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Advances in New Clinical Perspectives on Chronic Kidney Disease
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Advances in New Clinical Perspectives on Chronic Kidney Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 25 December 2026 | Viewed by 127

Special Issue Editors

Prof. Dr. Arkadiusz Lubas

E-Mail Website
Guest Editor
Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine—National Research Institute, 04-141 Warsaw, Poland
Interests: chronic kidney disease; acute kidney injury; glomerulonephritis; hypertension; cardiovascular risk; kidney perfusion; ultrasonography
Dr. Katarzyna Romejko

E-Mail Website
Guest Editor Assistant
Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine—National Research Institute, 04-141 Warsaw, Poland
Interests: chronic kidney disease; sarcopenia; cardiorenal syndrome; echocardiography

Special Issue Information

Dear Colleagues,

Chronic kidney disease affects over 10% of the world's population. Decreased kidney function leads to a significant increase in cardiovascular risk and all-cause mortality. It is estimated that by 2040, chronic kidney disease will become the fifth leading cause of death worldwide. Therefore, any research that improves detection and diagnostic accuracy, shortens diagnostic time, enhances the quality of monitoring and slows the progression of CKD can contribute to improved health outcomes and reduced mortality.

The aim of this Special Issue is to present new perspectives that have emerged in recent years in the detection, diagnosis, treatment and monitoring of chronic kidney disease, as well as the interaction between the kidney and other organs leading to CKD (cardiorenal, hepatorenal, pulmonary-renal syndrome, gut-kidney axis, etc.). Research articles and reviews are particularly welcome. Areas of research should broadly encompass various etiologies of chronic kidney disease with identified organ interactions, in light of new discoveries and prospects for further research.

We are pleased to invite you to participate in this Special Issue of the Journal of Clinical Medicine on new clinical perspectives on chronic kidney disease. We look forward to receiving your contributions.

Prof. Dr. Arkadiusz Lubas
Guest Editor

Dr. Katarzyna Romejko
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • kidney injury
  • kidney perfusion
  • glomerulonephritis
  • cardio-kidney-metabolic syndrome
  • systemic vasculitis
  • sarcopenia
  • nephroprotection

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Published Papers (1 paper)

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Research

12 pages, 870 KB  
Article
Phosphate Excretion Differentiates the Amount of Nephroprotective Effect of Amino Acid Ketoanalogues Treatment with Low Protein Diet in Chronic Kidney Disease—A Retrospective Single-Center Cohort Study
by Ewelina Jędrych, Arkadiusz Lubas, Julia Bryłowska, Magdalena Mirkowska and Stanisław Niemczyk
J. Clin. Med. 2026, 15(10), 3986; https://doi.org/10.3390/jcm15103986 - 21 May 2026
Abstract
Chronic kidney disease (CKD) affects more than 10% of the world’s population, increasing the risk of cardiovascular disease and mortality. Background: Nephroprotective interventions can reduce the risk of end-stage renal disease, delay the time to dialysis, and prolong life. However, there is [...] Read more.
Chronic kidney disease (CKD) affects more than 10% of the world’s population, increasing the risk of cardiovascular disease and mortality. Background: Nephroprotective interventions can reduce the risk of end-stage renal disease, delay the time to dialysis, and prolong life. However, there is ongoing debate about the effectiveness of combining amino acid ketoanalogues (KAA) with a low-protein diet (LPD) to slow CKD progression. This study aimed to retrospectively analyze kidney function outcomes after a 6-month KAA+LPD regimen in patients with CKD. Methods: The analysis included results from 38 non-dialyzed patients (12 F, 26 M; age 64.0 ± 13.6 years) with stable CKD in stages G4 to G5, who followed LPD with KAA (Ketosteril, Fresenius Kabi) treatment as part of the Polish National Health Fund Ketosteril Drug Program. Results: No significant change in estimated glomerular filtration rate (eGFR) was observed during 6 months of KAA+LPD therapy. However, eGFR increased or decreased in half of the patients (p < 0.001), and this change was associated only with initial protein intake and urinary phosphate excretion. Initial high phosphate excretion was independently associated with an increase in eGFR, and initial phosphaturia > 0.5 g/24 h identified eGFR improvement (sensitivity 84.2%; specificity 57.9%; AUC 0.712; p = 0.018) in CKD patients who started KAA+LPD treatment. Conclusions: Six-month treatment with KAA+LPD may be associated with stabilization of kidney function in patients with CKD stages G4-G5. The individual effect of KAA+LPD on renal function may be related to the initial protein intake level and urinary phosphate excretion. Further studies are needed to validate these findings across larger patient populations with a broader spectrum of symptoms. Full article
(This article belongs to the Special Issue Advances in New Clinical Perspectives on Chronic Kidney Disease)
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