The 20th Anniversary of Pharmaceuticals—Heterocyclic Compounds and Their Application in Therapy
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 3395
Special Issue Editors
Interests: chemistry of heterocyclic compounds; microwave-assisted chemistry; sustainable methodologies; green chemistry applied to bioactive compounds: kinase inhibitors; Alzheimer's disease; down syndrome; cancer
Special Issues, Collections and Topics in MDPI journals
Interests: design, synthesis and biological evaluation of heterocyclic compounds for therapeutic purposes (mycology, parasitology, bacteriology and cancer); inhibitors of kinase signaling pathways; ADMET properties of molecules of biological interest
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heterocycles are present in numerous organic compounds of interest in biology, pharmacology, and medicine. Aromatic and non-aromatic molecules are still some of the largest areas of research in organic and medicinal chemistry. Efforts in exploring novel techniques or methods for synthesizing and functionalizing these compounds have increased, becoming some of the major axes of sustainable chemistry. Heterocycles exhibit unique structures, leading to several applications in the design of drugs. The presence of heteroatoms (e.g., N, S, and O) in the cyclic molecular structures results in significant physicochemical properties. Hydrogen bond donors and acceptors in these rigid frameworks allow hydrogen bond interactions with receptors and/or target enzymes, enhancing binding affinity and improving therapeutic potency. Heterocycles can also be involved in the design of prodrugs and modulate the lipophilicity of bioactive molecules, thus varying their pharmacokinetic and pharmaceutical properties. This Special Issue aims to review recent developments in the design, synthesis, and pharmaceutical properties of natural products as well as synthetic compounds containing aromatic heterocyclic systems.
Prof. Dr. Thierry Besson
Prof. Dr. Pascal Marchand
Guest Editors
Manuscript Submission Information
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Related Special Issue
- Heterocyclic Compounds and Their Application in Therapy in Pharmaceuticals (30 articles)
