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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Shoulder and Elbow Surgery: Clinical Updates and Digital Transformation submission deadline 20 Dec 2026 | Viewed by 221 | Submission Open
Keywords: shoulder surgery; elbow surgery; digitalization; patient pathway; clinical decision support systems; artificial intelligence; machine learning; radiological imaging; 3D planning; navigation; robotics; augmented reality; PROMs; wearables; big data; registries; outcome prediction; digital twins; large language models (LLMs); digital health; personalized medicine
(This special issue belongs to the Section Orthopedics)
Transforming the Diagnosis and Management of Retinal Diseases: Integrating Imaging, Modeling, and Digital Innovation submission deadline 20 Dec 2026 | Viewed by 213 | Submission Open
Keywords: retinal diseases; choroidal diseases; multimodal imaging; optical coherence tomography; OCT angiography; adaptive optics; artificial intelligence; imaging biomarkers; predictive modelling; precision medicine; digital ophthalmology; clinical management
(This special issue belongs to the Section Ophthalmology)
Clinical Updates in Treating Orthopaedic Deformities of the Foot submission deadline 20 Dec 2026 | Viewed by 213 | Submission Open
Keywords: foot deformity; hallux valgus; progressive collapsing foot deformities; ankle arthroplasty; minimally invasive surgery; diabetic foot; trauma; reconstructive surgery; clinical outcomes
(This special issue belongs to the Section Orthopedics)
Modern Diagnosis and Management of Coronary Artery Disease
edited by
submission deadline 20 Dec 2026 | Viewed by 206 | Submission Open
Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis
(This special issue belongs to the Section Cardiology)
Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions—2nd Edition
edited by Mauro Zaccarelli and
submission deadline 20 Dec 2026 | Viewed by 201 | Submission Open
Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex; doxycicline prophylaxis; gonococcal resistance
(This special issue belongs to the Section Infectious Diseases)
Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions: 2nd Edition
edited by Roberto Scacciavillani and Gemma Pelargonio
submission deadline 20 Dec 2026 | Viewed by 199 | Submission Open
Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing
(This special issue belongs to the Section Cardiology)
Rethinking Renal Pathways: Recent Advances in Diagnosis, Vascular Access, and Targeted Therapy in Chronic Kidney Disease (CKD)
edited by Alina Ramona Potra, Ina Maria Kacsò and
submission deadline 20 Dec 2026 | Viewed by 198 | Submission Open
Keywords: chronic kidney disease; biomarkers in kidney disease; precision nephrology; artificial intelligence in nephrology; vascular access for dialysis; targeted therapies in CKD; malnutrition and protein-energy wasting in CKD; renal fibrosis and disease progression; translational nephrology research
(This special issue belongs to the Section Nephrology & Urology)
Cutting-Edge Advances in Valvular Heart Diseases: Novel Repair & Replacement Strategies submission deadline 20 Dec 2026 | Viewed by 184 | Submission Open
Keywords: valvular heart disease; echocardiography; transcatheter edge-to-edge repair; transcatheter aortic valve implantation; transcatheter mitral valve replacement; transcatheter tricuspid valve replacement; artificial intelligence; cardiac imaging; valvular heart surgery
(This special issue belongs to the Section Cardiology)
Hearing Rehabilitation Through Implantable Devices and Cochlear Implants
edited by Mario Sanna
submission deadline 20 Dec 2026 | Viewed by 178 | Submission Open
Keywords: cochlear implant; implantable devices; hearing rehabilitation; otoneurosurgery; middle ear surgery; otoneurological rehabilitation; schwannoma; cochlear ossification; difficult cases
(This special issue belongs to the Section Otolaryngology)
Laser Techniques in Prostate Treatment Innovations
edited by Matteo Vittori and Valerio Iacovelli
submission deadline 20 Dec 2026 | Viewed by 177 | Submission Open
Keywords: benign prostatic obstruction; laser prostate surgery; endoscopic enucleation; minimally invasive urology; surgical innovation
(This special issue belongs to the Section Nephrology & Urology)
Innovative Therapeutic Strategies for Retinal Diseases
edited by Akihiro Ohira
submission deadline 20 Dec 2026 | Viewed by 177 | Submission Open
Keywords: retinal diseases; innovative therapies; clinical research; drug delivery; imaging biomarkers; real-world evidence; clinical application
(This special issue belongs to the Section Ophthalmology)
Clinical Challenges in Abdominal Infections Management: Dynamic Source Control and Adaptive Antibiotic Therapy submission deadline 20 Dec 2026 | Viewed by 170 | Submission Open
Keywords: abdominal infections; source control failure; re-operation; antibiotic de-escalation; short-course antibiotic therapy; procalcitonin; multidrug-resistant organisms; enterococci; candida; empirical therapy
(This special issue belongs to the Section Infectious Diseases)
Prostate Cancer: Clinical Progress, Challenges and Opportunities
edited by Giulio Francesco Reale, and
submission deadline 20 Dec 2026 | Viewed by 140 | Submission Open
Keywords: prostate cancer; robotic surgery; Fusion Biopsy; PET-PSMA; radical prostatectomy; nerve sparing surgery; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Robotic Surgery in Urology: Current Advances and Future Perspectives
edited by
submission deadline 22 Dec 2026 | 1 articles | Viewed by 773 | Submission Open
Keywords: augmented reality; augmented sensations; artificial intelligence; single-port; reconstructive surgery; oncological surgery; image-guided surgery
(This special issue belongs to the Section Nephrology & Urology)
Biostatistics in Real-World Clinical Research: From Big Data to Clinical Decision-Making
edited by and Chul-Ho Oak
submission deadline 22 Dec 2026 | Viewed by 231 | Submission Open
Keywords: clinical biostatistics; epidemiology; real-world data; population-based cohort; survival analysis; clinical prediction models; prognostic modeling; risk stratification; translational clinical research; quantitative clinical data analysis
(This special issue belongs to the Section Clinical Research Methods)
Managements of Venous Thromboembolism submission deadline 24 Dec 2026 | 6 articles | Viewed by 8485 | Submission Open
Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine
(This special issue belongs to the Section Vascular Medicine)
Recent Research Progress in Pediatric Orthopedic Surgery
edited by and Madeleine Willegger
submission deadline 25 Dec 2026 | 7 articles | Viewed by 17456 | Submission Open
Keywords: pediatric orthopedics; deformity correction; pediatric hip; pediatric trauma; basic research in pediatric orthopedics; clubfoot; pediatric foot and ankle deformities; pediatric hand
(This special issue belongs to the Section Clinical Pediatrics)
Oral and Maxillofacial Surgery: Current Advances and Future Directions
edited by Iwona Niedzielska
submission deadline 25 Dec 2026 | 5 articles | Viewed by 15542 | Submission Open
Keywords: oral and maxillofacial surgery; reconstructive surgery; periodontitis; dental implants; maxillofacial deformities
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Interstitial Lung Diseases: New Treatments and Future Directions
edited by Justyna Fijołek
submission deadline 25 Dec 2026 | 4 articles | Viewed by 12092 | Submission Open
Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Radiation Therapy for Cancers submission deadline 25 Dec 2026 | 7 articles | Viewed by 10056 | Submission Open
Keywords: radiation oncology; radiotherapy; cancer radiotherapy; cancer radiation therapy; radiobiology; predictive and prognostic biomarkers; cancer treatment; heavy ions radiation oncology; protontherapy; cancer biolology
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Anesthesia and Intensive Care in Orthopedic and Trauma Surgery
edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi
submission deadline 25 Dec 2026 | 2 articles | Viewed by 8219 | Submission Open
Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium
(This special issue belongs to the Section Intensive Care)
New Insights into Skin Tumors: From Pathogenesis to Therapy
edited by Loredana Ungureanu and Simona C. Şenilǎ
submission deadline 25 Dec 2026 | 4 articles | Viewed by 7757 | Submission Open
Keywords: skin tumors; pathogenesis; diagnosis; personalized medicine; therapeutic strategies; dermato-oncology
(This special issue belongs to the Section Dermatology)
Advances and Innovations in Hand Surgery
edited by , Jason Wink and Anthony Archual
submission deadline 25 Dec 2026 | 5 articles | Viewed by 5766 | Submission Open
Keywords: hand surgery; peripheral nerve surgery; shared decision making; microsurgery; arthritis; compression neuropathy; carpal tunnel; cubital tunnel
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders
edited by Natalia Motas and Veronica Manolache
submission deadline 25 Dec 2026 | 3 articles | Viewed by 4161 | Submission Open
Keywords: lung cancer; minimally invasive thoracic surgery (MITS); video-assisted thoracoscopic surgery (VATS); robot-assisted thoracic surgery (RATS); interventional pneumology; bronchoscopy; endobronchial ultrasound (EBUS); artificial intelligence (AI); lung nodule
(This special issue belongs to the Section Respiratory Medicine)
Current and Emerging Treatment Options in Colorectal Cancer
edited by Michael Osseis
submission deadline 25 Dec 2026 | 4 articles | Viewed by 3849 | Submission Open
Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment
edited by Massimiliano Mariani
submission deadline 25 Dec 2026 | 3 articles | Viewed by 3759 | Submission Open
Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies
(This special issue belongs to the Section Cardiology)
Bariatric Surgery: Current Status and Emerging Clinical Trends
edited by Collin E. M. Brathwaite
submission deadline 25 Dec 2026 | 3 articles | Viewed by 2496 | Submission Open
Keywords: bariatric surgery; metabolic surgery; obesity; GLP-1 receptor agonists; robotic surgery; revisional surgery; weight regain; metabolic mechanisms; enhanced recovery; surgical innovation
(This special issue belongs to the Section General Surgery)
Congenital Heart Disease in Adults (ACHD): Diagnosis, Therapy, and Clinical Management
edited by Mirosław Kowalski
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1359 | Submission Open
Keywords: congenital cardiac defect in adults; right ventricular failure; strain echocardiography; ventricular mechanics; cardiac resynchronizing therapy (CRT); Fontan operation; protein-losing enteropathy (PLE)
(This special issue belongs to the Section Cardiology)
Pelvic Organ Prolapse: Current Progress and Clinical Challenges, 2nd Edition
edited by and Cosimo De Nunzio
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1317 | Submission Open
Keywords: pelvic organ prolapse (POP); postmenopausal; urinary dysfunction; minimally invasive surgery; laparoscopic sur-gery; robotic surgery; surgical mesh
(This special issue belongs to the Section Obstetrics & Gynecology)
Multidisciplinary Care in Severe Traumatic Brain Injury Across the Continuum of Care: Acute, Rehabilitative, and Chronic Management
edited by Ryan Martin, Davin Quinn and Nicholas Race
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1257 | Submission Open
Keywords: severe traumatic brain injury; multidisciplinary; rehabilitation; advance practice providers; ancillary health; therapy; neuropsychology; nutrition
(This special issue belongs to the Section Brain Injury)
New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice
edited by Mattia Algeri
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1044 | Submission Open
Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship
(This special issue belongs to the Section Hematology)
Advances in New Clinical Perspectives on Chronic Kidney Disease submission deadline 25 Dec 2026 | 1 articles | Viewed by 1039 | Submission Open
Keywords: chronic kidney disease; kidney injury; kidney perfusion; glomerulonephritis; cardio-kidney-metabolic syndrome; systemic vasculitis; sarcopenia; nephroprotection
(This special issue belongs to the Section Nephrology & Urology)
Movement Disorders: Current Diagnostics, Management and Future Perspectives
edited by and Marianthi A. Arnaoutoglou
submission deadline 25 Dec 2026 | 1 articles | Viewed by 853 | Submission Open
Keywords: neuroimaging; neuromodulation; cell and gene therapy; digital biomarkers; deep learning; artificial intelligence; movement disorders; hypokinetic; hyperkinetic; immune-mediated movement disorders; neurodegenerative movement disorders
(This special issue belongs to the Section Clinical Neurology)
Treatment of Atopic Dermatitis, 2nd Edition
edited by and Ricardo Ruíz-Villaverde
submission deadline 25 Dec 2026 | 1 articles | Viewed by 801 | Submission Open
Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment
(This special issue belongs to the Section Dermatology)
Innovations in ENT Surgical Procedures
edited by , Giuseppe Fancello and
submission deadline 25 Dec 2026 | 1 articles | Viewed by 598 | Submission Open
Keywords: endoscopic sinus surgery; ear surgery; transoral robotic surgery; image-guided navigation; ENT minimally invasive techniques; ENT surgical innovation
(This special issue belongs to the Section Otolaryngology)
Clinical Perspectives in Acne, Rosacea, and Hidradenitis Suppurativa
edited by Marta Szepietowska and Lukasz Matusiak
submission deadline 25 Dec 2026 | 1 articles | Viewed by 533 | Submission Open
Keywords: acne; acneiform eruption; rosacea; hidradenitis suppurativa; clinical perspective; comorbidities; novel pharmacological options; procedural interventions
(This special issue belongs to the Section Dermatology)
Robotic Cardiac Surgery–State of the Art
edited by Borut Geršak, Robert Phillip Gallegos and Michael E.K. Ibrahim
submission deadline 25 Dec 2026 | 1 articles | Viewed by 485 | Submission Open
Keywords: robotic cardiac surgery; minimally invasive cardiac surgery; cardiac robotics; mitral valve surgery; aortic valve surgery; surgical robotics; cardiac surgery training; minimally invasive techniques; robotic technology
(This special issue belongs to the Section Cardiology)
Hepatobiliary and Pancreatic Cancers: Current Solutions and Future Perspectives
edited by and Cătălina Vlăduț
submission deadline 25 Dec 2026 | Viewed by 327 | Submission Open
Keywords: pancreatic neoplasia; pancreatic ductal adenocarcinoma; cholangiocarcinoma; endosonography; ERCP; cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Quantitative Surface Electromyography for Masticatory and Trigemino-Cervical Assessment: Novel Indices, Diagnostic Accuracy, and Clinical Applications
edited by
submission deadline 25 Dec 2026 | Viewed by 276 | Submission Open
Keywords: surface electromyography; sEMG; masticatory system; trigemino-cervical assessment; clinical applications; cervico-craniofacial disorders; temporomandibular disorders; pain assessment; bruxism
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Current Trends in Abdominal Surgery
edited by
submission deadline 25 Dec 2026 | Viewed by 245 | Submission Open
Keywords: abdominal surgery; minimally invasive surgery; robotic surgery; gastrointestinal surgery; artificial intelligence in surgery; enhanced recovery after surgery (ERAS)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Urinary System Dysfunction: Focusing on Neurogenic Lower Urinary Tract Dysfunction and Prostate Diseases
edited by , Marie Aimée Perrouin Verbe and Xavier Biardeau
submission deadline 25 Dec 2026 | Viewed by 220 | Submission Open
Keywords: neurourology; neurogenic bladder; benign prostate hyperplasia; bladder obstruction; lower urinary tract dysfunction; bladder outlet obstruction; prostate cancer; lower urinary tract symptoms
(This special issue belongs to the Section Nephrology & Urology)
Innovations in Valve and Heart Failure Disease
edited by Andrea De Martino and Sandro Sponga
submission deadline 25 Dec 2026 | Viewed by 213 | Submission Open
Keywords: heart failure; aortic diseases; mitral valve; aortic valve; tricuspid valve
(This special issue belongs to the Section Cardiology)
Hepatitis: Clinical Guide to Infection, Complications, and Management
edited by Tarek Saadi and
submission deadline 25 Dec 2026 | Viewed by 212 | Submission Open
Keywords: acute hepatitis; chronic hepatitis; liver inflammation; viral hepatitis; HBV reactivation; immunocompromised host; oncology-associated hepatitis; antiviral therapy; biomarkers; non-invasive fibrosis; HDV; CMV; EBV; HSV; VZV; coinfection
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Sjogren’s Syndrome: Clinical Updates and Perspectives
edited by Caterina Vacchi
submission deadline 25 Dec 2026 | Viewed by 190 | Submission Open
Keywords: Sjogren’s disease; extra-glandular involvement; interstitial lung disease; treatment approach; precision medicine; patient subgrouping; patient-reported outcomes
(This special issue belongs to the Section Immunology & Rheumatology)
Advances in Neo-Adjuvnat Treatment and Tumor Microenvironment for Gastrointestinal Cancers
edited by
submission deadline 25 Dec 2026 | Viewed by 181 | Submission Open
Keywords: tumor microenviroment; chronic imflammation; gastrointestinal tumors; conversion surgery; target tumor chemotherapy; immunocheck point inhibitors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Emerging Trends in Athlete Health: Advanced Monitoring for Injury Prevention and Recovery submission deadline 25 Dec 2026 | Viewed by 146 | Submission Open
Keywords: sport medicine; sports injuries; injury prevention; rehabilitation; athletic performance; return to play; clinical bio-mechanics; sports physiotherapy; wearable technology
(This special issue belongs to the Section Sports Medicine)
Multifactorial Causation and Therapies of Myopia: 2nd Edition submission deadline 26 Dec 2026 | 2 articles | Viewed by 2697 | Submission Open
Keywords: epidemiology; genetics; premyopia; simple and pathological myopia; orthokeratology; lenses for myopia control; blue light and red light; binocular vision and ocular optics; artificial intelligence
(This special issue belongs to the Section Ophthalmology)
Harnessing the Power of Genomic Technologies for Personalized Medicine and Diagnosis
edited by and
submission deadline 27 Dec 2026 | Viewed by 173 | Submission Open
Keywords: personalized medicine; clinical genomics; next-generation sequencing (NGS); epigenomics; microbiome analysis; host–microbiome interactions
(This special issue belongs to the Section Clinical Laboratory Medicine)
From Biology to Bedside: Novel Clinical Strategies in Obesity-Linked Cardiometabolic Disease
edited by Matilda Florentin and
submission deadline 28 Dec 2026 | 2 articles | Viewed by 2112 | Submission Open
Keywords: obesity; cardiometabolic disease; type 2 diabetes; cardiovascular risk; adipose tissue dysfunction; inflammation; biomarkers; precision medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Pediatric Ophthalmology: Current Progress and Future Options submission deadline 30 Dec 2026 | 5 articles | Viewed by 3509 | Submission Open
Keywords: pediatric ophthalmology; genetic eye diseases; gene therapy; genetic counseling; telemedicine; diagnostic tools; blindness in childhood; congenital cataract; visual rehabilitation; myopia control
(This special issue belongs to the Section Ophthalmology)
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