The Management of Chronic Cholestatic Diseases
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 24 November 2026 | Viewed by 168
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic cholestatic liver diseases are chronic diseases affecting cholangiocytes, the cells lining the biliary tree, characterized by inflammation, destruction or reduction of the bile ducts (intra- or extrahepatic), and consequent cholestasis.
The management of these diseases represents a complex and evolving challenge in hepatology. Conditions such as Primary Biliary Cholangitis and Primary Sclerosing Cholangitis are characterized by a frequently progressive course, a significant impact on patients’ quality of life, and a risk of progression to advanced fibrosis, cirrhosis, and cholangiocarcinoma. In recent years, major advances in our understanding of disease pathogenesis—including immune-mediated mechanisms, alterations in bile acid signaling, and interactions with the gut microbiota—have opened up new diagnostic and therapeutic perspectives. At the same time, the development of novel pharmacological strategies and the optimization of existing treatments are reshaping the goals of clinical management, with increasing attention given to personalized medicine and surrogate endpoints of therapeutic response. Finally, in recent years, genetically cholestatic liver diseases have also been investigated in adult patients with cholestasis of unknown origin.
This Special Issue will provide an updated overview of recent advances in the diagnosis, monitoring, and treatment of chronic cholestatic diseases. By showcasing original contributions, this Special Issue will foster dialogue between basic research and clinical practice, ultimately promoting innovative strategies to improve outcomes for patients affected by these conditions.
Dr. Maria Consiglia Bragazzi
Guest Editor
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Keywords
- chronic cholestatic liver diseases
- cholestasis
- primary biliary cholangitis
- primary sclerosing cholangitis
- cholangiocar-cinoma
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