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Acute Coronary Syndromes | Circulation Research

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 146

Special Issue Editors


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Guest Editor
Center for Clinical Research and Education, Curtin School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia
Interests: coronary artery disease; interventional cardiology; thrombosis; precision medicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Istituto Nazionale di Ricerche Cardiovasolari (INRC), Via Irnerio, 48-40126 Bologna, Italy
Interests: arterial hypertension; cardiovascular risk factors; cardiovascular prevention; congestive heart failure; metabolic syndrome; cardiovascular pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acute Coronary Syndromes (ACS) remain a leading cause of morbidity and mortality worldwide, representing a critical area in cardiovascular medicine where rapid advances in research and innovation can translate into lifesaving improvements in care. Over recent decades, significant progress has been made in understanding the complex pathophysiology of ACS, refining diagnostic strategies, and optimizing both pharmacologic and interventional therapies. Despite these advances, important challenges persist, such as residual risk, complications of therapy, disparities in access to care, and outcomes in understudied populations.

The aim of this Special Issue is to highlight cutting-edge research that addresses these challenges and advances our understanding of ACS. We invite original research, state-of-the-art reviews and meta-analyses focused on the latest evidence and emerging strategies for the prevention, diagnosis, and management of ACS.

Topics of interest include, but are not limited to:

  • Novel biomarkers and imaging modalities for early detection and risk stratification
  • Advances in cardiovascular therapy and personalized medicine
  • Innovative interventional and pharmacological approaches
  • Mechanistic insights into plaque rupture, thrombosis, and microvascular dysfunction
  • Management of special and high-risk populations (e.g., women, older adults, patients with diabetes or chronic kidney disease)
  • Real-world implementation, health systems strategies, and disparities in ACS care

We look forward to receiving your contributions that will help shape the future of ACS research and clinical practice.

Dr. Leslie Marisol Lugo Gavidia
Prof. Dr. Roberto Pedrinelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute coronary syndromes
  • cardiovascular risk
  • individualized therapy
  • STEMI
  • risk factors

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Published Papers (1 paper)

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Research

16 pages, 1155 KB  
Article
Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score as a Novel Biomarker for Predicting Coronary Slow Flow in Patients with Angina and/or Ischemia and Nonobstructive Coronary Arteries
by Çağatay Tunca, Reha Yasin Şengül, Mehmet Taha Özkan, Alperen Taş, Yusuf Bozkurt Şahin, Saadet Demirtaş İnci, Veysel Ozan Tanık and Bülent Özlek
J. Clin. Med. 2026, 15(3), 1302; https://doi.org/10.3390/jcm15031302 - 6 Feb 2026
Abstract
Background: The coronary slow flow phenomenon (CSFP) is an angiographic entity increasingly recognized in patients with angina and/or ischemia but non-obstructive coronary arteries (ANOCA/INOCA), associated with systemic inflammation, endothelial dysfunction, and microvascular abnormalities. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a [...] Read more.
Background: The coronary slow flow phenomenon (CSFP) is an angiographic entity increasingly recognized in patients with angina and/or ischemia but non-obstructive coronary arteries (ANOCA/INOCA), associated with systemic inflammation, endothelial dysfunction, and microvascular abnormalities. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel immunonutritional index that may reflect this multifactorial risk profile. Methods: This retrospective single-center case–control study included 122 patients with CSFP and 126 age- and sex-matched controls with normal coronary flow, all presenting with symptoms of chronic coronary syndrome. CSFP was diagnosed via corrected TIMI frame count. HALP and other inflammatory indices (NLR, PLR, SII, SIRI) were calculated from baseline laboratory values. Associations were evaluated using multivariable logistic regression, ROC analysis, and restricted cubic spline (RCS) modeling. Results: The HALP score was significantly lower in CSFP patients (mean 56.2 vs. 65.9, p < 0.001). In multivariable analysis, HALP was independently associated with CSFP (adjusted OR: 0.951; 95% CI: 0.930–0.972; p < 0.001), whereas NLR lost significance. PLR, SII, and SIRI remained independently associated. HALP showed the highest diagnostic performance (AUC: 0.698), significantly outperforming all other indices (DeLong p < 0.001). A HALP cutoff ≤ 56.4 provided 58.2% sensitivity and 77.0% specificity. RCS analysis demonstrated a significant non-linear inverse relationship (p for non-linearity = 0.034). Subgroup analyses confirmed consistent associations across age, sex, hypertension, and diabetes strata. Conclusions: The HALP score is independently associated with CSFP and outperforms traditional inflammatory indices. Its low cost and accessibility make it a promising tool for clinical risk stratification in ANOCA/INOCA patients, pending validation in multicenter prospective studies. Full article
(This article belongs to the Special Issue Acute Coronary Syndromes | Circulation Research)
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