Precision Medicine in Cardiovascular Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Genetics and Genomics".

Deadline for manuscript submissions: 29 August 2025 | Viewed by 2014

Special Issue Editor


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Guest Editor
Department of Cardiology, Jersey General Hospital, Gloucester Street, St. Helier JE1 3QS, UK
Interests: cardiology; stem cell therapy; electrophysiology; congenital heart disease

Special Issue Information

Dear Colleagues,

This Special Issue aims to explore the cutting-edge advancements in and applications of precision medicine in the realm of cardiovascular health. With a focus on tailoring treatment strategies to individual patients based on their genetic makeup, lifestyle factors, and environmental influences, this issue seeks to highlight the transformative potential of precision medicine in optimizing patient outcomes and revolutionizing cardiovascular care.

Through the collection of research articles, reviews, and case studies, this Special Issue will delve into various aspects of precision medicine, including molecular profiling, biomarker identification, personalized risk assessment, and targeted therapies for cardiovascular diseases. By elucidating the underlying mechanisms of cardiovascular conditions at the molecular level and identifying patient-specific factors that contribute to disease susceptibility and progression, this issue aims to pave the way for more precise diagnostic methods and therapeutic interventions.

Authors are encouraged to submit original research contributions, comprehensive reviews, and innovative perspectives that shed light on the role of precision medicine in reshaping the landscape of cardiovascular healthcare. By fostering interdisciplinary collaboration and sharing groundbreaking discoveries, this Special Issue endeavors to accelerate the translation of precision medicine concepts into clinical practice, ultimately improving patient outcomes and advancing the field of cardiovascular medicine.

Dr. Brian Xiangzhi Wang
Guest Editor

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Keywords

  • genomic
  • cardiovascular disease
  • congenital
  • multi-omics studies
  • precision medicine
  • personalized medicine
  • biomarker

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Published Papers (1 paper)

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Review

19 pages, 314 KiB  
Review
Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cell-Based Models
by Brian Xiangzhi Wang
Life 2024, 14(11), 1370; https://doi.org/10.3390/life14111370 - 25 Oct 2024
Viewed by 1630
Abstract
Inherited heart diseases (IHDs) are caused by genetic mutations that disrupt the physiological structure and function of the heart. Understanding the mechanisms behind these diseases is crucial for developing personalised interventions in cardiovascular medicine. Development of induced pluripotent stem cells, which can then [...] Read more.
Inherited heart diseases (IHDs) are caused by genetic mutations that disrupt the physiological structure and function of the heart. Understanding the mechanisms behind these diseases is crucial for developing personalised interventions in cardiovascular medicine. Development of induced pluripotent stem cells, which can then be differentiated to any nucleated adult cell type, has enabled the creation of personalised single-cell and multicellular models, providing unprecedented insights into the pathophysiology of IHDs. This review provides a comprehensive overview of recent advancements in human iPSC models used to dissect the molecular and genetic underpinnings of common IHDs. We examine multicellular models and tissue engineering approaches, such as cardiac organoids, engineered heart tissue, and multicellular co-culture systems, which simulate complex intercellular interactions within heart tissue. Recent advancements in stem cell models offer a more physiologically relevant platform to study disease mechanisms, enabling researchers to observe cellular interactions, study disease progression, and identify therapeutic strategies. By leveraging these innovative models, we can gain deeper insights into the molecular and cellular mechanisms underlying IHDs, ultimately paving the way for more effective diagnostic and therapeutic strategies. Full article
(This article belongs to the Special Issue Precision Medicine in Cardiovascular Diseases)
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