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Journal of Clinical Medicine, Volume 14, Issue 18

September-2 2025 - 341 articles

Cover Story: Chronic lung allograft dysfunction (CLAD) occurs in up to 50% of patients within the first five years after lung transplantation (LuTX) and represents the main complication and cause of death regarding this surgery. Alveolar septal widening in transbronchial biopsies has shown an association with acute humoral allograft rejection. We retrospectively analyzed transbronchial biopsies taken at three time points from 57 patients who underwent LuTX between February 2010 and July 2019, 26 of whom developed CLAD up to November 2022. The biopsies were analyzed by microscopic morphometry and quantitative reverse transcription PCR to identify predictors of CLAD. We aimed to explore histological markers that could predict the development of CLAD before its clinical manifestation. View this paper
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Articles (341)

  • Article
  • Open Access
512 Views
11 Pages

22 September 2025

Background/Objectives: Textbook outcome (TO) is a composite quality measure in surgery, but few studies have compared TO between robotic pancreaticoduodenectomy (RPD) and laparoscopic pancreaticoduodenectomy (LPD). This study aimed to evaluate and co...

  • Review
  • Open Access
1,359 Views
26 Pages

22 September 2025

Recurrence of the original glomerular disease (GN) poses a significant threat to kidney transplant function and longevity. The probability and severity of this recurrence vary, with C3 glomerulopathy and certain forms of FSGS exhibiting particularly...

  • Article
  • Open Access
2 Citations
470 Views
12 Pages

22 September 2025

Background/Objectives: Intraoperative aberrometry has gained clinical relevance in correcting aberrations during cataract and corneal refractive surgeries. As wavefront aberrations are typically measured with patients seated, while surgeries are perf...

  • Systematic Review
  • Open Access
502 Views
17 Pages

22 September 2025

Background and Aims: Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) or biopsy (FNB) is the standard method for diagnosing abdominal masses, but sample inadequacy and diagnostic accuracy remain challenges. Conventional smear (CS) and...

  • Article
  • Open Access
1 Citations
483 Views
16 Pages

Impact of Surgical Delay on Two-Stage Breast Reconstruction During the COVID-19 Pandemic: A Retrospective Analysis

  • Ferruccio Paganini,
  • Elisa Bascialla,
  • Beatrice Corsini,
  • Chiara Truini,
  • Monica Arcaini,
  • Lorenzo Fresta,
  • Federico Lo Torto,
  • Marco Marcasciano,
  • Sara Matarazzo and
  • Diego Ribuffo
  • + 1 author

22 September 2025

Background: The COVID-19 pandemic caused unprecedented delays in elective surgery, including breast reconstruction, prolonging expander retention beyond recommended timelines. Methods: We retrospectively compared patients who underwent two-stage expa...

  • Review
  • Open Access
2,298 Views
19 Pages

Interventional Management of Acute Pancreatitis and Its Complications

  • Muaaz Masood,
  • Amar Vedamurthy,
  • Rajesh Krishnamoorthi,
  • Shayan Irani,
  • Mehran Fotoohi and
  • Richard Kozarek

22 September 2025

Acute pancreatitis (AP) is the most common cause of gastrointestinal-related hospitalizations in the United States, with gallstone disease and alcohol as the leading etiologies. Management is determined by disease severity, classified as interstitial...

  • Article
  • Open Access
521 Views
13 Pages

Clinical Impact of External Carotid Artery Remodeling Following Carotid Artery Stenting

  • Dorota Łyko-Morawska,
  • Michał Serafin,
  • Julia Szostek,
  • Magdalena Mąka,
  • Iga Kania and
  • Wacław Kuczmik

22 September 2025

Background: Carotid artery stenting (CAS) is a common revascularization approach for carotid artery stenosis. While its impact on the internal carotid artery (ICA) has been extensively studied, the effects on the external carotid artery (ECA)—a...

  • Article
  • Open Access
2,706 Views
12 Pages

Nurse Specialising Consultation in Heart Failure: Impact on Drug Titration and Cardiovascular Events in Patients with Heart Failure and Reduced Ejection Fraction

  • Jose Lopez-Aguilera,
  • Jorge Perea-Armijo,
  • Ana Belen Muñoz-Villarreal,
  • Antonia Cepas-Sosa,
  • Luisa Maria Luque-Serrano,
  • Nerea Aguayo-Caño,
  • Gloria Maria Heredia-Campos,
  • Juan Diego Martin-Diaz,
  • Rafael Gonzalez-Manzanares and
  • Juan Carlos Castillo-Dominguez
  • + 6 authors

22 September 2025

Introduction: The increasingly active role of nurses in the management of heart failure (HF) has become important in HF units (HCUs). This study aims to determine the effect of opening a specialised HF nursing (NSHF) consultation in a tertiary hospit...

  • Systematic Review
  • Open Access
1,021 Views
17 Pages

Immune Checkpoint Inhibitors Beyond Progression in Various Solid Tumors: A Systematic Review and Pooled Analysis

  • Fausto Petrelli,
  • Antonio Ghidini,
  • Maria Chiara Parati,
  • Karen Borgonovo,
  • Mauro Rossitto,
  • Mara Ghilardi,
  • Giuseppina Dognini,
  • Daniela Petro’,
  • Irene Angeli and
  • Veronica Lonati
  • + 2 authors

22 September 2025

Background: Immune checkpoint inhibitors (ICIs) have transformed outcomes in advanced cancers; however, the value of continuing treatment after radiologic progression remains uncertain. We systematically assessed the efficacy and safety of ICI contin...

  • Study Protocol
  • Open Access
488 Views
25 Pages

22 September 2025

Background/Objectives: As global aging accelerates, there is a pressing and empirically substantiated demand for integrated and sustainable strategies, as evidenced by the rising prevalence rates of chronic conditions, social isolation, and digital e...

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J. Clin. Med. - ISSN 2077-0383Creative Common CC BY license