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Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France
Nuclear Medicine Department, Montpellier Cancer Institute (ICM), University of Montpellier, 208 Avenue des Apothicaires, CEDEX 5, 34298 Montpellier, France
Department of Pharmacy, Lapeyronie Hospital, CHU Montpellier, 191 Av. du Doyen Gaston Giraud, 34295 Montpellier, France
Author to whom correspondence should be addressed.
Academic Editors: Thierry Besson and Pascal Marchand
Pharmaceuticals 2022, 15(1), 35;
Received: 13 December 2021 / Revised: 23 December 2021 / Accepted: 23 December 2021 / Published: 27 December 2021
(This article belongs to the Special Issue Heterocyclic Compounds and Their Application in Therapy)
Thienopyrimidines are widely represented in the literature, mainly due to their structural relationship with purine base such as adenine and guanine. This current review presents three isomers—thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and thieno[3,4-d]pyrimidines—and their anti-infective properties. Broad-spectrum thienopyrimidines with biological properties such as antibacterial, antifungal, antiparasitic and antiviral inspired us to analyze and compile their structure–activity relationship (SAR) and classify their synthetic pathways. This review explains the main access route to synthesize thienopyrimidines from thiophene derivatives or from pyrimidine analogs. In addition, SAR study and promising anti-infective activity of these scaffolds are summarized in figures and explanatory diagrams. Ligand–receptor interactions were modeled when the biological target was identified and the crystal structure was solved. View Full-Text
Keywords: thienopyrimidine; antibacterial; antifungal; antiparasitic; antiviral thienopyrimidine; antibacterial; antifungal; antiparasitic; antiviral
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MDPI and ACS Style

Lagardère, P.; Fersing, C.; Masurier, N.; Lisowski, V. Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents. Pharmaceuticals 2022, 15, 35.

AMA Style

Lagardère P, Fersing C, Masurier N, Lisowski V. Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents. Pharmaceuticals. 2022; 15(1):35.

Chicago/Turabian Style

Lagardère, Prisca, Cyril Fersing, Nicolas Masurier, and Vincent Lisowski. 2022. "Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents" Pharmaceuticals 15, no. 1: 35.

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