Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 16 September 2025 | Viewed by 1232

Special Issue Editor


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Guest Editor
Cambridge Liver Unit, Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Interests: endoscopic intervention; endoscopic ultrasound; lumen apposing metal stent; radiofrequency ablation; endoscopic sleeve gastroplasty; cholangioscopy; endoscopic retrograde cholangiopancreatography; liver disease; biliary disease; pancreatobiliary disease

Special Issue Information

Dear Colleagues,

Recently, much progress has been made in the endoscopic management of hepatic, pancreatic, and biliary (HPB) diseases. Endohepatology, or interventional hepatology, is an evolving subspecialty; hepatic venous portal pressure gradient measurements are increasingly being used, and early data suggest that endoscopic sleeve gastrectomy may improve metabolic dysfunction-associated fatty liver disease. Lumen-apposing metal stents have also grown in popularity in the treatment of pancreatic and biliary disorders. In this Special Issue, we invite original research articles, review articles or others showcasing the basic or clinical sciences associated with endoscopy in HPB disorders.

Dr. John Ong
Guest Editor

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Keywords

  • endoscopic intervention
  • endoscopic ultrasound
  • lumen apposing metal stent
  • radiofrequency ablation
  • endoscopic sleeve gastroplasty
  • cholangioscopy
  • endoscopic retrograde cholangiopancreatography
  • liver disease
  • biliary disease
  • pancreatobiliary disease

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Published Papers (1 paper)

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Research

10 pages, 224 KiB  
Article
Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography
by Giacomo Mulinacci, Clara Benedetta Conti, Alberto Savino, Davide Gandola, Davide Ippolito, Roberto Frego, Alessandro Ettore Redaelli, Marta Maino and Marco Emilio Dinelli
Life 2025, 15(1), 21; https://doi.org/10.3390/life15010021 - 28 Dec 2024
Viewed by 674
Abstract
Background and aims: Despite technical advances, endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications and potentially lethal outcomes. Sarcopenia, a complex syndrome mainly associated with aging, has been recognized as a predictor of poor surgical outcomes. Thus far, the impact of sarcopenia on [...] Read more.
Background and aims: Despite technical advances, endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications and potentially lethal outcomes. Sarcopenia, a complex syndrome mainly associated with aging, has been recognized as a predictor of poor surgical outcomes. Thus far, the impact of sarcopenia on ERCP remains unknown. The present study evaluates the role of sarcopenia as a predictor of ERCP-related outcomes in a cohort of elderly patients. Methods: Patients who underwent ERCP between June 2019 and January 2023 were retrospectively included. Demographic and procedure-associated data were collected. Sarcopenia was assessed using the skeletal muscle index (SMI) measured from a single axial slice through the L3 vertebra on a CT scan. ERCP-related outcomes were recorded. Univariate and multivariate analyses were used to assess the correlation between sarcopenia and procedural outcomes. Results: In total, 256 patients were enrolled, of whom 30 (11.7%) were sarcopenic. Cardiopulmonary complications of ERCP occurred in 3.5%. Sarcopenia was associated with higher 30-day and 12-month post-ERCP mortality (OR 3.45, p = 0.03; OR 3.87, p = 0.004) and longer hospitalization time (7 vs. 11 days, p = 0.003). Conclusions: SMI is an easy and objective index of sarcopenia that could be used to predict ERCP outcomes. Indeed, sarcopenia was independently associated with prolonged hospitalization and increased mortality in a retrospective cohort of elderly patients. Full article
(This article belongs to the Special Issue Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases)
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