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Revolutionizing Arrhythmia Therapy: Novel Approaches in Pacing and Defibrillation
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Revolutionizing Arrhythmia Therapy: Novel Approaches in Pacing and Defibrillation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 10 May 2026 | Viewed by 598

Special Issue Editors

Dr. Amato Santoro

E-Mail Website
Guest Editor
Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
Interests: conduction system pacing; cardiac resynchronization therapy; biventricular pacing; catheter ablation; left atrial flutter; post cardiac surgery; atrial flutter ablation
Special Issues, Collections and Topics in MDPI journals
Dr. Alberto Palazzuoli

E-Mail Website
Guest Editor
Cardiovascular Diseases Unit, Cardio Thoracic and Vascular Department, Le Scotte Hospital, University of Siena, Viale Bracci 14, 53100 Siena, Italy
Interests: heart failure; right ventricular uncoupling; biomarkers; cardiac resynchronization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of cardiac electrophysiology is undergoing a profound transformation driven by technological innovation and refined pathophysiological understanding. Conventional pacing and defibrillation strategies—long the cornerstone of bradyarrhythmia and sudden death prevention—are now being reshaped by the advent of conduction system pacing, leadless stimulation, subcutaneous and extravascular ICDs, and the integration of advanced imaging and remote monitoring.

This Special Issue highlights recent advances redefining arrhythmia prevention and treatment, bridging innovative research with clinical practice. Topics of interest include new approaches to conduction system pacing and defibrillation, optimization of device implantation, physiological pacing for heart failure prevention, and arrhythmia detection through artificial intelligence.

By gathering cutting-edge research, clinical experience, and technological insights, this Special Issue will offer a forward-looking perspective on how next-generation pacing and defibrillation strategies are revolutionizing the management of arrhythmic disorders and improving patient outcomes.

Dr. Amato Santoro
Dr. Alberto Palazzuoli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac resynchronization therapy
  • conduction system pacing
  • left bundle branch area pacing
  • S-ICD
  • EV-ICD

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Published Papers (1 paper)

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Research

20 pages, 1405 KB  
Article
Predictors and Prognostic Significance of Appropriate Implantable Cardioverter-Defibrillator Therapy in Primary Prevention Patients with Ischemic Cardiomyopathy
by Mateusz Kuśmierz, Jakub Mercik, Marek Śledziona, Barbara Brzezińska, Maria Łoboz-Rudnicka, Bogusława Ołpińska, Krzysztof Dudek, Rafał Wyderka, Krystyna Łoboz-Grudzień and Joanna Jaroch
J. Clin. Med. 2026, 15(3), 1033; https://doi.org/10.3390/jcm15031033 - 28 Jan 2026
Viewed by 399
Abstract
Background: In the population of patients with ischemic cardiomyopathy (IC) and reduced left ventricular ejection fraction, the benefits of prophylactic implantable cardioverter-defibrillator (ICD) therapy are not uniform. Identifying predictors of ventricular arrhythmias to estimate the risk of appropriate therapy is crucial. Methods: Patients [...] Read more.
Background: In the population of patients with ischemic cardiomyopathy (IC) and reduced left ventricular ejection fraction, the benefits of prophylactic implantable cardioverter-defibrillator (ICD) therapy are not uniform. Identifying predictors of ventricular arrhythmias to estimate the risk of appropriate therapy is crucial. Methods: Patients with IC and an ICD for primary prevention implanted between 2006 and 2019 were retrospectively analyzed for appropriate therapy (ATh). The primary objective was to assess predictors of ATh development. The secondary objective was to assess the impact of ATh on survival. Results: Overall, 260 patients (age 67.3 ± 9.4 years, 15.4% female) were analyzed with a follow-up of 4.47 ± 3.02 years. ATh occurred in 79 patients (30.4% of the study group). Independent risk factors for ATh were as follows: non-sustained ventricular tachyarrhythmias (nsVTs) detected before ICD implantation, extensive area of ischemic left ventricular damage on echocardiographic assessment, left ventricular end-diastolic dimension (LVEDd) ≥ 68 mm, history of coronary artery bypass grafting (CABG), and presence of chronic total occlusion (CTO). A multiparameter logit model was created to estimate the probability of ATh. Patients with a score ≥ 0.6 had more than a six-fold higher risk of developing ATh compared with patients with a score < 0.6. Patients after ATh had significantly lower survival compared to patients without intervention (HR 1.69, p = 0.008). Conclusions: Patients with the independent risk factors listed above are at higher risk for ATh. A multiparameter logit model based on these risk factors is effective in estimating the risk of ATh. The occurrence of ATh was associated with a significantly higher risk of all-cause mortality. Full article
(This article belongs to the Special Issue Revolutionizing Arrhythmia Therapy: Novel Approaches in Pacing and Defibrillation)
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