Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathophysiology to Prevention Strategies
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 246
Special Issue Editors
2. Jangheung County Public Health Center, Jangheung-gun 59327, Republic of Korea
Interests: epidemiology; preventive medicine; public health
Interests: metabolic syndrome; lifestyle medicine; physical activity; nutrition; pri-mary care
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a major and growing public health concern, ranking among the most common liver diseases globally. Previously termed non-alcoholic fatty liver disease (NAFLD), the condition has been redefined to emphasize its close association with metabolic dysfunction, moving away from terminology focused on alcohol use. MASLD is currently regarded as a major metabolic disorder that negatively impacts the health of the global population. Research efforts are actively working to elucidate the biological mechanisms, metabolic biomarkers and metabolic pathways that underlie its pathophysiology.
In recent years, this emerging concept of MASLD has attracted significant attention from both public health experts and clinicians. MASLD is projected to cause a substantial health and economic burden in the coming decades. Therefore, understanding the epidemiology of MASLD is essential for determining its prevalence and distribution and for identifying at-risk populations. Recent epidemiological studies indicate that various cardiometabolic risk factors and complex socioeconomic determinants interplay in the pathogenesis of MASLD. However, we do not yet fully understand how the diverse range of risk factors—from genetic predispositions and lifestyle choices to socioeconomic positions and environmental exposures—collectively influence the onset and prognosis of MASLD. Research in this area is expected to provide novel insights into the etiology of MASLD, which can inform the development of effective preventive policies and clinical interventions.
The goal of this Special Issue is to showcase a collection of high-quality studies on the broad topic of MASLD, spanning its biological pathways, diagnosis and prevention. We welcome submissions of novel research conducted across diverse populations and geographic regions that address these critical knowledge gaps.
Dr. Seong-Uk Baek
Dr. Caroline Rhéaume
Guest Editors
Manuscript Submission Information
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Keywords
- steatotic liver disease
- epidemiology
- MASLD
- MAFLD
- non-alcoholic fatty liver disease (NAFLD)
- liver metabolism
- liver diseases
- hepatic steatosis
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