Special Issue "Kinase Inhibitors in Cancer and Central Nervous System"
A special issue of Scientia Pharmaceutica (ISSN 2218-0532).
Deadline for manuscript submissions: 28 March 2019
Prof. Dr. Thierry Besson
Normandie Univ, Univ Rouen; INSA Rouen, CNRS, Laboratoire COBRA UMR6014Bâtiment IRCOF, 1 rue Tesnière, F-76821 Mont Saint-Aignan Cedex, France
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Interests: N,O,S-heterocycles for therapeutic applications; microwave-assisted chemistry; active drugs for cancer and central nervous system; cancer and CNS drugs
Protein kinases catalyse protein phosphorylation—a key cellular regulatory mechanism which is frequently dysregulated in human diseases. Kinases have consequently been linked to the progress of a variety of diseases, including cancer and neurodegenerative disorders. Therefore, the search for therapeutic inhibitors of specific kinases has been developed in the last three decades as a major approach to discovering new therapeutic drugs. Initially focused on the discovery, optimization, and characterization of tyrosine kinase inhibitors and on cancer indications, the field is now rapidly expanding towards serine/threonine kinases and essentially all other therapeutic indications as neurodegenerative diseases (Alzheimer’s disease, Down syndrome).
In this Special Issue, our goal is to highlight papers describing an intended inhibition of specific kinases, although they are not always the initial and main target of the compounds tested. In silico molecular design connected with the development of chemical syntheses and pertinent comments on the forthcoming applications of these inhibitors will be particularly appreciated.
Prof. Dr. Thierry Besson
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Alzheimer’s disease
- neurodegenerative diseases
- Down syndrome
- kinase inhibitors
- in silico design
- multi-target drug ligand
- cancer cell quiescence
- chemical synthesis
- tyrosine kinases
- Ser/Thr kinases
- dual-specificity tyrosine phosphorylation-regulated kinases