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Clinical Trends and Prospects in Urology Surgery: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: closed (20 May 2026) | Viewed by 746

Special Issue Editor


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Guest Editor
2nd Department of Urology, National and Kapodistrian University of Athens, Sismanogleion Hospital, 11526 Athens, Greece
Interests: urolithiasis; robotic surgery; prostate cancer; kidney cancer; bladder cancer
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Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue titled “Clinical Trends and Prospects in Urology Surgery: 2nd Edition”. This is a new volume, following the first volume with 5 published papers. For more details, please visit:
https://www.mdpi.com/journal/jcm/special_issues/592FZF6LC4

The field of urological surgery is rapidly changing due to fast technological advances in the field. Robotic surgery has already remained in the game for at least 20 years, but over the last two years, many new robotic platforms have appeared for oncologic and benign surgeries, such as for treating stones. In addition, the miniaturization of scopes, the introduction of suction technology, and improved lithotripsy devices and settings have revolutionized minimally invasive surgery for stones and urothelial tumors. Artificial intelligence seems to be a game-changer as well, with a growing number of platforms integrating AI-based algorithms to analyze data and provide navigation and assistance to the clinician/surgeon for improved outcomes. For these reasons, we believe that this Special Issue presents a great opportunity to incorporate all of these technological advances within urological surgery.

Dr. Lazaros Tzelves
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • robotic surgery
  • laparoscopic surgery
  • endourology
  • minimally invasive surgery
  • artificial intelligence

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Related Special Issue

Published Papers (1 paper)

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Research

12 pages, 694 KB  
Article
Trends in Treatment and Perioperative Outcomes of Upper Tract Urothelial Carcinoma: The Evolving Role of Lymphadenectomy and Neoadjuvant Chemotherapy
by Robert Bischoff, Nikolaos Pyrgidis, Benedikt Ebner, Yannic Volz, Julian Hermans, Marie Semmler, Patrick Keller, Gerald B. Schulz, Julian Marcon, Philipp Weinhold, Christian G. Stief and Lennert Eismann
J. Clin. Med. 2026, 15(7), 2536; https://doi.org/10.3390/jcm15072536 - 26 Mar 2026
Viewed by 420
Abstract
Objectives: Real-world data on surgical and multimodal management of upper tract urothelial carcinoma (UTUC) are limited. This study examined epidemiological trends, nephron-sparing surgery adoption, and the perioperative impact of lymphadenectomy (LND) and neoadjuvant chemotherapy (NAC). Methods: The German Nationwide Inpatient Data (GRAND) registry [...] Read more.
Objectives: Real-world data on surgical and multimodal management of upper tract urothelial carcinoma (UTUC) are limited. This study examined epidemiological trends, nephron-sparing surgery adoption, and the perioperative impact of lymphadenectomy (LND) and neoadjuvant chemotherapy (NAC). Methods: The German Nationwide Inpatient Data (GRAND) registry (2005–2023) identified UTUC patients undergoing radical nephroureterectomy (RNU), endoscopic laser destruction, or segmental ureteral resection (SUR) using OPS codes. Demographics, comorbidities, complications, and in-hospital mortality were extracted from ICD-10-GM data. Multivariable regression adjusted for baseline comorbidities assessed associations between treatment type, LND, NAC, and perioperative outcomes. Results: Among 53,427 UTUC patients, 77.3% underwent RNU, 13.8% endoscopic laser destruction, and 8.9% SUR. Endoscopic laser use rose from <10% (2005) to about 20% (2023). LND was performed in 13% of RNU cases, increasing from 1.1% to 19%. LND was associated with higher risks of transfusion (OR 1.47, 95% CI 1.37–1.57), acute kidney injury (OR 1.19, 95% CI 1.07–1.32), and ICU admission (OR 1.21, 95% CI 1.13–1.30), without affecting in-hospital mortality. NAC was given to 1.7% of patients, with a five-fold increase over time, and was associated with more transfusions (OR 1.28, 95% CI 1.07–1.52) and urinomas (OR 2.31, 95% CI 1.31–3.78), but not mortality. Conclusions: UTUC management is evolving, with growing use of endoscopic laser therapy and guideline-aligned lymphadenectomy during nephroureterectomy. Neoadjuvant chemotherapy remains underused despite acceptable perioperative safety, highlighting the need for increased awareness to optimize multimodal treatment. Full article
(This article belongs to the Special Issue Clinical Trends and Prospects in Urology Surgery: 2nd Edition)
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