Gynecological Endocrinology: From Physiological Mechanisms to Clinical Practice
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 29 August 2025 | Viewed by 1973
Special Issue Editor
Interests: reproductive endocrinology; metabolic syndrome; rare endocrine diseases
Special Issue Information
Dear Colleagues,
Gonadal endocrine diseases in women encompass a broad spectrum of common and rare conditions associated with ovarian dysfunction, sex hormonal disbalance, and infertility. Polycystic ovarian syndrome (PCOS) affects many young women, and its clinical manifestations not only include different signs of hyperandrogenism and menstrual disturbances but also an increased risk of metabolic complications. Even though congenital adrenal hyperplasia and androgen-producing tumors are rarely found, they should be considered in the differential diagnosis of hyperandrogenic PCOS. Despite apparent clinical symptoms, the genetic basis and epigenetic modifications leading to PCOS are far from clear. Further studies are therefore needed to enlighten the etiology and pathophysiology of this heterogeneous condition—particularly, those leading to new therapeutic opportunities for patients.
Beyond hyperandrogenic states, ovarian dysfunction might also result from disturbances in the hypothalamic–pituitary axis caused by a variety of factors. Continuous stress, eating disorders, as well as intensive physical activity might suppress the hypothalamic neurons regulating the pituitary, thus leading to hypothalamic amenorrhea. On the other hand, rare genetic mutations might cause an isolated hypogonadotropic hypogonadism in some female patients, which can be easily overlooked, especially in women undergoing long-term hormonal treatment.
Premature ovarian failure (POF) can not only be a devastating diagnosis for women with infertility but it could also have profound adverse effects on cardiovascular and bone health. Therefore, more effort should be invested into the development of new diagnostic tools for the early evaluation of ovarian follicular reserve and appropriate treatment.
Accordingly, this Special Issue focuses on the pathophysiology, clinical characteristics, biomarkers, and possible treatment of different ovarian disorders associated with endocrine disturbances. The topic includes (but is not limited to) PCOS, hypothalamic amenorrhea, congenital adrenal hyperplasia, hypogonadotropic hypogonadism, and premature ovarian insufficiency (POI). Extending knowledge in gynecological endocrinology is essential for improving women’s health; therefore, every valuable paper on the topic is welcomed.
Dr. Ralitsa Robeva
Guest Editor
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Keywords
- PCOS
- hypothalamic amenorrhea
- congenital adrenal hyperplasia
- hypogonadotropic hypogonadism
- premature ovarian insufficiency (POI)
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