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Clinical Advances and Challenges in Vascular and Endovascular Medicine: 2nd Edition

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Vascular Medicine".

Deadline for manuscript submissions: 25 November 2026 | Viewed by 1264

Editor


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Guest Editor
Division of Vascular Surgery, Department of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia, 25123 Brescia, Italy
Interests: vascular surgery; vascular medicine; stents; aortic diseases; vascular diseases; medical and biomedical image processing; angi-ography; atherosclerosis
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Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “Clinical Advances and Challenges in Vascular and Endovascular Medicine: 2nd Edition”. This is a new edition; we published seven papers in the first edition. For more details, please visit https://www.mdpi.com/journal/jcm/special_issues/I2WQD52AQM.

Vascular and endovascular medicine are specialized fields of medicine that focus on the diagnosis, treatment, and management of diseases affecting the blood vessels. Endovascular treatments such as angioplasty, stenting, and embolization have revolutionized the treatment of vascular diseases, reducing the need for open surgery and improving patient recovery times. Recent clinical advances in vascular imaging technologies, such as CT angiography and magnetic resonance imaging (MRI), have improved the accuracy of diagnosis, allowing for earlier detection and treatment of vascular disease. However, these advances have also brought challenges, including the development of better preventative measures and more effective treatments for vascular diseases such as arterial aneurysms, peripheral artery disease, and venous thromboembolism.

In conclusion, while recent clinical advances in vascular and endovascular medicine have greatly improved patient outcomes, they have also introduced new challenges that will require ongoing attention from the medical community. Addressing these challenges will require continued innovation, research, and collaboration among practitioners in these fields. We look forward to your enthusiastic participation in this Special Issue that will promote scientific communication of our knowledge with the ultimate goal of positively influencing treatment and care for our patients.

Dr. Luca Bertoglio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vascular and endovascular medicine
  • minimally invasive cardiovascular surgery
  • vascular diseases
  • endovascular technologies

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Related Special Issue

Published Papers (2 papers)

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Research

18 pages, 1827 KB  
Article
Impact of Postoperative Antithrombotic Treatment on Patency and Survival After Open Posterior Popliteal Artery Aneurysm Repair: A Multicenter Retrospective Cohort Analysis from the PARADE Study
by Giorgio Prouse, Giulia Bertagna, Francesco Andreoli, Maria Antonella Ruffino, Valentina Scarati, Raffaella Berchiolli, Stefanie Hayoz, Mariacarla Andreozzi, Alessandro Robaldo and Nicola Troisi
J. Clin. Med. 2026, 15(14), 5364; https://doi.org/10.3390/jcm15145364 - 9 Jul 2026
Viewed by 363
Abstract
Background/Objectives: This study assessed the impact of different postoperative antithrombotic strategies on graft patency and overall survival after open posterior repair of popliteal artery aneurysms (PAAs). Methods: A retrospectively maintained dataset of consecutive PAAs electively treated in 40 centers between January [...] Read more.
Background/Objectives: This study assessed the impact of different postoperative antithrombotic strategies on graft patency and overall survival after open posterior repair of popliteal artery aneurysms (PAAs). Methods: A retrospectively maintained dataset of consecutive PAAs electively treated in 40 centers between January 2010 and December 2023 was analyzed. The study included patients undergoing elective open posterior repair. Primary outcomes were primary patency and overall survival according to postoperative antiplatelet or anticoagulant therapy. Secondary outcomes included secondary patency and major adverse cardiovascular events (MACEs). Kaplan–Meier analysis, log-rank testing, and Cox regression models were applied. Results: Overall, 638 patients were included. The cohort was predominantly male (96%), with a median age of 70 years. At 30 days, one death (0.2%) and seven MACEs (1.1%) occurred. Postoperative therapy was not associated with 30-day primary patency or MACEs. At a median follow-up of 30 months, overall survival was 90.3%. Kaplan–Meier analysis showed comparable overall survival across antithrombotic regimens, with a significant difference observed only between patients receiving combined anticoagulant and antiplatelet therapy and those receiving other regimens (p = 0.018). No differences emerged between vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs), nor between single or dual antiplatelet therapy and anticoagulation. Multivariable Cox regression showed that combined therapy was associated with poorer overall survival compared with other postoperative antithrombotic regimens (CT vs. others: HR of 1.30). Primary and secondary patency were also similar among regimens except for combined therapy (primary patency: p = 0.004; secondary patency: p = 0.018). Conclusions: Postoperative medical therapy was not associated with 30-day outcomes. During long-term follow-up, overall survival and graft patency were lower in patients receiving combined anticoagulant and antiplatelet therapy. Bleeding outcomes were not captured in this registry; as bleeding may contribute to the worse outcomes observed with combined therapy, this represents an important limitation. Full article
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15 pages, 741 KB  
Article
A Conceptual Wound-Oriented Reinterpretation of Perfusion Heterogeneity in Chronic Limb-Threatening Ischemia
by Mircea Ionut Popitiu, Lorenzo Patrone, Giacomo Clerici, Serban Comsa, Gloria Gavrila-Ardelean, Nilima Rajpal Kundnani, Nicu Olariu and Mihai Edmond Ionac
J. Clin. Med. 2026, 15(11), 4119; https://doi.org/10.3390/jcm15114119 - 26 May 2026
Viewed by 391
Abstract
Background/Objectives: The angiosome concept is widely used to guide infrapopliteal revascularization in patients with chronic limb-threatening ischemia (CLTI). However, clinical outcomes are not always fully explained by anatomical target-artery alignment alone. The present study aimed to revisit a previously published angiosome-based cohort through [...] Read more.
Background/Objectives: The angiosome concept is widely used to guide infrapopliteal revascularization in patients with chronic limb-threatening ischemia (CLTI). However, clinical outcomes are not always fully explained by anatomical target-artery alignment alone. The present study aimed to revisit a previously published angiosome-based cohort through a wound-oriented conceptual perspective and to explore whether perfusion heterogeneity may help contextualize variability in clinical outcomes. Methods: This retrospective secondary analysis included 51 patients with CLTI who underwent infrapopliteal endovascular revascularization. Patients were originally classified as direct, indirect, or mixed revascularization according to angiosome-based criteria. The present study represents an exploratory conceptual reinterpretation of the original dataset. No new variables were introduced, and the woundosome concept was not operationalized as a measurable patient-level variable. Statistical analyses were exploratory and descriptive in nature. Results: High rates of wound healing and limb salvage were observed across all revascularization patterns at 12 months. Within the limitations of this small exploratory cohort, no consistent detectable differences in clinical outcomes were observed across anatomical revascularization patterns. Stratification according to the number of affected angiosomes did not reveal clear outcome differences. The findings suggest that factors beyond anatomical target-artery alignment may contribute to wound healing variability in CLTI. Conclusions: The present study does not establish a validated wound-oriented perfusion model but highlights the limitations of relying exclusively on anatomical angiosome classification when interpreting clinical outcomes in CLTI. In this context, the woundosome may serve as a descriptive and hypothesis-generating conceptual framework for discussing perfusion heterogeneity and wound-level perfusion complexity. Prospective studies integrating objective perfusion assessment and standardized wound evaluation are required. Full article
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