Diversity of Fungal Secondary Metabolites and Bioactive Compound Discovery

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 876

Special Issue Editor


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Guest Editor
Engineering Research Center of Fungal Biotechnology, Ministry of Education, Anhui Provincial Key Laboratory for Microbial Control, Anhui Agricultural University, Hefei 230036, China
Interests: analysis and identification of fungal bioactive metabolites
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Special Issue Information

Dear Colleagues,

Fungi represent a significant treasure house of bioactive compound resources. It is estimated that there are more than one million fungal species in the world, which is much greater than that of plant species. Compared with plants, fungi have greater diversity of secondary metabolites because of their varied living environments. Fungi can not only synthetize well-known antibiotics, such as penicillin and cephaloridine, but also growth regulators, immunoregulators, and antioxidants through which fungi can crosstalk with the environment. However, the secondary metabolites of more than 90% of fungi have not been studied, contributing to a lack of understanding of fungal language and utilization of fungal secondary metabolites. Therefore, this Special Issue aims to provide a platform to promote research on the diversity of fungal secondary metabolites and the discovery of bioactive compounds from fungi.

Prof. Dr. Fenglin Hu
Guest Editor

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Keywords

  • fungi
  • secondary metabolites
  • biosynthesis
  • analysis
  • bioactivity
  • identification
  • metabolism
  • utilization

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Published Papers (1 paper)

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Research

20 pages, 1821 KB  
Article
Bioactive Potential of the Wild Edible Fungus Rhizopogon roseolus (Corda) Th. Fr.
by Elif Yürümez Canpolat
Metabolites 2026, 16(3), 176; https://doi.org/10.3390/metabo16030176 - 6 Mar 2026
Viewed by 601
Abstract
Backgrouınd/Objectives: Edible fungi are increasingly regarded as important natural reservoirs of secondary metabolites exhibiting a wide range of biological activities. The present study aimed to molecularly identify Rhizopogon roseolus collected from Türkiye and to systematically evaluate its bioactive properties. Methods: The antimicrobial and [...] Read more.
Backgrouınd/Objectives: Edible fungi are increasingly regarded as important natural reservoirs of secondary metabolites exhibiting a wide range of biological activities. The present study aimed to molecularly identify Rhizopogon roseolus collected from Türkiye and to systematically evaluate its bioactive properties. Methods: The antimicrobial and antioxidant activities of methanolic, ethanolic, and aqueous extracts were evaluated. The phenolic profile and the fatty acid composition of the species were characterized using HPLC-DAD and GC–MS respectively. Results: All extracts showed noticeable antimicrobial activity against several pathogenic microorganisms, including Bacillus subtilis, Micrococcus luteus, Bacillus cereus and Pseudomonas aeruginosa. In addition, the extracts displayed remarkable antioxidant potential. The methanolic extract of R. roseolus demonstrated DPPH and ABTS radical scavenging activities of 651.44 ± 15.02 mg TE/g and 162.71 ± 8.11 mg TE/g, respectively. Its ferric reducing antioxidant power was determined as 724.33 ± 12.23 mg AAE/g DW, while the cupric reducing antioxidant capacity reached 952.45 ± 4.35 mg TE/g DW. These strong antioxidant effects were closely associated with the high phenolic content (9.89 ± 0.08 mg GAE/g DW) of the extracts. GC–MS analysis indicated that palmitoleic, oleic, and linoleic acids were the major fatty acids, while HPLC-DAD revealed that gallic acid and pyrocatechol were major phenolic compounds present in R. roseolus, suggesting a nutritionally beneficial metabolite composition. Conclusions: Taken together, the findings demonstrate that R. roseolus represents a promising natural source of antimicrobial and antioxidant compounds with potential applications. Full article
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