Channel Proteins and Transporters in Human Health and Disease
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Proteins and Proteomics".
Deadline for manuscript submissions: 29 August 2025 | Viewed by 875
Special Issue Editors
Interests: cell physiology; ion channel; transporters; calcium; signal transduction; endothelial cells; cell migration; angiogenesis; ion imaging; cell biology
Interests: physiology; calcium signaling; cell migration; cell adhesion; endothelial cells; angiogenesis; ion channels; cancer cells; signal transduction; cellular crosstalk
Interests: cell physiology; electrophysiology, ion channels and channelopathies; signal transduction pathways; cardiac cell physiology; cardiomyopathy; stem cells and regenerative medicine; optogenetic modulation
Special Issue Information
Dear Colleagues,
Channel proteins and transporters; which mediate the flow of ions; water; and biomolecules across cell membranes; represent the main molecular machinery responsible for cellular functional adaptation in response to environmental stimuli. Indeed; they regulate membrane potential and cell excitability; intercellular communication and intracellular signal transduction; systemic and cellular pH; and salt and water homeostasis. Their functional expression is crucial for the proper functioning of cells; tissues; and organs; and they play a central role in cellular physiology; neuroscience; and cardiovascular research. In addition to their primary function; they have been linked to the onset of neurological/neurodegenerative disorders; cardiovascular diseases; and cancer. For instance; their dysregulation affects cell cycle dynamics; apoptosis; cell migration; vascularization; with potential dramatic consequences for cell and organ physiology and; ultimately; human health. As a result; they have gained increased attention as molecular biomarkers and promising pharmaceutical targets.
This special issue aims to illustrate new and promising findings; stimulating future research on these important proteins. Original manuscripts and reviews exploring different roles of channel proteins/transporters in various aspects of human health and disease; are welcome (e.g., new approaches to study their expression; structure; and function or current insights into molecular mechanisms of pathological dysregulation that open new avenues for therapy and drug design).
Dr. Giorgia Scarpellino
Dr. Giorgia Chinigò
Dr. Roberta De Zio
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- channel proteins
- transporters
- ion channel
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