Endometrial Disorders and Pregnant Outcome: Clinical Insights and Perspectives
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".
Deadline for manuscript submissions: 15 November 2026 | Viewed by 76
Special Issue Editor
Interests: fertility preservation; endometriosis; assisted reproductive technology; reproductive endocrinology; pregnancy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue redefines the human endometrium as a dynamic microenvironment that integrates microbial, immunological, and metabolic inputs to determine the success of conception. Moving beyond the "sterile womb" dogma, we analyze how this microenvironment is influenced by both external and intrinsic factors within the resident microbiome.
Notably, Lactobacillus depletion drives inflammation, linking dysbiosis not only to Recurrent Implantation Failure (RIF) but to late-stage obstetric complications such as Preeclampsia and Preterm Birth through persistent "inflammatory memory." Moreover, this issue explores how Chronic Endometritis impairs decidualization genes. Furthermore, it is important to examine how Insulin Resistance in Polycystic Ovary Syndrome (PCOS) creates a "hostile soil," while the gut-endometrial axis contributes to the hyperestrogenic state driving Endometriosis and Endometrial Hyperplasia.
By systematizing scientific evidence from pathogenesis to targeted therapy, this Special Issue aims to elucidate common pathways linking these diverse disorders and to advocate precision medicine strategies to restore the critical relationship between the mother and the developing fetus.
Potential topics include (but are not limited to) the following:
Endometrial diseases;
Polycystic Ovary Syndrome;
Pregnancy;
Reproductive endocrinology
Assisted reproductive technology
Dr. Raffaella Di Girolamo
Guest Editor
Manuscript Submission Information
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Keywords
- endometrial microbiome
- fertility preservation
- pregnancy outcome
- reproductive medicine, ART
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