigenetic; targeted therapy; delivery systems cervical cancer; cancer stem cells; drug resistance; radio-resistance; EMT; quiescence; epigenetic; targeted therapy; delivery systems
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MDPI and ACS Style

Di Fiore, R.; Suleiman, S.; Drago-Ferrante, R.; Subbannayya, Y.; Pentimalli, F.; Giordano, A.; Calleja-Agius, J. Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review. Int. J. Mol. Sci. 2022, 23, 5167. https://doi.org/10.3390/ijms23095167

AMA Style

Di Fiore R, Suleiman S, Drago-Ferrante R, Subbannayya Y, Pentimalli F, Giordano A, Calleja-Agius J. Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review. International Journal of Molecular Sciences. 2022; 23(9):5167. https://doi.org/10.3390/ijms23095167

Chicago/Turabian Style

Di Fiore, Riccardo, Sherif Suleiman, Rosa Drago-Ferrante, Yashwanth Subbannayya, Francesca Pentimalli, Antonio Giordano, and Jean Calleja-Agius. 2022. "Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review" International Journal of Molecular Sciences 23, no. 9: 5167. https://doi.org/10.3390/ijms23095167

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