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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Obesity-Related Metabolic and Cardiovascular Disorders

edited by

Lucia Frittitta

and Federica Vinciguerra

submission deadline 20 Jan 2026 | Viewed by 20 | Submission Open

Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Urologic Oncology: 2nd Edition

edited by Saum Ghodoussipour

submission deadline 20 Jan 2026 | Viewed by 17 | Submission Open

Keywords: bladder cancer; kidney cancer; prostate cancer; testis cancer; penile cancer; minimally invasive; cancer treatment

(This special issue belongs to the Section Nephrology & Urology)

Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies

edited by Alessandro Andreis,

Guglielmo Beccuti

and

Angelo Armandi

submission deadline 20 Jan 2026 | Viewed by 13 | Submission Open

Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology

(This special issue belongs to the Section Cardiology)

Macular Diseases: From Diagnosis to Treatment

edited by

Gabriella De Salvo

submission deadline 22 Jan 2026 | Viewed by 37 | Submission Open

Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers

(This special issue belongs to the Section Ophthalmology)

Personalized Radiological and Surgical Strategies for Breast Cancer Treatment

edited by Vlad Alexandru Gata, Maximilian Muntean and

Roxana Pintican

submission deadline 22 Jan 2026 | Viewed by 10 | Submission Open

Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction

(This special issue belongs to the Section General Surgery)

Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond

edited by

Rosalinda Madonna

submission deadline 25 Jan 2026 | 5 articles | Viewed by 9318 | Submission Open

Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors

(This special issue belongs to the Section Cardiovascular Medicine)

Inflammatory Bowel Diseases: Clinical Advances and Emerging Therapies

edited by

Ewa Malecka-Wojciesko

submission deadline 25 Jan 2026 | 2 articles | Viewed by 1010 | Submission Open

Keywords: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’ s disease; gut inflammation; bowel perforation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Ocular Surface Disease: Epidemiology, Diagnosis and Management

edited by

Sandeep K. Dhallu

and

Nicole Carnt

submission deadline 25 Jan 2026 | Viewed by 664 | Submission Open

Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition

edited by

Paul Immanuel Heidekrueger

, Peter Niclas Broer and Denis C. Ehrl

submission deadline 25 Jan 2026 | 1 articles | Viewed by 485 | Submission Open

Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Recent Clinical Advances in Reconstructive Urology and Prosthetic Surgery

edited by Elisa Berdondini and

Esaú Fenández-Pascual

submission deadline 25 Jan 2026 | Viewed by 43 | Submission Open

Keywords: reconstructive urology; penile prosthesis; artificial urinary sphincter; urethral stricture; reconstructive surgery; minimally invasive procedures

(This special issue belongs to the Section Nephrology & Urology)

Further Advances in Electrocardiography, Cardiac Arrhythmias, and Arrhythmogenic Disorders: 2nd Edition

edited by

Paweł T. Matusik

submission deadline 25 Jan 2026 | Viewed by 33 | Submission Open

Keywords: electrocardiography; cardiac arrhythmias; genetics; cardiac pacing; implantable cardioverter defibrillators; cardiac resynchronization therapy; magnetic resonance imaging; catheter ablation; arrhythmogenic disorders; channelopathy; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis

edited by Grigorios Giamouzis

submission deadline 25 Jan 2026 | Viewed by 31 | Submission Open

Keywords: cardiac amyloidosis; transthyretin amyloidosis; hypertrophic cardiomyopathy; cardiac imaging; heart failure

(This special issue belongs to the Section Cardiology)

Clinical Updates in the Use of Artificial Intelligence for Radiology

edited by

Martin R. Prince

submission deadline 25 Jan 2026 | Viewed by 29 | Submission Open

Keywords: deep learning; denoising; calculator; nn-UNet; automation; outcomes; quality control; DICE; Halsdorrf; Jaccard

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Otologic Disorders and Hearing Impairment: From Diagnosis to Rehabilitation

edited by Andrea Albera and Andrea Canale

submission deadline 25 Jan 2026 | Viewed by 27 | Submission Open

Keywords: otology; hearing loss; cochlear implants; middle ear surgery; otitis media; otosclerosis; auditory rehabilitation; ves-tibular disorders; hearing aid; bone-conduction implants

(This special issue belongs to the Section Otolaryngology)

Osteoporotic Fractures of the Pelvis, Hip and Femur: Current Challenges and New Perspectives (2nd Edition)

edited by Andreas Hoch

submission deadline 26 Jan 2026 | Viewed by 29 | Submission Open

Keywords: osteoporosis; fracture management; pelvic fractures; periprosthetic fractures; proximal femoral fractures; non-operative therapies

(This special issue belongs to the Section Orthopedics)

Challenges in Diagnosis and Treatment of Infertility—2nd Edition

edited by Konstantinos A. Zikopoulos

submission deadline 27 Jan 2026 | Viewed by 867 | Submission Open

Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Advances in Scleral Lenses: New Insights in Lens Fitting and Customization

edited by

Daddi Fadel

and

Chelsea Bray

submission deadline 27 Jan 2026 | Viewed by 48 | Submission Open

Keywords: scleral lenses; scleral lens customization; higher-order aberrations; scleral lens optics; corneoscleral profilometry; keratoconus; ocular surface diseases; dry eye; wavefront-guided correction

(This special issue belongs to the Section Ophthalmology)

Heart Valve Surgery: Recent Trends and Future Perspective

edited by Per Nils J.F. Wierup, Johan Sjögren and Nina Hakacova

submission deadline 27 Jan 2026 | Viewed by 35 | Submission Open

Keywords: heart valve; diagnostics; surgery; echocardiography; computer simulation; prediction models

(This special issue belongs to the Section Cardiology)

Current Evidence and Future Directions in Clostridioides difficile Infection Epidemiology, Diagnosis and Treatment

edited by

Nicola Petrosillo

and

Guido Granata

submission deadline 28 Jan 2026 | Viewed by 70 | Submission Open

Keywords: Clostridioides difficile infection; infection control; contact isolation; community-acquired CDI; CDI recurrence; recurrence prevention; rCDI; host and microbiota interaction; antimicrobial treat-ment; microbiota transplant; underdiagnosis

(This special issue belongs to the Section Infectious Diseases)

Inflammatory Bowel Disease: Pathogenesis and Management Strategies

edited by

Jun Kato

submission deadline 28 Jan 2026 | Viewed by 68 | Submission Open

Keywords: inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; biomarkers; risk factors; pharmacology; advanced therapy; endoscopic evaluation and procedures; extraintestinal manifestations; IBD-associated neoplasm

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Hepatitis: Prevention, Treatment, and Global Health Impact

edited by

Michał Brzdęk

Dorota Zarębska-Michaluk

and

Krystyna Dobrowolska

submission deadline 28 Jan 2026 | Viewed by 63 | Submission Open

Keywords: hepatitis B; hepatitis C; liver disease; direct-acting antivirals (DAAs); global health; public health policy; viral hepa-titis elimination; health disparities; cirrhosis; vaccination programs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition

edited by Michael D. Diamantidis

submission deadline 28 Jan 2026 | Viewed by 23 | Submission Open

Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)

(This special issue belongs to the Section Hematology)

Cerebral Palsy: Clinical Rehabilitation and Treatment

edited by Joav Merrick and

Dilipkumar R. Patel

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3985 | Submission Open

Keywords: cerebral palsy; physiotherapy; occupational therapy; orthopedic management; medical management; rehabilitation approaches

(This special issue belongs to the Section Clinical Neurology)

Advances and Perspectives in Cancer Diagnostics and Treatment

edited by Alexandru E. Eniu,

Cristina Marinela Oprean

and

Simona Ruxandra Volovat

submission deadline 30 Jan 2026 | Viewed by 236 | Submission Open

Keywords: solid tumors; new advances; diagnostics and treatment; clinical– pathological; genetic factors; AI; RWD; radiotherapy; biomarkers; prevention in cancer care; target therapy; immunotherapy

(This special issue belongs to the Section Oncology)

The Current Status and Future Directions of Pancreatoduodenectomy and Pancreatectomy

edited by

Vasileios K. Mavroeidis

Samir Pathak

and Somaiah Aroori

submission deadline 30 Jan 2026 | 1 articles | Viewed by 96 | Submission Open

Keywords: pancreatic resection types; techniques and modifications; anastomotic techniques; open resection; minimally invasive surgery; laparoscopic resection; robotic resection; hybrid resection techniques; pancreatic resection post neoadjuvant treatment; lymphadenectomy; vascular resections; organ-sparing procedures; radicality; indications; complications

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Optimal Hybrid Revascularization Approach for Multilevel Peripheral Arterial Disease

edited by

Jin Hyun Joh

submission deadline 30 Jan 2026 | Viewed by 77 | Submission Open

Keywords: peripheral arterial disease; revascularization; endovascular procedure; endarterectomy; limb salvage; patency; hybrid procedures; lower extremity; stents; angioplasty

(This special issue belongs to the Section Vascular Medicine)

Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes

edited by

Damiano Caputo

Roberto Cammarata

and Federica Giordano

submission deadline 30 Jan 2026 | Viewed by 66 | Submission Open

Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile

(This special issue belongs to the Section Oncology)

Mind–Body Connection: The Impact of Mental Health on Physical Well-Being

edited by

Mario Pinto

submission deadline 30 Jan 2026 | Viewed by 60 | Submission Open

Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare

(This special issue belongs to the Section Mental Health)

Insights on Cancer Diagnosis, Treatment and Side Effects Management

edited by

Octav Ginghină

Mihai-Teodor Georgescu

and

Laurentia Nicoleta Gales

submission deadline 30 Jan 2026 | Viewed by 54 | Submission Open

Keywords: cancer diagnosis; cancer treatment; side effects management; oncology; personalized medicine; supportive care

(This special issue belongs to the Section Oncology)

Clinical Outcomes in Bipolar and Depressive Disorders

edited by

Luca J. Steardo

and Francesco Monaco

submission deadline 30 Jan 2026 | Viewed by 46 | Submission Open

Keywords: mood disorders; clinical outcomes; treatment response; psychopathology; pathophysiology

(This special issue belongs to the Section Mental Health)

Atrial Fibrillation and Heart Failure: Diagnostic and Therapeutic Challenges and Breakthroughs

edited by

Silvius Alexandru Pescariu

Felix Bratosin

and

Cristian Mornos

submission deadline 30 Jan 2026 | Viewed by 46 | Submission Open

Keywords: atrial fibrillation; heart failure; cardiac electrophysiology; ventricular remodelling; rhythm control; catheter abla-tion; neurohormonal activation; biomarkers; ischemia; integrated cardiovascular care

(This special issue belongs to the Section Cardiology)

Current Advances in General and Regional Anesthesia

edited by Eleni Laou, Eleana Garini and Giolanda Varvarousi

submission deadline 30 Jan 2026 | Viewed by 33 | Submission Open

Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety

(This special issue belongs to the Section Anesthesiology)

Advances in Minimally Invasive Surgery: Transformative Technologies, Techniques and Trends

edited by Michail Pitiakoudis

submission deadline 30 Jan 2026 | Viewed by 24 | Submission Open

Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical innovation; hernia repair; colorectal surgery; gastrointestinal surgery; hepatopancreatobiliary surgery; surgical simulation; virtual reality; augmented reality; artificial intelligence; surgical training; patient outcomes; surgical oncology

(This special issue belongs to the Section General Surgery)

Diagnosis and Treatment of Obstetrics and Gynecology Cancers

edited by

Gaspare Cucinella

submission deadline 31 Jan 2026 | 1 articles | Viewed by 652 | Submission Open

Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radio-therapy; systemic treatment; immunotherapy; sentinel lymph node biopsy; minimally invasive surgery; fertility preservation; gestational trophoblastic disease

(This special issue belongs to the Section Obstetrics & Gynecology)

Diagnosis and Treatment of Aortic Dissection: Experts' Views

edited by Marja K Hedman and Annastiina Husso

submission deadline 31 Jan 2026 | 1 articles | Viewed by 299 | Submission Open

Keywords: aortic diseases; aortic type A dissection; aortic growth rate; aortic length; aortic imaging

(This special issue belongs to the Section Cardiology)

Clinical Management, Diagnosis and Treatment of Thoracic Diseases: 2nd Edition

edited by

Damiano D’Ardes

and

Andrea Boccatonda

submission deadline 31 Jan 2026 | 1 articles | Viewed by 298 | Submission Open

Keywords: lung; thorax; pneumonia; chest; imaging; ultrasound

(This special issue belongs to the Section Respiratory Medicine)

Revolutionizing Neurosurgery: Cutting-Edge Techniques and Innovations

edited by

Yoichi Morofuji

submission deadline 31 Jan 2026 | Viewed by 157 | Submission Open

Keywords: neuroendovascular surgery; neuroimaging; neurosurgery; neuroendoscopic surgery

(This special issue belongs to the Section Clinical Neurology)

Thoracic Surgery: Updates and New Trends

edited by

Monica Casiraghi

submission deadline 31 Jan 2026 | Viewed by 78 | Submission Open

Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Pushing Boundaries in Cardiac Resynchronization Therapy: Clinical Innovations Transforming Heart Failure Management

edited by István Szokodi and

Attila Kónyi

submission deadline 31 Jan 2026 | Viewed by 68 | Submission Open

Keywords: cardiac resynchronization therapy; heart failure; pacing strategies; patient selection; multi-point pacing; clinical innovations; nonresponders

(This special issue belongs to the Section Cardiology)

Clinical Challenges and Advances in Periodontology and Oral Surgery: 2nd Edition

edited by

Glauco Chisci

submission deadline 31 Jan 2026 | Viewed by 65 | Submission Open

Keywords: oral surgery; third molar; periodontitis; antibiotics; infection; pain; research; advances; complications; dental implants; bone regeneration; maxillofacial surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Acute Coronary Syndromes: Clinical Advances in Diagnosis and Treatment

edited by Pierre Sabouret,

Giuseppe Andò

and

Elad Asher

submission deadline 31 Jan 2026 | Viewed by 64 | Submission Open

Keywords: acute coronary syndromes; myocardial infarction; cardiac biomarkers; antiplatelet therapy; revascularization; precision medicine; risk stratification

(This special issue belongs to the Section Cardiology)

Artificial Intelligence and Machine Learning in Clinical Practice

edited by Theodosis Kalamatianos and

Ioannis Kakkos

submission deadline 31 Jan 2026 | Viewed by 63 | Submission Open

Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis

(This special issue belongs to the Section General Surgery)

Application of Artificial Intelligence in Gastric Cancer

edited by

Lorena Torroni

and

Maria Bencivenga

submission deadline 31 Jan 2026 | Viewed by 59 | Submission Open

Keywords: artificial intelligence (AI); gastric cancer; AI-assisted endoscopy; radiomics; robotic surgery; gastrointestinal diseases; digital pathology; translational research; innovation in healthcare

(This special issue belongs to the Section Oncology)

Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care

edited by

Konstantinos Stathogiannis

submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open

Keywords: TAVI; TAVR; MTEER; TTEER; TTVR; ASD; PFO; IVUS; OCT

(This special issue belongs to the Section Cardiology)

Innovations in Spine Care: Advancing Clinical Solutions and Emerging Technologies

edited by

Luca Ambrosio

submission deadline 31 Jan 2026 | Viewed by 54 | Submission Open

Keywords: artificial intelligence; AI; minimally invasive spine surgery; MIS; endoscopic spine surgery; intervertebral disc regeneration; precision medicine; spine care; spine fusion; osteobiologics

(This special issue belongs to the Section Orthopedics)

Clinical Management and Update of Aortic Dissection and Aortic Aneurysm Diseases

edited by

Makoto Hibino

submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open

Keywords: aortic aneurysm; aortic dissection; aortic surgery; endovascular procedures

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiothoracic and Vascular Anesthesia—Clinical Management and Challenges

edited by Marko Zdravković and

Vlatka Sotosek

submission deadline 31 Jan 2026 | Viewed by 35 | Submission Open

Keywords: cardiac anesthesia; thoracic anesthesia; vascular anesthesia; innovation; perioperative medicine; healthcare; outcomes; challenges

(This special issue belongs to the Section Anesthesiology)

Strategies to Optimize Efficiency of Clear Aligners and Fixed Appliances in the Digital Orthodontics Era

edited by

Maciej Jedliński

submission deadline 31 Jan 2026 | Viewed by 34 | Submission Open

Keywords: clear aligners; fixed orthodontic appliances; digital orthodontics; orthodontic treatment planning; tooth movement efficiency; patient-centered care; treatment modality selection

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Skin Cancer: From Diagnosis to Personalized Treatment

edited by

Anthony J. Dixon

submission deadline 31 Jan 2026 | Viewed by 34 | Submission Open

Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery

(This special issue belongs to the Section Dermatology)

Anesthesia and Pain Management for Women: 2nd Edition

edited by Gaetano Draisci and Stefano Catarci

submission deadline 31 Jan 2026 | Viewed by 32 | Submission Open

Keywords: anesthesia; women; gender differences; acute pain; chronic pain; hormonitoring; pain perception; fibromyalgia; migraine; monitoring; obstetrics; cesarean section; gynecologic surgery

(This special issue belongs to the Section Anesthesiology)

Displaying special issue 1201-1250 on page 25 of 28.

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