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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and Stefan Motov

submission deadline 28 Nov 2025 | Viewed by 126 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care

edited by

Marco Scarci

and

Savvas Lampridis

submission deadline 28 Nov 2025 | Viewed by 50 | Submission Open

Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Current Practices in Cardiovascular Perfusion and Recovery

edited by

Irbaz Hameed

submission deadline 28 Nov 2025 | Viewed by 42 | Submission Open

Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation

(This special issue belongs to the Section Cardiology)

Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract

edited by

Adam Fabisiak

and Hubert Zatorski

submission deadline 28 Nov 2025 | Viewed by 42 | Submission Open

Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Treatments for Vestibular Migraine

edited by

Teru Kamogashira

submission deadline 28 Nov 2025 | Viewed by 40 | Submission Open

Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies

(This special issue belongs to the Section Otolaryngology)

Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition

edited by Alexandre Hardy and Nicolas Bouguennec

submission deadline 28 Nov 2025 | Viewed by 40 | Submission Open

Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure

(This special issue belongs to the Section Sports Medicine)

Clinical Updates in Heart Transplantation

edited by

Giacomo Bianchi

submission deadline 28 Nov 2025 | Viewed by 39 | Submission Open

Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease

(This special issue belongs to the Section Cardiology)

State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery

edited by

Pantelis Antonakis

and Konstantinos Bramis

submission deadline 28 Nov 2025 | Viewed by 30 | Submission Open

Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances of Breast Surgery and Reconstruction

edited by

Glenda Giorgia Caputo

and Emanuele Cigna

submission deadline 30 Nov 2025 | Viewed by 620 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Innovative Technologies and Approaches in Eye Disease Management and Refractive Surgery

edited by

Hidenaga Kobashi

submission deadline 30 Nov 2025 | Viewed by 569 | Submission Open

Keywords: multifocal intraocular lenses; femtosecond lasers; artificial intelligence; imaging; eye surgery; refractive surgery

(This special issue belongs to the Section Ophthalmology)

Clinical Application of Knee Arthroscopy

edited by

Francesco Bosco

and Alessandro Carrozzo

submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open

Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation

(This special issue belongs to the Section Orthopedics)

Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases

edited by Sotiria Palioura, Carolina L. Mercado and Jaime D. Martinez

submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open

Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques

(This special issue belongs to the Section Ophthalmology)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 30 Nov 2025 | Viewed by 105 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care

edited by

Keiichi Hirono

submission deadline 30 Nov 2025 | Viewed by 80 | Submission Open

Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging

(This special issue belongs to the Section Cardiology)

Recent Progress in Rehabilitation Medicine—3rd Edition

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | Viewed by 79 | Submission Open

Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life

(This special issue belongs to the Section Clinical Rehabilitation)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 30 Nov 2025 | Viewed by 75 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Role of Platelet in Inflammation, Infection, and Immune Response

edited by

Amir Houshang Shemirani

submission deadline 30 Nov 2025 | Viewed by 69 | Submission Open

Keywords: platelets; platelet count; dual antiplatelet therapy; inflammation; thrombosis; inflammation; hemostasis; immune response

(This special issue belongs to the Section Hematology)

Current Challenges in Orthopedic Trauma Surgery

edited by Pietro Maniscalco and Fabrizio Quattrini

submission deadline 30 Nov 2025 | Viewed by 66 | Submission Open

Keywords: hip replacement; knee replacement; shoulder replacement; ankle replacement; trauma surgery; femur; future chal-lenges; surgical innovations

(This special issue belongs to the Section Orthopedics)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 30 Nov 2025 | Viewed by 66 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Ischemic Stroke: Diagnosis and Treatment

edited by

Theodoros Karapanayiotides

and

Ioanna Koutroulou

submission deadline 30 Nov 2025 | Viewed by 64 | Submission Open

Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy

(This special issue belongs to the Section Clinical Neurology)

Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | Viewed by 62 | Submission Open

Keywords: heart; lung; kidney; liver; bone; brain

(This special issue belongs to the Section Clinical Rehabilitation)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 30 Nov 2025 | Viewed by 58 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by Alfredo Papa and Loris Riccardo Lopetuso

submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthodontics: State of the Art and Prospects

edited by Beatriz Tarazona-Álvarez and

Natalia Zamora-Martínez

submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open

Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights into Acne Vulgaris Treatment and Management Strategies

edited by Jo Linda Maria Sinagra

submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open

Keywords: acne; hormonal treatments; isotretinoin; laser therapy; antibiotic

(This special issue belongs to the Section Dermatology)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Novel Insights into the Clinical Management of Retinal Detachment

edited by Francesco Sabatino

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: retinal detachment; oil toxicity; gas tamponade; pars plana vitrectomy; scleral buckle; pneumatic retinopexy; surgical techniques; retinal imaging; retinal displacement

(This special issue belongs to the Section Ophthalmology)

Orthopedic Surgery: Latest Advances and Perspectives

edited by

Mitchell K. Ng

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: motion preservation; pain management; robotics/computer navigation; degenerative disc disease; orthobiologics; arthroplasty; trauma

(This special issue belongs to the Section Orthopedics)

Anesthesia and Perioperative Management of Organ Transplants

edited by

Uzung Yoon

and Ji-Hye Kwon

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension

(This special issue belongs to the Section Anesthesiology)

Novel Aspects of Endocrine Care: From Patient-Centred Management of Endocrine Diseases to Guidelines Standards

edited by

Mara Carsote

and

Claudiu Nistor

submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open

Keywords: endocrine tumour; hormone; biomarker; neuroendocrine tumour; thyroidectomy; parathyroidectomy; bone; ad-renal gland; osteoporosis; pituitary gland; autoimmune; antibody; clinical study; computed tomography

(This special issue belongs to the Section Endocrinology & Metabolism)

Multiparametric Ultrasound Techniques for Liver Disease Assessments

edited by Francesco Giangregorio

submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open

Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Percutaneous Coronary Intervention: Latest Advances and Future Prospects

edited by

Alessandro Mandurino-Mirizzi

submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open

Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease

(This special issue belongs to the Section Cardiology)

Key Quality Indicators in Diagnosis and Treatment of Respiratory Diseases

edited by

Fotios Sampsonas

submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open

Keywords: key quality indicators; respiratory disorders; audit; quality improvement; real-life data

(This special issue belongs to the Section Respiratory Medicine)

Spine Surgery Innovations: Clinically Advanced Treatment and Technologies

edited by Jang W. Yoon

submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open

Keywords: minimally invasive spine surgery; artificial intelligence; wearable biometrics; big data; smartphone accelerometer

(This special issue belongs to the Section Orthopedics)

Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer

edited by Bhaumik Patel

submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open

Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Challenges in the Diagnosis and Treatment of Glaucoma

edited by

Abdelaziz Abdelaal

submission deadline 30 Nov 2025 | Viewed by 45 | Submission Open

Keywords: glaucoma diagnosis; glaucoma progression; glaucoma biomarkers; intraocular pressure (IOP) management; corneal hysteresis; machine learning in glaucoma detection; neuroprotection in glaucoma; surgery and laser therapy

(This special issue belongs to the Section Ophthalmology)

Innovations in Microsurgical Reconstruction: Bridging Challenges in Breast and Limb Reconstruction

edited by Gordon K. Lee,

Sik Namgoong

and

Dung Nguyen

submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open

Keywords: microsurgery; breast reconstruction; limb reconstruction; perforator flaps; super microsurgery; surgical innovation; reconstructive surgery; lymphedema; tissue engineering; diabetic foot reconstruction; wound healing; cell therapy

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities

edited by Gian Marco Prucher,

Andrea Cassoni

and Francesco Arcuri

submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open

Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Interventional Cardiology: Clinical Advances and Future Perspectives

edited by Antonio Landi and

Andrea Milzi

submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open

Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome

(This special issue belongs to the Section Cardiology)

Minimally Invasive Gastrointestinal Surgery: Clinical Advances and Prospects

edited by Jun Suh Lee

submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open

Keywords: minimally invasive surgery; gastrointestinal surgery; laparoscopic surgery; robotic surgery; surgical innovation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest

edited by

Erik Roman-Pognuz

submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open

Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition

edited by Nikos Nikolettos and

Angeliki Tiptiri-Kourpeti

submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open

Keywords: assisted reproduction technology (ART); infertility; treatment; reproduction; IVF

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Thoracic Surgery Between Tradition and Innovations

edited by Jacopo Vannucci

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy

(This special issue belongs to the Section General Surgery)

Kidney Transplantation: Recent Advances and Challenges

edited by Jose Torrealba

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: kidney allograft; pathology; HLA and antibodies; management

(This special issue belongs to the Section Nephrology & Urology)

Thrombotic Risk and Its Management Across Diverse Clinical Settings

edited by Samuel Bogdan Todor and Ana Maria Vlǎdǎreanu

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: thrombosis; thrombotic risk; hematologic disorders; thrombophilia; myeloproliferative neoplasms; antithrombotic therapy; cardiovascular diseases; biomarkers

(This special issue belongs to the Section Hematology)

Clinical Research in Vascular Access Devices

edited by

Antonio Gidaro

submission deadline 30 Nov 2025 | Viewed by 23 | Submission Open

Keywords: short peripheral catheters; long peripheral catheters; midline; peripherally inserted central catheters (PICCs); femoral-inserted central catheters (FICCs); centrally inserted central catheters (CICCs); totally implantable venous access devices (TIVAD); catheter-related bloodstream infection (CRBSI); catheter-associated bloodstream infection (CABSI); central line-associated bloodstream infection (CLABSI); catheter-related thrombosis (CRT); fibroblastic sleeve; infiltration; extravasation

(This special issue belongs to the Section Vascular Medicine)

Transcatheter Aortic Valve Implantation- Clinical Management and Future Challenges

edited by Mohamed Farag

submission deadline 30 Nov 2025 | Viewed by 18 | Submission Open

Keywords: transcatheter aortic valve implantation; TAVI; bicuspid aortic valve; small annulus; prosthesis– patient mismatch; coronary reaccess; valve-in-valve TAVI; leaflet modification

(This special issue belongs to the Section Cardiovascular Medicine)

AI in Maternal Fetal Medicine and Perinatal Management

edited by Ariel Many

submission deadline 5 Dec 2025 | Viewed by 52 | Submission Open

Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction

(This special issue belongs to the Section Obstetrics & Gynecology)

State of the Art: Updates in Preterm Labor and Preterm Birth

edited by

Eran Bornstein

and Moti Gulersen

submission deadline 10 Dec 2025 | 3 articles | Viewed by 2624 | Submission Open

Keywords: prenatal diagnosis; preterm birth; antenatal corticosteroids; cerclage; multiple gestations

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Arthroscopic Shoulder Surgery

edited by Anup Ajit Shah, Michael J. O’Brien and Asheesh Bedi

submission deadline 10 Dec 2025 | Viewed by 295 | Submission Open

Keywords: rotator cuff; biologic tuberoplasty; lower trapezius tendon transfer; arthroscopic Latarjet; arthroscopic bone block; augmentation of the cuff

(This special issue belongs to the Section Orthopedics)

Displaying special issue 1151-1200 on page 24 of 27.

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