Polycystic Ovary Syndrome (PCOS): From Diagnosis to Personalized and Integrated Treatment
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".
Deadline for manuscript submissions: 20 September 2026 | Viewed by 737
Special Issue Editor
Special Issue Information
Dear Colleagues,
Polycystic ovary syndrome (PCOS) is a common and heterogeneous reproductive endocrine disorder affecting approximately 10–13% of women worldwide. Clinical diagnosis is primarily a diagnosis of exclusion and is based on the Rotterdam criteria, which require the presence of two of three features: (1) oligo- or amenorrhea, (2) clinical and/or biochemical hyperandrogenism, and (3) polycystic ovarian morphology. The expression and severity of these diagnostic features, as well as their associated comorbidities, vary widely among affected individuals, underscoring the substantial phenotypic heterogeneity of the syndrome.
Beyond menstrual irregularities and endocrine abnormalities, expanding evidence demonstrates that women with PCOS experience a broad spectrum of associated comorbidities, with considerable variability in prevalence and clinical impact. These include metabolic dysfunction, increased risk of cardiovascular disease, obstructive sleep apnea, nonalcoholic fatty liver disease, and mental health and quality-of-life impairments, in addition to anovulatory infertility and adverse obstetric outcomes. Although a subset of women with PCOS exhibit a lean phenotype, obesity frequently coexists with PCOS and appears to have a bidirectional and modifying relationship with the disorder that, even if not strictly causal, substantially influences its clinical and metabolic manifestations.
Taken together, this growing recognition of PCOS as a multisystem and lifelong condition highlights the limitations of a one-size-fits-all management approach. Effective care increasingly requires integrated and personalized strategies that address individual reproductive, metabolic, and mental health needs across the life span.
In this Special Issue, we invite authors to submit manuscripts reporting translational and clinical research on advances in PCOS diagnosis; the role of nutraceuticals; comorbidities and obesity; and evolving personalized and integrated approaches to PCOS care.
Dr. Satu Kuokkanen
Guest Editor
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Keywords
- PCOS
- integrated treatment model
- metabolic abnormalities
- mental health
- adverse obstetric outcomes
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