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Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 15 June 2026 | Viewed by 1300

Special Issue Editor

Dr. Massimiliano Mariani

E-Mail Website
Guest Editor
Fondazione Toscana G. Monasterio, Ospedale del Cuore G. Pasquinucci, 54100 Massa, Italy
Interests: echocardiography; structural heart disease; interventional echocardiography; mitral and tricuspid intervention; cardiac surgery; clinical cardiology; valve therapy

Special Issue Information

Dear Colleagues,

The landscape of valvular heart disease management has evolved significantly in recent years, driven by innovative therapies and advanced diagnostic techniques. In this Special Issue, we delve into the latest clinical updates, focusing on how these advancements are reshaping treatment strategies and improving patient outcomes. One of the most remarkable developments in this field is the increasing personalization of therapeutic approaches. With the advent of novel treatment modalities, healthcare professionals can now tailor interventions to the individual characteristics of each patient, optimizing efficacy while minimizing risks. This shift towards personalized care is transforming the standard of practice in managing valvular heart diseases. Moreover, the integration of cutting-edge imaging technologies has become indispensable in guiding therapeutic decisions. High-resolution imaging not only enhances diagnostic accuracy but also plays a pivotal role in selecting the most appropriate intervention, whether surgical or catheter-based. This diagnostic precision is critical in crafting a strategy that best suits the patient's unique condition.

Additionally, the expansion of minimally invasive techniques has made it possible to treat increasingly frail patients who were previously deemed ineligible for conventional surgery. These less invasive, lower-risk procedures are redefining the risk–benefit ratio, offering new hope to a broader patient demographic.

We invite you to explore this Special Issue as we examine these groundbreaking advancements and their impact on clinical practice.

Dr. Massimiliano Mariani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • valvular heart disease
  • structural heart intervention
  • imaging in valve disease
  • interventional echocardiography
  • minimally invasive cardiac surgery
  • aortic valve intervention
  • tricuspid valve intervention
  • valve intervention in GUCH
  • patient-specific therapy
  • advanced diagnostic techniques
  • gutting-edge cardiac imaging
  • catheter-based interventions
  • innovative cardiac therapies

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Published Papers (2 papers)

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Research

13 pages, 3725 KB  
Article
Trends in Aortic Stenosis Mortality Among Older Adults in the United States from 1999 to 2020
by Muhammad Ahmad, Salman Zahid, Mustafa Shehzad, Dawood Shehzad, Evan Shalen, Hind Rahmouni, Muhammad Raza, Craig Basman, Marian Vandyck-Acquah and Ryan Kaple
J. Clin. Med. 2025, 14(23), 8276; https://doi.org/10.3390/jcm14238276 - 21 Nov 2025
Viewed by 470
Abstract
Background: Aortic stenosis (AS) represents a prevalent valvular condition in older adults, associated with significant morbidity and mortality. The objective of the study was to examine trends in mortality related to AS in the United States (U.S.). Methods: The U.S. CDC WONDER dataset [...] Read more.
Background: Aortic stenosis (AS) represents a prevalent valvular condition in older adults, associated with significant morbidity and mortality. The objective of the study was to examine trends in mortality related to AS in the United States (U.S.). Methods: The U.S. CDC WONDER dataset was analyzed, extracting age-adjusted mortality rates (AAMR) per 100,000 and calculating annual percentage change (APC) through Joinpoint regression. The results were stratified to identify temporal, sex-specific, racial/ethnic, and regional differences. Results: From 1999 to 2020, 267,515 deaths among older adults (>65 years old) were attributed to AS, with the AAMR declining from 28.00 to 23.69. Males had a higher AAMR (30.35) compared to females (27.42), though more deaths occurred in females (164,104 vs. 103,411). Non-Hispanic (NH) Whites exhibited the greatest AAMR (31.61), trailed by NH American Indian/Alaska Native individuals (16.62), whereas NH Asians/Pacific Islanders had the least (11.50). Significant state-wise variations were noted, with AAMRs ranging from 60.55 in Oregon to 17.23 in Mississippi, and 19 states depicting a concerning rise over the study duration. Regionally, the Northeast (32.09) had the highest AAMRs, while the South (23.06) had the lowest. Micropolitan (32.28) and noncore (28.43) areas reported higher AAMRs compared to large central metropolitan areas (24.32). Conclusions: While there is a trend towards decreased mortality due to AS in the U.S., significant disparities based on race, sex, and region persist and may be worsening. The underlying causes of these discrepancies require further investigation, and targeted strategies must be developed to address them effectively. Full article
(This article belongs to the Special Issue Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment)
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16 pages, 1504 KB  
Article
Infective Endocarditis After TAVR—Surgical Challenges and Outcomes
by Andrea Reiter, Julia Schreyer, Melchior Burri, Hendrik Ruge, Markus Krane and Nazan Puluca
J. Clin. Med. 2025, 14(21), 7859; https://doi.org/10.3390/jcm14217859 - 5 Nov 2025
Viewed by 575
Abstract
Background: Infective endocarditis (IE) after transcatheter aortic valve replacement (TAVR) is a severe complication. Surgical explantation of infected transcatheter heart valves (THV) is technically demanding and associated with high mortality. Data on risk factors for perioperative death and long-term outcomes remain limited. Aim: [...] Read more.
Background: Infective endocarditis (IE) after transcatheter aortic valve replacement (TAVR) is a severe complication. Surgical explantation of infected transcatheter heart valves (THV) is technically demanding and associated with high mortality. Data on risk factors for perioperative death and long-term outcomes remain limited. Aim: To identify predictors of mortality in patients undergoing surgical aortic valve replacement (SAVR) for IE after TAVR. Methods: We conducted a case–control study of patients treated with SAVR for IE after TAVR at our center between February 2008 and December 2023. Fifteen patients who died in hospital (cases) were compared with 35 perioperative survivors (controls). Hospital survivors were followed for long-term outcomes. Results: Age, sex, comorbidities (kidney disease, cerebrovascular disease, COPD, diabetes, peripheral artery disease), and anthropometrics were similar between groups. Cases had significantly lower left ventricular function and higher logistic EuroSCORE and STS-PROM before surgery. Causative microorganisms, cross-clamp time, and concomitant procedures did not differ. Postoperative pacemaker implantation, rethoracotomy, stroke, and ICU or hospital stay were comparable, while dialysis was more frequent in cases (44% vs. 25.7%). Median follow-up was 294 days (range 1–3802). Survival was 79.8% at 30 days and 67.4% at 1 year. Of 35 hospital survivors, 29 were discharged home, 6 to rehabilitation/other hospitals; 31 remain alive (1 early, 3 late deaths). Conclusions: SAVR for IE after TAVR carries high early mortality (18.1% at 30 days; 32.6% at 1 year). Higher preoperative risk scores and postoperative dialysis were associated with perioperative death. Long-term survival among hospital survivors is favorable, with most patients regaining independent living. Full article
(This article belongs to the Special Issue Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment)
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