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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Esophageal and Upper Gastrointestinal Surgery: Clinical Advances and Practical Updates
edited by and Peter Grimminger
submission deadline 15 Sep 2026 | 1 articles | Viewed by 907 | Submission Open
Keywords: esophageal cancer; gastric cancer; upper GI surgery; surgical oncology; benign upper GI surgery; surgical innovation; surgical outcomes; surgical guidelines; robotic surgery; minimally invasive surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Cardiovascular Disease in MASLD: New Advances in Therapeutic Targets
edited by
submission deadline 15 Sep 2026 | 1 articles | Viewed by 877 | Submission Open
Keywords: MASLD; cardiovascular disease (CVD); metabolic dysfunction; steatotic liver disease; insulin resistance; dyslipidemia; atherosclerosis; inflammation; GLP-1 receptor agonists; SGLT2 inhibitors; lipid-lowering therapies; cardiometabolic risk; clinical trials; therapeutic targets
(This special issue belongs to the Section Cardiovascular Medicine)
Cardiac Arrest: Appropriate Prognostication and Therapeutic Options
edited by and Jin-hong Min
submission deadline 15 Sep 2026 | 1 articles | Viewed by 745 | Submission Open
Keywords: cardiac arrest; prognosis; hypothermia, induced; resuscitation; magnetic resonance imaging; electroencephalog-raphy; blood pressure; hypoxia-ischemia, brain; extracorporeal membrane oxygenation
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Endoscopic Techniques for Gastrointestinal Diseases
edited by Alberto Tringali
submission deadline 15 Sep 2026 | 1 articles | Viewed by 569 | Submission Open
Keywords: hepatobiliary disease; pancreatic disease; ERCP; interventional EUS; cholangiopancreatoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Pulmonary Arterial Hypertension: Emerging Therapies and Clinical Outcomes
edited by Namita Sood
submission deadline 15 Sep 2026 | Viewed by 367 | Submission Open
Keywords: pulmonary arterial hypertension (PAH); PAH therapy; emerging treatments; sotatercept; inhaled therapy; targeted pharmacotherapy; combination therapy; therapeutic efficacy; pulmonary vascular imaging
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Endodontics
edited by
submission deadline 15 Sep 2026 | Viewed by 342 | Submission Open
Keywords: endodontics; vital pulp therapy; minimally invasive endodontics; clinical endodontic techniques; bioactive sealers
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
State of the Art of Lung Surgery: Modern Horizons in Lung Cancer Treatment
edited by and Edouard Sage
submission deadline 15 Sep 2026 | Viewed by 316 | Submission Open
Keywords: lung-cancer-surgery; thoracic oncology; RATS; VATS; induction therapy; neoadjuvant-immunotherapy; non-intubated thoracic surgery; NITS; segmentectomy; lung-sparing surgery; 3D-reconstruction
(This special issue belongs to the Section General Surgery)
Recent Clinical Updates on Vascular and Endovascular Surgery submission deadline 15 Sep 2026 | Viewed by 306 | Submission Open
Keywords: vascular surgery; endovascular surgery; aortic disease; abdominal aortic aneurysm; peripheral arterial disease; chronic venous disease; endovascular repair; open vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Innovations and Advancements in Spine Surgery
edited by Mitchell K. Ng
submission deadline 15 Sep 2026 | Viewed by 286 | Submission Open
Keywords: spine surgery; minimally invasive spine surgery; robotic-assisted spine surgery; spinal navigation; endoscopic spine surgery; spinal implant; biologics and regenerative therapies; perioperative optimization; patient-reported outcomes; value-based spine care; surgical innovation
(This special issue belongs to the Section Orthopedics)
Cardiac Imaging in the Clinical Management of Heart Failure
edited by Maria Concetta Pastore
submission deadline 15 Sep 2026 | Viewed by 274 | Submission Open
Keywords: heart failure; cardiac imaging; echocardiography; cardiac magnetic resonance; computed tomography; nuclear imaging
(This special issue belongs to the Section Cardiology)
New Insights into Acute Care and Emergency Surgery: 2nd Edition
edited by Jacob Chen and Avi Benov
submission deadline 15 Sep 2026 | Viewed by 255 | Submission Open
Keywords: trauma surgery; emergency surgery; acute care; anesthesia; ICU
(This special issue belongs to the Section General Surgery)
Innovations in Advanced Heart Failure Detection and Management
edited by Vinh Q. Chau and Nikhil Narang
submission deadline 15 Sep 2026 | Viewed by 231 | Submission Open
Keywords: advanced heart failure; systolic heart failure; mechanical circulatory support; left ventricular assist device; heart transplantation outcomes
(This special issue belongs to the Section Cardiology)
Application of Physiotherapy in Clinical Rehabilitation
edited by
submission deadline 17 Sep 2026 | 1 articles | Viewed by 863 | Submission Open
Keywords: therapeutic exercise; neurological rehabilitation; musculoskeletal physiotherapy; cardiopulmonary rehabilitation; intensive care unit (ICU) rehabilitation; gait and balance; pediatric and geriatric physical therapy; sports physical therapy; rehabilitation technology
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advances in Kidney Transplantation submission deadline 18 Sep 2026 | 6 articles | Viewed by 8689 | Submission Open
Keywords: kidney transplantation; immunosuppression; graft survival; donor risk assessment; post-transplant management; rejection and tolerance; precision medicine in transplantation
(This special issue belongs to the Section Nephrology & Urology)
Clinical Perspectives in Pediatric Surgery: From Neonatal Procedures to Adolescent Care submission deadline 18 Sep 2026 | 1 articles | Viewed by 821 | Submission Open
Keywords: mini invasive surgery; transitional care of rare diseases; newborn surgery; long-term follow up; congenital malformations
(This special issue belongs to the Section Clinical Pediatrics)
Current Trends in Implant Dentistry
edited by Marco Toia
submission deadline 20 Sep 2026 | 9 articles | Viewed by 29524 | Submission Open
Keywords: digital implant planning; osseointegration; guided surgery (static and dynamic); bone regeneration; zygomatic and pterygoid implants; 3D previsualization; craniofacial analysis; peri-implant diseases; immediate loading
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advancements in Spine Surgery: Best Practices and Outcomes
edited by
submission deadline 20 Sep 2026 | 12 articles | Viewed by 26137 | Submission Open
Keywords: adult spinal deformity; scoliosis; frailty; biological age; big data analysis
(This special issue belongs to the Section Orthopedics)
Applied Cardiorespiratory Physiology in Critical Care Medicine
edited by and Paraskevi Tselioti
submission deadline 20 Sep 2026 | 5 articles | Viewed by 19411 | Submission Open
Keywords: applied physiology; critical care medicine; cardiovascular physiology; respiratory physiology
(This special issue belongs to the Section Anesthesiology)
Acute Pancreatitis and Its Complications: Current Diagnostics and Management
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 19376 | Submission Open
Keywords: acute pancreatitis; pancreas; pancreatic and peripancreatic necrosis; management; less invasive percutaneous radiological and endoscopic approaches
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Skin Disease and Inflammation
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 16473 | Submission Open
Keywords: inflammatory skin diseases; inflammation mechanisms; skin microbiome; psoriasis; eczema; rosacea
(This special issue belongs to the Section Dermatology)
Coronary Artery Disease: Diagnosis, Treatment Challenges, and Emerging Therapy submission deadline 20 Sep 2026 | 5 articles | Viewed by 12330 | Submission Open
Keywords: coronary artery disease; percutaneous coronary intervention; cardiovascular disease; emerging therapies; treatment challenges; biomarkers; interventional cardiology
(This special issue belongs to the Section Cardiology)
Clinical Advances in Musculoskeletal Disorders: 2nd Edition
edited by and Sushrut Babhulkar
submission deadline 20 Sep 2026 | 7 articles | Viewed by 11903 | Submission Open
Keywords: musculoskeletal disorders; disability; pain; inflammation; arthritis
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Clinical Exercise for Health
edited by and Joana Ribeiro
submission deadline 20 Sep 2026 | 7 articles | Viewed by 11702 | Submission Open
Keywords: clinical exercise science; physical activity; chronic disease prevention; biomechanics; healthy aging; physiology
(This special issue belongs to the Section Sports Medicine)
Current Challenges and New Perspectives in Liver Transplantation
edited by and
submission deadline 20 Sep 2026 | 9 articles | Viewed by 9808 | Submission Open
Keywords: liver transplantation; graft survival; immunosuppression; organ allocation; hepatocellular carcinoma; MASLD; donor shortage; transplant outcomes; innovation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Perspectives on the Diagnosis and Treatment of Cardiomyopathies
edited by Luca Arcari
submission deadline 20 Sep 2026 | 5 articles | Viewed by 8766 | Submission Open
Keywords: cardiomyopathies; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac amyloidosis; arrhythmogenic right ventricular cardiomyopathy; non-dilated left ventricular cardiomyopathy; cardiac magnetic resonance imaging; computed tomography; echocardiography; nuclear imaging
(This special issue belongs to the Section Cardiology)
Thoracic Surgery: State of the Art and Future Directions
edited by and
submission deadline 20 Sep 2026 | 6 articles | Viewed by 8647 | Submission Open
Keywords: thoracic surgery; lung surgery; lung cancer; rib fractures; lung disease; pectus excavatum
(This special issue belongs to the Section Respiratory Medicine)
Cognitive Impairment, Dementia and Depression in Older Adults
edited by Seong Jae Kim and Ilhan Choo
submission deadline 20 Sep 2026 | 3 articles | Viewed by 6665 | Submission Open
Keywords: cognitive impairment; dementia; depression; Parkinson’s disease; artificial intelligence (AI); predictive modeling
(This special issue belongs to the Section Geriatric Medicine)
Advances in Minimally Invasive Gynecologic Surgery: Optimizing Outcomes and Perioperative Strategies
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 5348 | Submission Open
Keywords: minimally invasive gynecologic surgery; MIGS; laparoscopy; robotic surgery; endometrial cancer; endometriosis
(This special issue belongs to the Section Obstetrics & Gynecology)
Maxillomandibular Growth, Reconstruction and Rehabilitation: Orthodontic, Prosthodontic and Surgical Interventions from Childhood to Adulthood
edited by Kamila Chęcińska and
submission deadline 20 Sep 2026 | 5 articles | Viewed by 5238 | Submission Open
Keywords: maxillomandibular growth; orthodontics; prosthodontics; surgical interventions; childhood; adulthood; reconstruction; rehabilitation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances in Systemic Lupus Erythematosus (SLE)
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 5127 | Submission Open
Keywords: systemic lupus erythematosus; autoantibodies and biomarkers; lupus nephritis; new and novel treatments; targeted treatment or precision medicine; quality of life
(This special issue belongs to the Section Immunology & Rheumatology)
Modern Gynecological Surgery: Clinical Updates and Perspectives
edited by , and Maya Sophie de Wilde
submission deadline 20 Sep 2026 | 4 articles | Viewed by 4936 | Submission Open
Keywords: gynecological diseases; gynecological surgery; surgical options; individual treatment; women’s health care
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Antithrombotic Therapy in Cardiovascular Medicine
edited by Daniele Giacoppo and Antonio Greco
submission deadline 20 Sep 2026 | 6 articles | Viewed by 4212 | Submission Open
Keywords: anticoagulant; antiplatelet; antithrombotic therapy; cardiovascular pharmacotherapy; coronary artery disease; in-flammation; lipid-lowering drugs; lipid metabolism; residual cardiovascular risk; thrombosis
(This special issue belongs to the Section Cardiovascular Medicine)
New Insights into the Management of Psoriasis and Immune-Mediated Dermatoses
edited by Federico Bardazzi and Riccardo Balestri
submission deadline 20 Sep 2026 | 6 articles | Viewed by 3995 | Submission Open
Keywords: psoriasis; immune-mediated inflammatory diseases; biologic therapy; small-molecule drugs; personalized treatment; real-world evidence; comorbidities; patient-centered care
(This special issue belongs to the Section Dermatology)
Liquid Biopsies in Oral Cancer: Advances and New Perspectives submission deadline 20 Sep 2026 | 1 articles | Viewed by 3652 | Submission Open
Keywords: oral cancer; oral potentially malignant disorders; liquid biopsies; saliva and blood biomarkers; circulating tumor cells (CTCs); cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA); cell-free RNA (cfRNA); extracellular vesicles (EVs); genetic and epigenetic biomarkers; early detection; prognosis and therapy response prediction; precision medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Innovations and Advances in Primary Care and Family Medicine
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 3646 | Submission Open
Keywords: primary care; family medicine; integrated care; chronic disease management; multimorbidity; mental health; digital health; artificial intelligence; population health management; implementation research; health services research; interdisciplinary collaboration; evidence-based practice
(This special issue belongs to the Section Epidemiology & Public Health)
Contemporary Oral and Maxillofacial Surgery: Expert Consensus and Best Practices
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 3607 | Submission Open
Keywords: facial trauma; TMJ disorders; implant and sinus surgery; sleep apnea; cosmetic and reconstructive surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Residual Risk in High-Risk Patients Undergoing Percutaneous Coronary Intervention submission deadline 20 Sep 2026 | 1 articles | Viewed by 3482 | Submission Open
Keywords: cardiology; precision medicine; residual risk; acute coronary syndrome; percutaneous coronary intervention; PCI
(This special issue belongs to the Section Cardiology)
Minimally Invasive and Endoscopic Neurosurgery
edited by , Vassilios Tsitouras and Stylianos Kapetanakis
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3461 | Submission Open
Keywords: traumatic brain injury; neuro-oncology; hydrocephalus and cerebrospinal fluid disorders; neuroendoscopy; endo-scopic neurosurgery; skull base surgery; vascular neurosurgery; functional neurosurgery; pediatric neurosurgey; minimally invasive spine surgery; endoscopic spine surgery; spine endoscopy
(This special issue belongs to the Section Clinical Neurology)
Bladder Cancer: Diagnosis and Treatments
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3423 | Submission Open
Keywords: bladder cancer; urothelial cancer; radical cystectomy; targeted therapy; immunotherapy; non-muscle -invasive; muscle-invasive; chemotherapy
(This special issue belongs to the Section Nephrology & Urology)
Postpartum Depression: What Happened to My Wife? submission deadline 20 Sep 2026 | 3 articles | Viewed by 3366 | Submission Open
Keywords: postpartum depression; clinical and health psychology; perinatal trauma; clinical and health psychology; mental health and quality of life
(This special issue belongs to the Section Mental Health)
Innovations in Emergency and Critical Care Medicine
edited by Yoshiaki Iwashita
submission deadline 20 Sep 2026 | 3 articles | Viewed by 3361 | Submission Open
Keywords: emergency; artificial intelligence; Tele-ICU; point of care; electrical impedance tomography
(This special issue belongs to the Section Intensive Care)
Clinical Management in Chronic Pain: Innovations, Integration, and Interventions
edited by Giuliano Lo Bianco, Silvia Natoli and Sean Li
submission deadline 20 Sep 2026 | 3 articles | Viewed by 3092 | Submission Open
Keywords: chronic pain; clinical management; interventional pain medicine; spinal cord stimulation; regenerative medicine; diagnostic strategies; pain semeiotics; multidisciplinary approaches; personalized medicine; pain assessment; neuromodulation; evidence-based pain therapy
(This special issue belongs to the Section Clinical Neurology)
Personalized Treatments for Patients with Acute Lung Injury
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3080 | Submission Open
Keywords: personalized; acute lung injury; acute respiratory distress syndrome (ARDS); ventilator-induced lung injury (VILI); pharmacotherapy; fluid resuscitation; phenotypes; mesenchymal stem cells; nano-systems; exosomes; biomarkers; computational models
(This special issue belongs to the Section Respiratory Medicine)
Advancements and Challenges in Retina Surgery: Second Edition
edited by Joaquín Marticorena and
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3066 | Submission Open
Keywords: retina; vitreoretinal diseases; vitreotomes; optical coherence tomography; vitreoretinal surgery
(This special issue belongs to the Section Ophthalmology)
Polycystic Ovary Syndrome (PCOS): From Diagnosis to Personalized and Integrated Treatment
edited by Satu Kuokkanen
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2799 | Submission Open
Keywords: PCOS; integrated treatment model; metabolic abnormalities; mental health; adverse obstetric outcomes
(This special issue belongs to the Section Obstetrics & Gynecology)
Minimally Invasive Surgery: Challenges and Solutions in Clinical Practice
edited by and Alessia Fassari
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2771 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; surgical challenges; clinical practice; surgical training; robotic-assisted surgery; artificial intelligence in surgery; laparoscopic instrumentation; intraoperative complications; surgical innovation; skill enhancement; surgical outcomes
(This special issue belongs to the Section General Surgery)
Clinical Research and Insights in Endometriosis submission deadline 20 Sep 2026 | 2 articles | Viewed by 2675 | Submission Open
Keywords: endometriosis; pelvic pain; infertility; inflammation; minimal access surgery; laparoscopy; hysteroscopy; robotics
(This special issue belongs to the Section Obstetrics & Gynecology)
Bridging Bench, Bedside, and Beyond: Clinical and Translational Strategies for Pregnancy Complications submission deadline 20 Sep 2026 | 3 articles | Viewed by 2672 | Submission Open
Keywords: high-risk pregnancy; cardiovascular complications; cardiometabolic complications; gestational diabetes; pregnancy complications; preeclampsia; hypertension; vascular disorders; endothelial dysfunction; clinical prediction; antenatal diagnosis; personalized treatment
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Emerging Treatment Options in Atrial Fibrillation
edited by Hoang Nhat Pham and Amitoj Singh
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2568 | Submission Open
Keywords: atrial fibrillation; AF ablation; lifestyle intervention; rhythm control; pulsed field ablation; antiarrhythmic drugs; direct oral anticoagulants
(This special issue belongs to the Section Cardiology)
Advances and Challenges in Colorectal Cancer
edited by Vignesh Narasimhan
submission deadline 20 Sep 2026 | 4 articles | Viewed by 2534 | Submission Open
Keywords: anal fistula; advancement flap; ‎ligation of intersphincteric tract; haemorrhoid surgery; pilonidal surgery
(This special issue belongs to the Section Oncology)
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