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Acute Ischemic Heart Disease: Risk Factors, Diagnosis, Management and Prognosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 673

Special Issue Editor


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Guest Editor
1. Department of Clinical and Experimental Medicine, Division of Cardiology, Policlinico G Martino, University of Messina, 98125 Messina, Italy
2. Division of Cardiology, IRCCS Hospital Galeazzi-Sant’Ambrogio, 20157 Milan, Italy
Interests: STEMI; platelet and antiplatelet therapies; coronary stenting; genetic polymorphisms; atherosclerosis
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Special Issue Information

Dear Colleagues,

Coronary artery disease and acute myocardial infarction are leading causes of mortality across the world. In the last few years, many efforts have been made to improve the treatment and survival of acute cardiac patients. The establishment of well-run networks has sped up the diagnosis and treatment of these high-risk patients, facilitating the rapid recognition and treatment of acute complications and application of percutaneous and mechanical reperfusion to the vast majority of acute ischemic patients. Several advances in adjunctive mechanical devices and pharmacological therapies have enabled the development of tailored therapies and further improved patient outcomes. However, they remain unsatisfactory in some high-risk subgroups, such as those with cardiogenic shock and diabetes.

Therefore, we seek manuscripts covering recent advances in the diagnosis, management, and prognostic stratification of patients suffering from acute cardiac and coronary artery disease, including original clinical studies and reviews.

Prof. Dr. Giuseppe De Luca
Guest Editor

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Keywords

  • acute coronary syndromes
  • STEMI
  • cardiogenic shock
  • primary angioplasty
  • antiplatelet therapies
  • anticoagulation
  • stent thrombosis
  • mechanical support devices
  • acute heart failure

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Published Papers (1 paper)

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Review

14 pages, 694 KB  
Review
Myocardial Infarction as the First Clinical Manifestation of Coronary Artery Disease: A Scoping Review
by Maya D’Angelo, Angeliki Psycharis, Nicolo Piazza, Giuseppe De Luca and Elvin Kedhi
J. Clin. Med. 2026, 15(7), 2603; https://doi.org/10.3390/jcm15072603 - 29 Mar 2026
Viewed by 386
Abstract
Background/Objectives: Acute myocardial infarction (AMI) remains a leading cause of death worldwide and sometimes occurs as the inaugural presentation of CAD. Studies have been heterogeneous in reporting what proportion this population represents; therefore, we sought to review the evidence of myocardial infarction [...] Read more.
Background/Objectives: Acute myocardial infarction (AMI) remains a leading cause of death worldwide and sometimes occurs as the inaugural presentation of CAD. Studies have been heterogeneous in reporting what proportion this population represents; therefore, we sought to review the evidence of myocardial infarction as the initial manifestation of CAD. Methods: We conducted a scoping review of 25 studies (1979–2021) assessing the prevalence, risk factors, and outcomes of patients who experience AMI as the first clinical manifestation of CAD. Results: Across studies, most found that half of AMI patients present with no prior angina or CAD diagnosis. These patients tend to be younger and have fewer traditional risk factors. Sex differences were inconsistently reported, though some studies suggest that women may be more likely to present with unheralded AMI. Diabetes and hypertension were interestingly more common in patients with known CAD. Patients with unheralded AMI demonstrate a larger infarct size and may have a higher likelihood of adverse cardiovascular events compared to those with known CAD. Conclusions: Our findings highlight a critical gap in the current risk models of CAD evaluation, which are often symptom-based and focused on detecting ischemia, thus failing to detect a significant proportion that present with AMI as their initial manifestation of CAD. Full article
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