Alcohol-Associated Liver Disease: Diagnosis and Treatment of Acute and Chronic Conditions
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 20 May 2026 | Viewed by 44
Special Issue Editors
Interests: liver diseases; biliary tract diseases; diagnostic and procedural endoscopy; digestive system pathologies in pregnancy; gastroenterology; internal medicine
Interests: alcohol-associated liver disease; chronic liver diseases; portal hypertension; liver cirrhosis; endoscopy
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Special Issue Information
Dear Colleagues,
Excessive alcohol intake causes complex damage to the liver and extrahepatic organs of the body, including the brain, pancreas, heart, adipose tissue, muscles, and gastrointestinal tract. As reported by the World Health Organization (WHO), global alcohol consumption is increasing, creating a significant economic, social, and health problem worldwide. According to the WHO’s Global Status Report on Alcohol and Health 2018, in 2016, about 3 million deaths (4% of all deaths) were attributed to alcohol worldwide. A range of mechanisms are involved in the pathogenesis of ethanol-related liver injury; however, they remain incompletely understood. Emerging strategies focus on counteracting oxidative stress, modulating inflammatory and immune signaling, restoring gut–liver homeostasis, and regenerating damaged hepatocytes (i.e., mesenchymal stem cells). Despite intensive research, there is no approved therapy for alcohol-associated liver disease (ALD). Given the heterogeneity of ALD, a multidisciplinary approach addressing metabolism, immunity, and multiorgan crosstalk is essential in mitigating the harmful effects of ethanol and improving patient outcomes.
This Special Issue will highlight the complex impacts of ethanol on the liver and further interactions with extrahepatic organs, as well as potential new diagnostic approaches and therapeutic targets. We warmly invite researchers to submit original research articles and/or reviews in order to widen our knowledge of the complex pathogenesis of ALD and its implications for human health.
We look forward to receiving your contributions.
Kind regards,
Prof. Dr. Halina Cichoz-Lach
Prof. Dr. Beata Kasztelan-Szczerbińska
Guest Editors
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Keywords
- alcohol-associated liver disease
- alcohol-associated hepatitis
- alcohol-associated liver cirrhosis
- excessive alcohol intake
- oxidative liver damage
- gut–liver axis
- organ-to-organ crosstalk
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