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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Secondary Metabolites: Phytochemical Analysis and Bioactivity Assays—2nd Edition

edited by

Chiara Toniolo

and

Luca Santi

submission deadline 31 Mar 2026 | Viewed by 109 | Submission Open

Keywords: secondary metabolites; phytochemical analysis; biological activity; plant extracts; bioactive compounds; medicinal plants; food plants

(This special issue belongs to the Section Plant Metabolism)

Lipid Metabolism in Age-Related Diseases: 2nd Edition

edited by

Simona Fenizia

Elettra Barberis

and

Marcello Manfredi

submission deadline 31 Mar 2026 | Viewed by 109 | Submission Open

Keywords: lipid metabolism; metabolic diseases; high-throughput mass spectrometry-based lipidomics; aging; lipid biomarkers; precision medicine

(This special issue belongs to the Section Lipid Metabolism)

Glycolysis and the Kidney: Mechanistic Insights, Disease Trajectories and Therapeutic Horizons

edited by Pinelopi Kapitsinou

submission deadline 31 Mar 2026 | Viewed by 99 | Submission Open

Keywords: glycolysis; kidney physiology and pathology; mitochondrial metabolism; therapies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Metabolites and the Gut Microbiota in Development, Homeostasis, and Diseases

edited by Miriam Di Mattia and

Valentina Petito

submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open

Keywords: microbiota; metabolites; gut homeostasis; intestinal barrier; host interactions; inflammation; gut– organ axis

(This special issue belongs to the Section Cell Metabolism)

Biological Activity and Chemical Biodiversity of Plant Secondary Metabolites

edited by

Catherine Cook

submission deadline 31 Mar 2026 | Viewed by 80 | Submission Open

Keywords: secondary metabolites; chemical diversity; biological activities; plant defense; environmental interactions; nutritional and medicinal applications

(This special issue belongs to the Section Plant Metabolism)

Metabolic Dysfunction in Cardiac Adipose Tissue and Valvular Disease

edited by Pedro E. Antunes, Ana Burgeiro and Gonçalo Coutinho

submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open

Keywords: epicardial adipose tissue; valvular disease; coronary artery disease; metabolic syndrome; obesity; diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Lipidomics in MASLD and Related Liver Disorders

edited by Aleksandra Bołdys and Michał Nicze

submission deadline 1 Apr 2026 | 1 articles | Viewed by 560 | Submission Open

Keywords: MASLD; metabolomics; lipidomics; liver disease; biomarkers; metabolic profiling; nonalcoholic fatty liver disease; oxidative stress; mitochondrial dysfunction; systems biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 15 Apr 2026 | 2 articles | Viewed by 4145 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

edited by Miri Park and Jeehwan Choe

submission deadline 15 Apr 2026 | 1 articles | Viewed by 873 | Submission Open

Keywords: gut microbiota; diet and microbiome; probiotics; prebiotics; circadian rhythms; microbial metabolites; host– microbe interactions; nutritional strategies; gut– brain axis; metabolic health

(This special issue belongs to the Section Cell Metabolism)

Functional Foods and Natural Bioactive Compounds: Strategies to Face Metabolic Syndrome and Related Non-Communicable Diseases—2nd Edition

edited by

Paola Gauffin-Cano

, Sebastián Torres and

Roxana Medina

submission deadline 15 Apr 2026 | Viewed by 181 | Submission Open

Keywords: functional foods; bioactive compounds; fermented foods; fermented beverages; fermented vegetable foods; probiotics; prebiotics; synbiotics; postbiotics; metabolic syndrome; non-communicable diseases

Microbial Regulation of Host Metabolism

edited by

Kippeum Lee

submission deadline 15 Apr 2026 | Viewed by 102 | Submission Open

Keywords: gut microbiota-derived metabolites; short-chain fatty acids (SCFAs); gut hormones; bile acid; probi-otics; postbiotics; gut microbiota; microbiome; physiological function; metabolism balance

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Early-Stage Biomarkers: Metabolomics in Preclinical and Prodromal Disease Detection

edited by

Sonali Mishra

and Preeti Bais

submission deadline 15 Apr 2026 | Viewed by 62 | Submission Open

Keywords: early-stage biomarkers; metabolomics; biomarker validation; untargeted and targeted approaches; cohort studies; multi-omics integration; machine learning / AI; translational research; early disease detection; cancer; neurodegenerative; cerebrovascular; autoimmune; infectious; and psychiatric disorders

(This special issue belongs to the Section Advances in Metabolomics)

Effects of Micronutrients on Human Metabolism

edited by

Lin Xiao

submission deadline 17 Apr 2026 | 1 articles | Viewed by 1323 | Submission Open

Keywords: micronutrients; trace minerals; vitamins; human metabolism; metabolic processes; obesity; diabetes; cardiovascular disease

(This special issue belongs to the Section Food Metabolomics)

Effects of Secondary Plant Metabolites on Human Health

edited by

Beáta Čižmárová

and

Anna Birková

submission deadline 17 Apr 2026 | 1 articles | Viewed by 1160 | Submission Open

Keywords: human health; inflammation; cancer; obesity; antioxidants; phytochemicals; phytoestrogens; secondary metabolites; natural products

(This special issue belongs to the Section Plant Metabolism)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment, 2nd Edition

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 25 Apr 2026 | Viewed by 83 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional disorders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 30 Apr 2026 | 3 articles | Viewed by 6066 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

edited by

Sylwia Dzięgielewska-Gęsiak

Teresa Grzelak

and Grzegorz Dziubanek

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5961 | Submission Open

Keywords: nutritional attitudes and behaviors; bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota; dietary supplements; trace elements— Zn; Cu; heavy metals

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

edited by

Joshua De Leon

submission deadline 30 Apr 2026 | 4 articles | Viewed by 5867 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Neuronutrition: Metabolomic Insights and Perspectives

edited by

Abraham Wall Medrano

and Rocío Campos Vega

submission deadline 30 Apr 2026 | 1 articles | Viewed by 4696 | Submission Open

Keywords: neuronutrition; neurological disorders; nutrition; functional foods; nutraceutical; nutrition physiology; nutriomics

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Modulators in Cardiovascular Disease Management

edited by

Syed Siraj A. Quadri

submission deadline 30 Apr 2026 | 4 articles | Viewed by 4619 | Submission Open

Keywords: metabolic modulators; cardiovascular therapeutics; mitochondrial function; cardiometabolic disorders; energy metabolism; metabolic syndrome; therapeutic targets; heart failure; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3204 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Techniques in Nutrition and Pharmacy Research

edited by

Blake Rushing

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2595 | Submission Open

Keywords: metabolomics; precision nutrition; precision medicine; nutritional biomarkers; pharmacometabolomics; mass spectrometry; metabolic pathways; omics integration; diet– drug interactions; personalized therapeutics

(This special issue belongs to the Section Nutrition and Metabolism)

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1503 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1338 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Profiling in Neurometabolisms

edited by Larissa Daniele Bobermin

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1260 | Submission Open

Keywords: brain; energy homeostasis; glial cells; metabolic disorders; metabolic profiles; neurometabolism; neurons

The Role of Diet and Nutrition in Relation to Metabolic Health

edited by

Ivana Šarac

Marija Paunovic

and

Marija Takić

submission deadline 30 Apr 2026 | 1 articles | Viewed by 692 | Submission Open

Keywords: dietary patterns; nutrients; metabolic syndrome; diet; metabolic health; nutritional biochemistry; dietotherapy; functional food; nutraceuticals

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolism and Reproduction in Animals

edited by

Simona Tafuri

and

Francesca Ciani

submission deadline 30 Apr 2026 | Viewed by 284 | Submission Open

Keywords: metabolism; reproduction; welfare; nutraceuticals; oxidative stress; antioxidants; inflammation; cancer

(This special issue belongs to the Section Animal Metabolism)

New Technology and Workflows for Advancing Metabolomics

edited by Lee Andrew Gethings

submission deadline 30 Apr 2026 | Viewed by 280 | Submission Open

Keywords: mass spectrometry; NMR; discovery metabolomics; targeted metabolomics; lipidomics; mass spectrometry imaging; new technology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Salivary Biomarkers and Metabolites in Pigs

edited by

Fernando Tecles

submission deadline 30 Apr 2026 | Viewed by 187 | Submission Open

Keywords: saliva; biomarkers; welfare and health; animals

(This special issue belongs to the Section Animal Metabolism)

Metabolomics of the Eye and Adnexa—2nd Edition

edited by

Seher Yuksel

and

Igor Butovich

submission deadline 30 Apr 2026 | Viewed by 186 | Submission Open

Keywords: metabolomics; metabolites; ocular disease; meibomian gland dysfunction; age-related macular degeneration; glaucoma; diabetic retinopathy; keratoconus; gas chromatography/liquid chromatography– mass spectrometry; nuclear magnetic resonance spectroscopy

(This special issue belongs to the Section Advances in Metabolomics)

Nature’s Vanguard: Secondary Metabolites and Their Emerging Role in the Evolution of Cancer Therapy

edited by

Thiago André Moura Veiga

and

Edgar Julian Paredes-Gamero

submission deadline 30 Apr 2026 | Viewed by 171 | Submission Open

Keywords: natural compounds; cell signaling; cytotoxic effects; mechanism of action; molecular dereplication; plant; fungi; bacteria; marines; molecular docking

(This special issue belongs to the Section Plant Metabolism)

The Metabolic Genesis of Cardiovascular Disease

edited by

Davide Agnoletti

submission deadline 30 Apr 2026 | Viewed by 137 | Submission Open

Keywords: metabolic disorder; insulin resistance; inflammation; immune system; cardiovascular disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Translational Perspectives on Cancer Energy Metabolism: From Metabolic Mechanisms to Clinical Applications

edited by

Michael Weichhaus

and Helen Turner

submission deadline 30 Apr 2026 | Viewed by 97 | Submission Open

Keywords: cancer metabolism; Warburg effect; metabolic reprogramming; metabolic flux analysis; biomarkers; targeted therapies; clinical translation; population metabolomics; health disparities

(This special issue belongs to the Section Cell Metabolism)

The Aging Blueprint: Decoding Biomarkers of Bone and Muscle Health

edited by

Sagar Vyavahare

submission deadline 30 Apr 2026 | Viewed by 79 | Submission Open

Keywords: metabolomics; bone; muscle; aging; biomarker

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Research in Animal Nutrition and Production 2nd Edition

edited by Tietao Zhang and Qingkui Jiang

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: special economic animals; companion animals; nutrition; metabolomics; microbiome; metabolites; animal nutrition; animal production; animal health and disease; metabolic phenotypes

(This special issue belongs to the Section Animal Metabolism)

Harnessing Cancer Metabolism: Unveiling New Therapeutic Approaches and Diagnostic Tools

edited by

Victor H. Villar

, Alejandro Huerta-Uribe and Ruhi Deshmukh

submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open

Keywords: cancer; metabolic pathways; apoptosis; treatment

(This special issue belongs to the Section Cell Metabolism)

Diversity of Fungal Secondary Metabolites and Bioactive Compound Discovery

edited by

Fenglin Hu

submission deadline 30 Apr 2026 | Viewed by 71 | Submission Open

Keywords: fungi; secondary metabolites; biosynthesis; analysis; bioactivity; identification; metabolism; utilization

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolic Research in Dairy Cattle Health

edited by

Wei Yang

submission deadline 30 Apr 2026 | Viewed by 68 | Submission Open

Keywords: dairy cow; nutrient metabolism; feed ingredients; additives; disease; microbes; metabolite biomarkers

(This special issue belongs to the Section Animal Metabolism)

Metabolic Signature of Type 2 Diabetes, Insulin Resistance, and Obesity Triad

edited by Simona Georgiana Popa

submission deadline 30 Apr 2026 | Viewed by 68 | Submission Open

Keywords: cardiometabolic phenotypes of obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of VOCs in Communication Between Plants and Microorganisms on Metabolomics

edited by

Valentina Lazazzara

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: volatile organic compounds (VOCs); plant-microbe interaction; sustainable agriculture; plant signaling; plant– pathogen interactions; plant growth promotion; microbial volatiles; plant defense mechanisms; biocontrol

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Computational Modeling of Metabolite-Modulated Cellular Processes

edited by

Md. Altaf-Ul-Amin

and Naoaki Ono

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: computational metabolomics; metabolic networks; metabolite-regulated cellular processes; natural products; drug discovery; metabolite biomarkers; machine learning algorithms

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Bile Acid Transport and Metabolic Disorders

edited by

Subha Arthur

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: bile acid transporters; FXR (Farnesoid X Receptor); TGR5; enterohepatic circulation; metabolic regulation; NAFLD (non-alcoholic fatty liver disease); gut microbiota; insulin resistance; bile acids and cardiovascular diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Drug Metabolism and New Drug Development for Cancers—2nd Edition

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

The Impact of Toxic Metals on Human Metabolism and Health

edited by

Lucyna Kozlowska

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: metabolomics; exposomics; suspect screening; non-targeted screening; metals; health effect; metabolic profile

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic and Neurodegenerative Disease Comorbidities

edited by

Aleksandra Szopa

and

Anna Serefko

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: metabolic disorders; neurodegeneration; diabetes; Alzheimer’ s disease; Parkinson’ s disease; mito-chondrial dysfunction; oxidative stress; neuroinflammation; gut– brain axis; metabolic comorbidities

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Multi-Omics for Identifying Biosynthetic Pathways of Active Components in Medicinal Plants

edited by

Lihang Xie

and

Wolfgang Eisenreich

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: multi-omics; medicinal plants; bioactive natural products; biosynthetic pathway; metabolic engineering; microbial cell factories

(This special issue belongs to the Section Plant Metabolism)

Changes in Body Composition (Bone, Muscle, Adipose Tissue) with Age and Accompanying Biomarkers for Each Tissue

edited by

Jasminka Ilich

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: bone; muscle; adipose tissue; osteosarcopenic adiposity; nutrition; physical activity; and lifestyle habits influencing body composition; inflammatory markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathophysiology to Prevention Strategies

edited by

Seong-Uk Baek

and

Caroline Rhéaume

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: steatotic liver disease; epidemiology; MASLD; MAFLD; non-alcoholic fatty liver disease (NAFLD); liver metabolism; liver diseases; hepatic steatosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Molecular Mechanisms of Metabolic Pathway Regulation by Phytochemicals

edited by

Carlos Lopez-Ortiz

submission deadline 4 May 2026 | Viewed by 133 | Submission Open

Keywords: phytochemicals; plant metabolism; secondary metabolites; gene expression regulation; metabolomics

(This special issue belongs to the Section Plant Metabolism)

Advances in NMR- and MS-Based Metabolomics and Its Applications

edited by