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Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome
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Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 639

Special Issue Editors

Prof. Dr. Graziano Montaruli

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, Dental School of Foggia, University of Foggia, Foggia, Italy
Interests: orthodontics; obstructive sleep apnea syndrom; osseointegration; implant dentistry; periodontology; oral surgery
Prof. Dr. Domenico Ciavarella

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, FG, Italy
Interests: obstructive sleep apnea; temporomandibular joint disease; orthodontics; craniofacial morphology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Michele Tepedino

E-Mail Website
Guest Editor
Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: osas; impacted canines; craniofacial growth; development; gnathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I hope this mail finds you well.

We are pleased to invite esteemed experts to contribute papers to our Special Issue. As a valued researcher, we would be honored to have you as a contributor.

This Special Issue will feature papers on the Journal of Clinical Medicine that aims to present up-to-date and pertinent findings concerning diagnosis, therapy and management of Obstructive Sleep Apnea Syndrome, with particular focus to the multidisciplinary aspects of this widespread pathology.

The prevalence of OSA is approximately 22% in men and 17% in women, it represents a condition with important social implications because of sleep deprivation and daytime sleepiness.

Obstructive Sleep Apnea Syndrome is becoming an increasingly studied disease because of its many comorbidities and consequences, although there’s a high prevalence of undiagnosed and untreated patients.

Nowadays it's clearly recognized as OSA is a risk factor for hypertension, heart failure, coronary artery disease, and so on.

Sleep fragmentation in patients with sleep apnea can also lead to neurocognitive and behavioral consequences.

Given your experience in the field, I do hope you will consider submitting an article. In this Special Issue, original research article and reviews are welcome.

Best wishes.

Prof. Dr. Graziano Montaruli
Prof. Dr. Domenico Ciavarella
Prof. Dr. Michele Tepedino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstructive sleep apnea (OSA)
  • apnea-hypopnea index (AHI)
  • oxygen desaturation index (ODI)
  • mandibular advancement device (MAD)
  • polysomnography
  • upper airway
  • continuous positive airway pressure (C-PAP)

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Published Papers (1 paper)

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Research

12 pages, 1123 KB  
Article
Impact of Mandibular Advancement Therapy on Occlusal Plane Orientation and Incisor Inclination in Obstructive Sleep Apnea Patients: A Retrospective Observational Study
by Mauro Lorusso, Michele Tepedino, Francesca Papa, Graziano Montaruli, Fariba Esperouz, Rossella Luciano, Giuseppe Burlon, Mario Dioguardi, Lucio Lo Russo and Domenico Ciavarella
J. Clin. Med. 2025, 14(23), 8309; https://doi.org/10.3390/jcm14238309 - 22 Nov 2025
Viewed by 496
Abstract
Objective: This observational study aimed to evaluate occlusal changes in patients with obstructive sleep apnea (OSA) treated with a mandibular advancement device after two years of therapy. Methods: Sixty adult patients with mild to moderate OSA (apnea–hypopnea index 15–30 events/h) were treated with [...] Read more.
Objective: This observational study aimed to evaluate occlusal changes in patients with obstructive sleep apnea (OSA) treated with a mandibular advancement device after two years of therapy. Methods: Sixty adult patients with mild to moderate OSA (apnea–hypopnea index 15–30 events/h) were treated with the IMYS MAD for 24 months. Digital dental impressions were analyzed using Autodesk Meshmixer and Fusion 360 to measure sagittal, frontal, and occlusal angles, as well as upper incisor inclination at baseline (T0) and after treatment (T1). In addition, changes in the polysomnographic indices AHI and ODI were evaluated. Statistical analyses were performed using paired t-tests or Wilcoxon signed-rank tests depending on data normality (p < 0.05). Results: No significant differences were found between T0 and T1 in sagittal (IC 95% −2.053,1.433), occlusal (IC 95%, −1.202, 0.722) or frontal angles (IC 95% −1.487, 0.447), or in upper incisor inclination (IC 95%, 0.06,3.04). Polysomnographic parameters improved significantly, with mean AHI decreasing from 27.7 ± 12.3 (IC 95% 24.53–30.87) to 6.2 ± 4.0 events/h (IC 95% 5.17–7.27) and ODI from 19.7 ± 9.4 (IC 95% 17.27–22.13) to 4.7 ± 3.2 (IC 95% 3.82–5.48, p < 0.001). Conclusions: This study found that the IMYS MAD did not induce significant variations in occlusal plane orientation or upper incisors inclination after two years of treatment. These null findings suggest that the IMYS device may provide effective OSA management while minimizing the risk of occlusal or dental side effects. However, the retrospective design and the 24-month follow-up duration should be taken into consideration. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome)
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