Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions—2nd Edition

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue, ‘Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions—2nd Edition’. This is the second edition; we published seven papers in the first edition. For more details, please visit

https://www.mdpi.com/journal/jcm/special_issues/6K04Q5X5ZK.

In recent years, a growing incidence of sexually transmitted infections (STIs) has been reported worldwide, particularly for syphilis, gonorrhea, and chlamydia, underscoring the continued relevance of these diseases in modern society. The HIV epidemic continues to significantly influence the prevalence of STIs, particularly as a result of the widespread use of PrEP (pre-exposure prophylaxis), which has played a pivotal role in reducing HIV transmission, but may also be reshaping the epidemiology and clinical management of other STIs. Concurrently, the management of HPV-related infections continues to present ongoing challenges, particularly in light of concerns around vaccine coverage, the uneven implementation of vaccination programs, and the recent shift toward single-dose HPV vaccination strategies.

The rising costs of STI management, alongside persistent issues of privacy, stigma, and counseling, further complicate prevention and control efforts. Important barriers to testing and access to care also remain, limiting the effectiveness of public health responses. The interplay between substance use (including chemsex) and STI risk necessitates further investigation, as the evolution of these behaviors continues to shape the dynamics of transmission. Advances in preventive and therapeutic strategies, such as the use of doxycycline as post-exposure prophylaxis, offer new opportunities for managing bacterial STIs, but also raise important concerns regarding antimicrobial stewardship, the emergence of resistance, and long-term effectiveness—particularly in the broader context of increasing antimicrobial resistance in pathogens such as Neisseria gonorrhoeae.

Dr. Mauro Zaccarelli
Dr. Alessandra Latini
Guest Editors

Manuscript Submission Information

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