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Advances in Structural Heart Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 April 2026 | Viewed by 3856

Special Issue Editors


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Guest Editor
Echocardiography Department, 3rd Cardiology Clinic, Interbalkan Medical Center, Thessaloniki, Greece
Interests: structural heart diseases; valvulopathies; 3D echocardiography; interventional echocardiography; stress echocardiography
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
2nd Cardiology Department, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: 3D echocardiography; myocardial deformation; stress echocardiography; transesophageal echocardiography; transcatheter interventions in valve disease; diabetic heart; systemic inflammatory diseases; cardiomyopathies; heart failure; arterial stiffness; endothelial function
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Cardiology and CIC, University of Rennes, CHU Rennes, Inserm, LTSI-UMR, 35000 Rennes, France
Interests: cardiomyopathies; arrythmias; heart valve diseases; imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The growing demand for transcatheter interventions has introduced the concepts of the “Heart Team” and “Structural Heart Diseases.” This Special Issue, titled “Advances in Structural Heart Diseases”, aims to highlight innovative transcatheter treatments, the critical role of the “Heart Team,” and the importance of cardiac imaging in the planning and management of patients.

Structural heart disease is a subspecialty encompassing conditions such as valvular heart diseases and other pathologies that require multidisciplinary evaluation and transcatheter treatments. Cardiac imaging plays a pivotal role in this field, as the planning and guidance of these procedures rely on advanced imaging modalities, including echocardiography, computed tomography (CT), and cardiac magnetic resonance (CMR).

The wide spectrum of structural heart diseases ranges from simpler congenital defects, such as atrial septal defects (ASDs) and patent foramen ovale (PFO), to complex procedures comprising valvular repair or replacement. This diversity has also fostered the development of a specialized field within imaging—“interventional echocardiography.”

We warmly invite you to contribute to this Special Issue with review articles and original research papers that focus on innovations in transcatheter treatments and underscore the indispensable role of imaging in these techniques.

You may choose our Joint Special Issue in Medicina.

Dr. Konstantinos Papadopoulos
Dr. Ignatios Ikonomidis
Prof. Dr. Erwan Donal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • valvular heart diseases
  • transcatheter interventions
  • TEER
  • LAA closure
  • ASD closure
  • interventional echocardiography
  • multimodality cardiac imaging
  • three-dimensional echocardiography

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Published Papers (2 papers)

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Research

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14 pages, 1289 KB  
Article
Efficacy and Safety of ACURATE neo2 in Valve-in-Valve TAVI: A Prospective Single-Center Study
by Georgios E. Papadopoulos, Ilias Ninios, Sotirios Evangelou, Andreas Ioannidis, Athinodoros Nikitopoulos, George Giannakoulas and Vlasis Ninios
J. Clin. Med. 2025, 14(13), 4677; https://doi.org/10.3390/jcm14134677 - 2 Jul 2025
Viewed by 692
Abstract
Background/Objectives: Valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) is a key approach for treating degenerated surgical bioprosthetic valves. The ACURATE neo2 valve, with its advanced sealing technology and optimized coronary access, represents a promising solution for the challenges of ViV TAVI. This [...] Read more.
Background/Objectives: Valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) is a key approach for treating degenerated surgical bioprosthetic valves. The ACURATE neo2 valve, with its advanced sealing technology and optimized coronary access, represents a promising solution for the challenges of ViV TAVI. This study evaluates the procedural and 30-day and 1-year follow-up outcomes of the ACURATE neo2 valve in ViV TAVI. Methods: This single-center, single-operator prospective study included patients with symptomatic bioprosthetic valve dysfunction, classified in New York Heart Association (NYHA) class III or IV, who underwent ViV TAVI with ACURATE neo2 at our center between July 2022 and February 2024. Outcomes were assessed using VARC-3 criteria. Results: Fifty-five patients (51% females, median (IQR) age 76 (8) years) were included. The technical success rate was 98.2%. No patients experienced in-hospital mortality, stroke, MI, bleeding, vascular complications, renal failure, or new pacemaker implantation. Three patients (5.5%) underwent elective chimney stenting for coronary protection. The postprocedural mean aortic gradient was 6.7 ± 1 mmHg, with a mean aortic valve area (AVA) of 2.0 ± 0.1 cm2. Over a median follow-up period of 1.2 years, no deaths (0%) were observed, heart failure hospitalization rate was 3.6%, and NYHA class improved to ≤II in 100% of patients. Conclusions: ACURATE neo2 demonstrated excellent technical success, sustained hemodynamic performance, and significant clinical improvement in ViV TAVI. The absence of major adverse events reinforces its safety, efficacy, and durability as a treatment for degenerated surgical bioprostheses. Full article
(This article belongs to the Special Issue Advances in Structural Heart Diseases)
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Review

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21 pages, 21264 KB  
Review
Screening and Procedural Guidance for Mitral Transcatheter Edge-to-Edge Repair (M-TEER)
by Andromahi Zygouri, Prayuth Rasmeehirun, Guillaume L’Official, Konstantinos Papadopoulos, Ignatios Ikonomidis and Erwan Donal
J. Clin. Med. 2025, 14(14), 4902; https://doi.org/10.3390/jcm14144902 - 10 Jul 2025
Viewed by 2831
Abstract
Mitral regurgitation (MR) is a common valvular heart disease associated with significant morbidity and mortality. For patients at high or prohibitive surgical risk, mitral transcatheter edge-to-edge repair (M-TEER) offers a less invasive alternative to surgery. This review outlines key aspects of patient selection [...] Read more.
Mitral regurgitation (MR) is a common valvular heart disease associated with significant morbidity and mortality. For patients at high or prohibitive surgical risk, mitral transcatheter edge-to-edge repair (M-TEER) offers a less invasive alternative to surgery. This review outlines key aspects of patient selection and procedural planning for M-TEER, with a focus on clinical and echocardiographic criteria essential for success. Comprehensive imaging—especially 2D and 3D transesophageal echocardiography—is critical to assess leaflet anatomy, coaptation geometry, and mitral valve area. Selection criteria differ between primary and secondary MR and are guided by trials such as COAPT and MITRA-FR. Optimal outcomes rely on careful screening, anatomical suitability, and multidisciplinary evaluation. With growing experience and advancing technology, M-TEER has become a transformative option for treating severe MR in non-surgical candidates. Full article
(This article belongs to the Special Issue Advances in Structural Heart Diseases)
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