Sex- and Age-Related Differences in Exercise Response: Clinical Implications for Health and Disease
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Sports Medicine".
Deadline for manuscript submissions: 26 April 2026 | Viewed by 19
Special Issue Editor
Interests: exercise; skeletal muscle; muscle physiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Exercise has well-established benefits for health promotion, disease prevention, and improving quality of life across the lifespan. However, growing clinical evidence indicates that individual responses to exercise interventions can vary significantly based on factors such as biological sex, age, baseline fitness, and metabolic health status. Understanding these differences is essential for optimizing clinical exercise prescriptions and improving patient outcomes in both preventive and therapeutic settings.
This Special Issue aims to explore variations in the health effects of physical activity across different patient populations, with a particular focus on sex- and age-related differences, as well as variations associated with fitness level or the presence of metabolic disease. Topics of interest include the following:
- The role of sex differences in clinical exercise outcomes, including hormonal influences, cardiometabolic responses, and musculoskeletal adaptations;
- Age-related differences in the effectiveness and recovery from exercise-based interventions, from pediatric to geriatric populations, highlighting the need for age-specific strategies in clinical care;
- The impact of baseline fitness or frailty status on responsiveness to prescribed physical activity in both rehabilitation and chronic disease contexts;
- The role of exercise in managing metabolic disorders such as obesity, insulin resistance, and type 2 diabetes, with an emphasis on individualized, patient-centered interventions.
By highlighting these differential responses, this Special Issue seeks to advance the practice of precision exercise medicine and promote more effective, personalized strategies for using physical activity in clinical health promotion and disease management.
Dr. Rafael A. Casuso
Guest Editor
Manuscript Submission Information
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Keywords
- exercise intervention
- clinical exercise physiology
- sex differences
- age-related response
- metabolic disorders
- personalized medicine
- physical activity
- chronic disease management
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