Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
2.9
Journals
JCM
Special Issues
Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications
jcm-logo
Submit to Special Issue Submit Abstract to Special Issue Review for JCM Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 1680

Special Issue Editor

Dr. Dilhana S. Badurdeen

E-Mail Website
Guest Editor
Division of Gastroenterology and Hepatology, Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA
Interests: obesity; MASLD; weight regain after bariatric surgery; organoids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue brings together leading experts in gastroenterology, hepatology, and metabolic surgery to address the pressing challenges of obesity and its management through bariatric interventions. With obesity now affecting more than 650 million adults worldwide and driving comorbidities such as type 2 diabetes, cardiovascular disease, and MASLD/MASH, bariatric surgery remains the most effective therapy for sustained weight loss and metabolic improvement. However, outcomes vary widely, and understanding the predictors of success and the spectrum of complications is critical to advancing patient care.

The issue highlights cutting-edge research on predictors of surgical response, including emerging roles of intestinal adaptation, nutrient sensing, and metabolic phenotyping. Longitudinal studies on weight loss trajectories, diabetes remission, and quality of life provide updated benchmarks for patient counseling. Equally important, the issue covers early and late complications—such as leaks, strictures, malnutrition, and hypoglycemia—and explores endoscopic and surgical strategies for management, reinforcing the importance of multidisciplinary care.

Finally, the collection emphasizes precision medicine approaches to obesity care, including the integration of biomarkers, advanced imaging, and digital health technologies to optimize patient selection and long-term monitoring. By balancing benefits with risks, this issue provides a comprehensive resource for clinicians, researchers, and trainees committed to improving outcomes in obesity and bariatric surgery. It underscores the need for innovation, collaboration, and evidence-based practice to reduce complications while extending the life-saving benefits of these interventions to a broader patient population.

Dr. Dilhana S. Badurdeen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • bariatric surgery
  • metabolic surgery
  • Roux-en-Y Gastric Bypass (RYGB)
  • sleeve gastrectomy
  • revisional bariatric surgery
  • complications
  • outcomes
  • weight loss maintenance
  • metabolic syndrome
  • type 2 diabetes remission
  • nutritional deficiencies
  • gastrointestinal adaptation
  • quality of life
  • long-term follow-up

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

20 pages, 1229 KB  
Article
Long-Term Metabolic Remission and Predictive Factors After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass in an Asian Population
by Kanittha Sakolprakaikit, Kamthorn Yolsuriyanwong, Siripong Cheewatanakornkul, Piyanun Wangkulangkul, Rattana Leelawattana, Pirun Saelue, Darawan Promchan and Praisuda Bualoy
J. Clin. Med. 2026, 15(4), 1539; https://doi.org/10.3390/jcm15041539 - 15 Feb 2026
Viewed by 755
Abstract
Background/Objective: Bariatric surgery is an established treatment for individuals with severe obesity, providing sustained weight loss and improvement in obesity-related comorbidities. However, evidence on long-term outcomes and predictors of metabolic resolution, particularly among Asian populations, remains limited. We aimed to evaluate metabolic outcomes [...] Read more.
Background/Objective: Bariatric surgery is an established treatment for individuals with severe obesity, providing sustained weight loss and improvement in obesity-related comorbidities. However, evidence on long-term outcomes and predictors of metabolic resolution, particularly among Asian populations, remains limited. We aimed to evaluate metabolic outcomes after bariatric surgery and identify predictive factors associated with remission. Methods: We retrospectively reviewed the data of 581 patients who underwent laparoscopic sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) at a tertiary care center between January 2012 and December 2022. Surgical techniques, postoperative follow-up, and baseline characteristics were recorded. Remission and improvement of metabolic comorbidities were assessed during 1–5 years of follow-up. Predictive factors were analyzed, and remission rates between SG and RYGB were compared using propensity score matching. Results: A total of 154 (26.5%) individuals had type 2 diabetes mellitus (T2DM), 162 (27.8%) hypertension (HT), 173 (29.7%) dyslipidemia (DLP), and 407 (70.0%) metabolic syndrome (MetS). Remission occurred in 79.1% of individuals with T2DM, 36.0% with HT, 33.9% with DLP, and 79.6% with MetS. Predictive factors included T2DM duration < 3 years, younger age for HT and DLP remission, male sex, body mass index < 43 kg/m2, and fasting blood glucose level < 126 mg/dL for MetS. RYGB achieved higher remission of DLP than did SG, whereas other outcomes were comparable. Conclusions: Bariatric surgery effectively improves metabolic comorbidities, and several predictive factors influence outcomes. RYGB resulted in superior remission of DLP, while other metabolic outcomes were comparable between the two procedures. Full article
(This article belongs to the Special Issue Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications)
►▼ Show Figures

Figure 1

15 pages, 2087 KB  
Article
Impact of Bariatric Surgery on Post-Transplant Outcomes in Solid Organ Recipients: A Retrospective Cohort Study
by Leandro Sierra, Kanisha Bahierathan, Maria Ortega Abad, Akash Khurana, Arjun Chatterjee, Roma Patel, Stephen Firkins and Roberto Simons-Linares
J. Clin. Med. 2026, 15(3), 954; https://doi.org/10.3390/jcm15030954 - 24 Jan 2026
Viewed by 470
Abstract
Background/Objectives: Obesity affects over 40% of solid organ transplant candidates, increasing graft complications. Bariatric surgery remains underutilized in this population due to safety concerns. We sought to evaluate predictors of graft success among patients with and without a history of bariatric surgery. Methods: [...] Read more.
Background/Objectives: Obesity affects over 40% of solid organ transplant candidates, increasing graft complications. Bariatric surgery remains underutilized in this population due to safety concerns. We sought to evaluate predictors of graft success among patients with and without a history of bariatric surgery. Methods: We utilized the Nationwide Inpatient Sample (2015–2020) to identify adult solid organ transplant recipients with or without a history of bariatric surgery. Propensity score matching (2:1) was performed. The primary outcome was a composite of graft-related complications, including acute or chronic rejection, graft failure, and organ-specific transplant complications. Results: Among 196,871 transplant recipients, 2670 (1.4%) had a bariatric surgery history. After matching, 2530 bariatric surgery patients (age 55.6 ± 11.3 years, 37.5% female, 29.0% obese) were compared with 4817 controls (age 56.3 ± 13.9 years, 36.0% female. 29.1% obese). Bariatric surgery patients had significantly lower composite graft complications (7.7% vs. 10.5%; p < 0.001), driven by reductions in chronic graft rejection (2.1% vs. 3.1%; p = 0.01), kidney complications (6.2% vs. 8.4%; p < 0.001), and pancreas complications (0.2% vs. 0.6%; p = 0.004). Multivariate analysis showed bariatric surgery was independently associated with 23% reduced odds of graft complications (OR 0.77; 95% CI 0.61–0.96; p = 0.02). Conclusions: Bariatric surgery was independently associated with reduced graft-related complications in solid organ transplant recipients, supporting its role in improving post-transplant outcomes. Future studies should define the optimal timing of bariatric surgery relative to transplantation. Full article
(This article belongs to the Special Issue Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications)
►▼ Show Figures

Figure 1

Other

Jump to: Research

13 pages, 1315 KB  
Systematic Review
Laparoscopic Sleeve Gastrectomy Versus One-Anastomosis Gastric Bypass and the Risk of De Novo or Persistent Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis
by Wisam Jamal and Moaz Abulfaraj
J. Clin. Med. 2026, 15(9), 3354; https://doi.org/10.3390/jcm15093354 - 28 Apr 2026
Viewed by 87
Abstract
Background/Objectives: Laparoscopic sleeve gastrectomy (LSG) is the most frequently performed bariatric procedure worldwide; one-anastomosis gastric bypass (OAGB) ranks third. Gastroesophageal reflux disease (GERD) may develop de novo or worsen following either procedure. This systematic review and meta-analysis aimed to compare postoperative GERD outcomes—overall, [...] Read more.
Background/Objectives: Laparoscopic sleeve gastrectomy (LSG) is the most frequently performed bariatric procedure worldwide; one-anastomosis gastric bypass (OAGB) ranks third. Gastroesophageal reflux disease (GERD) may develop de novo or worsen following either procedure. This systematic review and meta-analysis aimed to compare postoperative GERD outcomes—overall, de novo, and persistent—between LSG and OAGB. Methods: A PRISMA-compliant systematic review and meta-analysis were conducted. PubMed, Embase, the Cochrane Library, and Web of Science were searched for studies published between January 2000 and December 2025. A random-effects model was applied for the meta-analysis. Results: A total of 847 articles were identified. Among them, 15 primary studies met the inclusion criteria (four randomized controlled trials and 11 observational studies involving approximately 1800 LSG and 2450 OAGB patients). LSG was associated with a significantly higher risk of overall GERD (OR, 3.67; 95% CI, 2.54–5.30; p < 0.001; I2 = 55%), de novo GERD (OR, 4.12; 95% CI, 2.54–6.69; p < 0.001; I2 = 44%), and persistent or worsening GERD (OR, 2.67; 95% CI, 1.34–5.32; p = 0.005; I2 = 38%). Hiatal hernia was reported in only four studies; bile reflux was paradoxically higher after LSG than OAGB (74.7% vs. 12.5%). Conclusions: LSG carries significantly higher postoperative GERD risk than OAGB across all evaluated outcomes. Although Roux-en-Y gastric bypass remains the gold standard for bariatric patients requiring GERD control, OAGB represents a well-supported alternative that outperforms LSG in reflux-related outcomes and should be favored when GERD is a clinical concern. Full article
(This article belongs to the Special Issue Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop