Innovative Drug Development: Balancing Efficacy and Toxicity in Novel Pharmaceuticals
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 94
Special Issue Editor
2. Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, ”Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
Interests: bioactive natural compounds; drug derivatives; cancer research; targeted drug delivery; (nano)pharmaceuticals; in vitro toxicology
Special Issue Information
Dear Colleagues,
Drug development remains a complex and ongoing process leading to innovative medicines that address unmet medical needs. Despite recent advances, significant challenges such as limited efficiency, drug resistance, a lack of targeted action, or severe adverse reactions persist, hastening research on optimized therapeutics with a favorable risk–benefit profile. To overcome these obstacles and balance efficacy against toxicity, several strategies have emerged. These include the discovery of new pharmacologically active agents that target specific disease pathways, providing enhanced therapeutic properties and reduced toxic events, as well as the formulation of advanced drug delivery systems that enable the targeted transfer of the delivered agents, increasing their biological activity while minimizing side effects. This Special Issue invites innovative contributions to the development of novel pharmaceuticals with diverse applications through the obtainment, characterization, and rigorous pharmaco-toxicological screening of new active compounds of varied origins (e.g., natural, semisynthetic, or synthetic), as well as modern formulations designed for the targeted delivery of bioactive compounds. Studies that provide an integrated approach, combining both the rational design of novel pharmaceuticals and the mechanistic understanding of their biological activities, are strongly encouraged for submission to this Special Issue.
Dr. Iasmina Marcovici
Guest Editor
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Keywords
- drug development
- pharmaceuticals
- bioactive compounds
- new drug candidates
- drug delivery systems
- pharmaceutical formulations
- efficacy and toxicity screening
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