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Life
Special Issues
New Insights into Pediatric Rheumatic and Autoimmune Diseases
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New Insights into Pediatric Rheumatic and Autoimmune Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 204

Special Issue Editor

Dr. Lampros Fotis

E-Mail Website
Guest Editor
Department of Pediatrics, National and Kapodistrian University of Athens, "ATTIKON" General Hospital, Athens, Greece
Interests: pediatric rheumatology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue on New Insights into Pediatric Rheumatic and Autoimmune Diseases seeks to highlight emerging research and clinical advancements in the understanding, diagnosis, and management of rheumatic and autoimmune conditions in children. These disorders include juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, systemic connective tissue disorders, vasculitis, and autoinflammatory diseases. They present unique challenges due to their complex pathophysiology, variability in clinical presentation, and significant impact on the growth, development, and quality of life.

This Special Issue aims to bring together innovative research that explores new biomarkers for diagnosis and prognosis, advances in immunomodulatory and biologic therapies, and the role of genetic and environmental risk factors in disease pathogenesis. Topics of interest also include novel imaging techniques, patient-reported outcomes, long-term treatment safety, and interdisciplinary care strategies.

Additionally, this Special Issue emphasizes the integration of translational research into clinical practice, providing insights into how basic science discoveries can improve patient outcomes. By fostering an exchange of knowledge among clinicians, researchers, and allied healthcare professionals, this Special Issue aspires to expand the understanding of pediatric rheumatic and autoimmune diseases and contribute to the development of personalized and precision medicine approaches for young patients.

We welcome submissions of original research articles and comprehensive reviews that reflect the current state of knowledge and provide a foundation for future advancements in this critical area of pediatric medicine.

Dr. Lampros Fotis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arthritis
  • juvenile
  • autoimmune diseases
  • biomarkers
  • diagnostic imaging
  • juvenile dermatomyositis
  • lupus erythematosus
  • systemic
  • pediatric rheumatology
  • vasculitis

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Published Papers (1 paper)

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Review

20 pages, 653 KiB  
Review
Immunophenotype of Kawasaki Disease: Insights into Pathogenesis and Treatment Response
by Aikaterini Agrafiotou, Evdoxia Sapountzi, Angeliki Margoni and Lampros Fotis
Life 2025, 15(7), 1012; https://doi.org/10.3390/life15071012 - 25 Jun 2025
Viewed by 30
Abstract
Kawasaki disease (KD) is a systematic inflammatory condition that results in vasculitis and possible progression to the development of coronary artery lesions if left untreated. Disease pathogenesis is not fully understood, and diagnosis is based on clinical symptoms, with limited reliability considering that [...] Read more.
Kawasaki disease (KD) is a systematic inflammatory condition that results in vasculitis and possible progression to the development of coronary artery lesions if left untreated. Disease pathogenesis is not fully understood, and diagnosis is based on clinical symptoms, with limited reliability considering that KD progression is time sensitive. This is further complicated by the shared clinical characteristics with other febrile diseases. Early diagnosis and prompt treatment start are associated with good prognosis in most patients. However, up to 20% of patients are resistant to available therapeutic agents and would benefit from alternative regimens. Therefore, identification of biomarkers that can provide insights on disease pathogenesis are necessary to enable early diagnosis and initiation of treatment, as well as to predict treatment responses. To this end, immunophenotyping, most commonly by flow cytometry, has been crucial in identifying central factors in KD pathogenesis. The available literature on such factors is vast and may include contradictory findings. Therefore, we aimed to summarize the available literature of the last decade on the immunophenotype of KD, focusing on biomarkers associated with disease pathogenesis and those associated with treatment response. Our review highlights the role of cells of both the innate and adaptive immune system in disease pathogenesis, as well as the role of various secreted and cell surface proteins, including inflammatory cytokines, chemokines, complement receptors, and chemoattractants both in KD pathogenesis and in treatment response. Full article
(This article belongs to the Special Issue New Insights into Pediatric Rheumatic and Autoimmune Diseases)
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