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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Surgical Treatment and Postoperative Recovery of Heart and Lung Disease

edited by

Yasushige Shingu

submission deadline 20 Dec 2025 | 5 articles | Viewed by 5684 | Submission Open

Keywords: heart and lung disease; complications; frailty; rehabilitation; atrial fibrillation; infections

(This special issue belongs to the Section Cardiovascular Medicine)

Substance and Behavioral Addictions: Prevention and Diagnosis

edited by

Icro Maremmani

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5570 | Submission Open

Keywords: substance addiction; behavioural addiction; clinical perspectives; prevention strategies; diagnostic protocols; differential diagnosis; psychopathology of addiction; psychopathology as a diagnostic tool; craving behavioural covariates

(This special issue belongs to the Section Mental Health)

Trauma and Acute Care Surgery Research: Innovations, Challenges, and Future Directions

edited by Frederick Rogers

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5533 | Submission Open

Keywords: trauma care; best practices; clinical care; trauma system development; optimal trauma care

(This special issue belongs to the Section Intensive Care)

Thoracic Surgery: Current Challenges and Future Perspectives

edited by

Jon Zabaleta

and José Luis Campo-Cañaveral de la Cruz

submission deadline 20 Dec 2025 | 6 articles | Viewed by 5484 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Advances in Leveraging Big Data for Improving Patient Outcomes in Gastrointestinal and Hepatopancreatobiliary Diseases

edited by Saurabh Chawla

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5143 | Submission Open

Keywords: big data; machine learning; artificial intelligence; gastroenterology; research; hepatopancreatobiliary

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances in Extracorporeal Membrane Oxygenation (ECMO)

edited by Camilla L'Acqua

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4752 | Submission Open

Keywords: ECMO; anticoagulation; circuit; global collaboration

(This special issue belongs to the Section Emergency Medicine)

Diagnosis and Treatment of Rheumatic Diseases

edited by Răzvan Gabriel Drăgoi and

Codrina Ancuta

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4075 | Submission Open

Keywords: rheumatic diseases; patient-reported outcomes; assessment; arthritis; impairment; connective tissue diseases; biological and targeted synthetic therapies; impairment

(This special issue belongs to the Section Immunology)

Patient Reported Outcomes (PROs) in Inflammatory Bowel Disease (IBD) Around the World

edited by Irina Blumenstein

submission deadline 20 Dec 2025 | 5 articles | Viewed by 3954 | Submission Open

Keywords: inflammatory bowel disease; patient reported outcomes; symptom burden; quality of life; treatment satisfaction

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Emergency Ultrasound: State of the Art and Perspectives

edited by

Yale Tung-Chen

and

Gonzalo Garcia Casasola

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3647 | Submission Open

Keywords: point-of-care ultrasound; emergency ultrasound; focus cardiac ultrasound; lung ultrasound; shock; venous thromboembolic disease; systemic venous congestion; resuscitation; polytrauma

(This special issue belongs to the Section Emergency Medicine)

Robotic Bariatric Surgery

edited by

Antonio Vitiello

and Vincenzo Pilone

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3556 | Submission Open

Keywords: bariatric surgery; metabolic surgery; sleeve gastrectomy; bariatrics; general surgery; gastric bypass; robotic surgery; robotics

(This special issue belongs to the Section General Surgery)

Perspectives on Congenital Heart Disease from Children to Adults

edited by

Raffaele Giordano

submission deadline 20 Dec 2025 | 4 articles | Viewed by 3392 | Submission Open

Keywords: congenital heart disease; pediatric cardiac surgery; pediatric cardiology; children; adult congenital heart disease

(This special issue belongs to the Section Cardiology)

Advances in Trauma Care and Emergency Medicine

edited by

Lothar Andreas Schwarte

Patrick Schober

and

Georgios F. Giannakopoulos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3379 | Submission Open

Keywords: trauma; trauma care; emergency medicine; pre-hospital; emergency room; intensive care unit

(This special issue belongs to the Section Emergency Medicine)

New Insights in Ophthalmic Surgery

edited by Irina S. Barequet

submission deadline 20 Dec 2025 | 4 articles | Viewed by 3340 | Submission Open

Keywords: cataract surgery; corneal surgery; refractive surgery; ocular surface reconstruction; anterior segment surgery

(This special issue belongs to the Section Ophthalmology)

Clinical Treatment and Management of Rheumatic Diseases, Autoinflammatory Diseases, and Autoimmune Disorders

edited by Merav Lidar and

Abdulla Watad

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3146 | Submission Open

Keywords: rheumatic diseases; autoinflammatory diseases; autoimmune disorders; rheumatoid arthritis; diagnosis

(This special issue belongs to the Section Immunology)

State of the Art in Hand Surgery

edited by Leszek Romanowski and

Piotr Czarnecki

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2773 | Submission Open

Keywords: hand surgery; nerve surgery; state-of-the-art; hand therapy; tendons; thumb arthritis; hand fractures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Pelvic Organ Prolapse: Current Challenges and Future Perspectives

edited by Marco Soligo

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2740 | Submission Open

Keywords: pelvic organ prolapse; urinary incontinence; lower urinary disorders; quality of life; patient-reported outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Perspectives on Acute Coronary Syndrome

edited by

Marius Rus

and

Massimo Mancone

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2593 | Submission Open

Keywords: acute coronary syndrome; ischemic heart disease; multidisciplinary approach; interventional cardiology; new research lines; diagnosis and risk stratification; biomarkers; reperfusion strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition)

edited by

Panagiotis Christopoulos

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2117 | Submission Open

Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Management of Burns: Past, Present and Future

edited by Lior Rosenberg

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1899 | Submission Open

Keywords: history of burn care; burn care infection; inflammation; burn wound care and closure; debridement; traditional Chinese burn care; traditional Indian (Ayurveda) burn care; burn mass casualty incidents (BMCIs); surge capacity; burn pain control; pruritus; burn scar treatment

(This special issue belongs to the Section General Surgery)

Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Hirsh D. Trivedi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1616 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease; MASLD; non-alcoholic fatty liver disease; NAFLD; liver disease; liver fibrosis; metabolic syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Targeted Treatment of Oral Cancer

edited by

Yasmine Ghantous

and

Claudia Malheiros Coutinho-Camillo

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1481 | Submission Open

Keywords: precision medicine; immunotherapy; targeted drugs; combination therapy; tumor immune evasion; clinical trials

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Latest Advances in Orthodontics

edited by

Giuseppina Laganà

submission deadline 20 Dec 2025 | 3 articles | Viewed by 1243 | Submission Open

Keywords: digital treatment planning; clear aligners; skeletal anchorage; OSAS; artificial intelligence

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements in Femtosecond Laser Applications

edited by Luca Schwarzenbacher, Eva Stifter and Philipp Roberts

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1125 | Submission Open

Keywords: femtosecond laser; cataract surgery; DSAEK; DALK; femto-CAIRS; congenital cataract

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Trauma and Orthopaedic Surgery

edited by Valerio Pace and Pierluigi Antinolfi

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1077 | Submission Open

Keywords: orthopaedic surgery; hand/wrist surgery; tendon injury; ligament injury; artificial intelligence (AI); robotic surgery; orthopaedic injections; nerve injury

(This special issue belongs to the Section Orthopedics)

Updates on the Clinical Applications of Dental Restorative Materials

edited by

Vittorio Checchi

submission deadline 20 Dec 2025 | 1 articles | Viewed by 860 | Submission Open

Keywords: restorative dentistry; restorations; adhesive dentistry; resin composites; ceramics; aesthetics; dental materials; direct restorations; indirect restorations; conservative dentistry; prosthetic dentistry; partial restorations; total restorations

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Multiple Sclerosis: Clinical Advances in Diagnosis and Treatment

edited by

Marta Simone

submission deadline 20 Dec 2025 | 1 articles | Viewed by 852 | Submission Open

Keywords: relapse-remitting multiple sclerosis; progressive multiple sclerosis; immunomodulatory treatments; cognitive impairment; personalized medicine in multiple sclerosis

(This special issue belongs to the Section Clinical Neurology)

Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 2nd Edition

edited by Juan Luis Rodriguez Hermosa, José Luis Álvarez-Sala Walther and Myriam Calle Rubio

submission deadline 20 Dec 2025 | 1 articles | Viewed by 851 | Submission Open

Keywords: COPD; diagnosis; comorbidities; respiratory rehabilitation; inhaled therapy; biological therapies

(This special issue belongs to the Section Respiratory Medicine)

Clinical Innovations in Dental Implant: Expanding Possibilities for Oral Rehabilitation

edited by Marco Severino

submission deadline 20 Dec 2025 | 1 articles | Viewed by 763 | Submission Open

Keywords: dental implants; oral rehabilitation; computer-guided surgery; biocompatibility; regenerative treatments; mini-implants; minimally invasive surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Genitourinary Cancers: Clinical Advances and Practice Updates

edited by David Benjamin and Arash Rezazadeh Kalebasty

submission deadline 20 Dec 2025 | 1 articles | Viewed by 674 | Submission Open

Keywords: rare tumors; genitourinary cancers; urachal cancer; penile cancer; testicular cancer; variant histology

(This special issue belongs to the Section Nephrology & Urology)

Advances in Periodontitis and Other Periodontal Diseases

edited by

Giovanna Murmura

submission deadline 20 Dec 2025 | 1 articles | Viewed by 627 | Submission Open

Keywords: periodontal diseases; gingivitis; periodontitis; systemic disease; classification

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Colorectal Surgery: Current Practice and Future Perspectives

edited by

Karel Kostev

submission deadline 20 Dec 2025 | 1 articles | Viewed by 600 | Submission Open

Keywords: colorectal surgery; minimal invasive surgery; open surgery; robot assisted surgery; colorectal cancer; stomach cancer; pancreatic cancer; diverticular disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Challenges and Perspectives in Liver Transplantation

edited by Bogdan Dorobanţu,

Umberto Cillo

and Waldo Concepcion

submission deadline 20 Dec 2025 | 1 articles | Viewed by 588 | Submission Open

Keywords: liver transplantation; liver surgery; liver cirrhosis; liver disease; alcoholic and non-alcoholic steatohepatitis; cholangiocarcinoma; hepatocellular carcinoma; auxiliary liver transplantation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Management of Bladder Cancer

edited by

Antonio Franco

, Antonio Cicione and

Francesco Ditonno

submission deadline 20 Dec 2025 | 1 articles | Viewed by 520 | Submission Open

Keywords: bladder cancer; minimally invasive surgery; immunotherapy; targeted therapy; biomarkers; imaging techniques; muscle invasive bladder cancer; non-muscle-invasive bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Maternal–Fetal Medicine: Current Status, Challenges, and Future Directions

edited by Jessian Munoz

submission deadline 20 Dec 2025 | Viewed by 389 | Submission Open

Keywords: maternal– fetal medicine; preterm delivery; preterm birth management; newborn; obstetrics; high-risk pregnancy; perinatal outcome; placenta accreta; fetal surgery

(This special issue belongs to the Section Obstetrics & Gynecology)

New Insights in Maxillofacial Surgery

edited by

Izumi Asahina

submission deadline 20 Dec 2025 | 1 articles | Viewed by 331 | Submission Open

Keywords: maxillofacial surgery; surgical techniques; imaging technologies; biomaterials; regenerative medicine

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Novel Diagnostic and Therapeutic Strategies in Vitreoretinal Disease

edited by Jerzy Mackiewicz and

Mateusz Winiarczyk

submission deadline 20 Dec 2025 | Viewed by 281 | Submission Open

Keywords: retinal detachment; vitreoretinal diseases; PPV; vitrectomy; macular edema; uveitis; AMD; retinal imaging; retinal pathology; diabetic retinopathy; optical coherent tomography; OCT

(This special issue belongs to the Section Ophthalmology)

Innovative Treatment and Management Strategies for Inflammatory Bowel Disease

edited by Syed Adeel Hassan and

Neeraj Kapur

submission deadline 20 Dec 2025 | Viewed by 242 | Submission Open

Keywords: Crohn’ s disease; ulcerative colitis; efficacy; safety; nutrition; surgery; biomarkers

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights

edited by

Shinichi Watanabe

Nobuto Nakanishi

and

Yuki Iida

submission deadline 20 Dec 2025 | Viewed by 224 | Submission Open

Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Diagnosis and Treatment of Urological Cancers

edited by Davide Campobasso,

Stefano Puliatti

and

Daniele Amparore

submission deadline 20 Dec 2025 | 1 articles | Viewed by 218 | Submission Open

Keywords: prostate cancer; kidney cancer; urothelial carcinoma; testis cancer; mini-invasive surgery; precision surgery; target therapy; immunotherapy; nuclear medicine; artificial intelligence; augmented reality; biomarkers; prognostic factors and models; focal therapy; radiotherapy; imaging; genetics

(This special issue belongs to the Section Nephrology & Urology)

Transformative Research in Hydrocephalus: Clinical Advances

edited by Afroditi D. Lalou, Zofia Helena Czosnyka and Marek Czosnyka

submission deadline 20 Dec 2025 | Viewed by 208 | Submission Open

Keywords: cerebrospinal fluid dynamics; CSF shunt; intracranial pressure monitoring; telemetric ICP; hydrocephalus pathophysiology; neuroimaging; paediatric hydrocephalus; adult hydrocephalus; translational neuroscience

(This special issue belongs to the Section Clinical Neurology)

Antithrombotic Therapies for Acute Coronary Syndrome and Atrial Fibrillation

edited by

Mojca Božič Mijovski

submission deadline 20 Dec 2025 | Viewed by 169 | Submission Open

Keywords: atrial fibrillation; acute coronary syndrome; antiplatelet agents; anticoagulants; thrombolysis; direct coagulation factor inhibitors; medical laboratory technology

(This special issue belongs to the Section Cardiology)

Anesthesia and Intensive Care in Orthopedic and Trauma Surgery

edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi

submission deadline 20 Dec 2025 | Viewed by 157 | Submission Open

Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium

(This special issue belongs to the Section Intensive Care)

New Clinical Advances in Breast Reconstruction

edited by

Nobuyuki Mitsukawa

submission deadline 20 Dec 2025 | Viewed by 109 | Submission Open

Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Risk Factors in Neonatal Intensive Care

edited by

Gabriela C. Zaharie

and

Melinda Matyas

submission deadline 20 Dec 2025 | Viewed by 94 | Submission Open

Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity

(This special issue belongs to the Section Clinical Pediatrics)

Key Challenges in Heart Transplantation and Their Solutions

edited by Elizabeth J. Maynes

submission deadline 20 Dec 2025 | Viewed by 91 | Submission Open

Keywords: heart transplantation; heart failure; cardiac surgery; minimally invasive techniques; general surgery; heart diseases

(This special issue belongs to the Section Cardiology)

Current and Emerging Treatment Options in Intestinal and Stomach Neoplasms

edited by

Ioannis Konstantinidis

submission deadline 20 Dec 2025 | Viewed by 83 | Submission Open

Keywords: colorectal cancer; colon cancer; gastric carcinoma; malignancy; gastroenterology; endoscopic techniques; therapeutic advancements; intestinal neoplasms

(This special issue belongs to the Section Oncology)

New Perspectives in Maternal–Fetal Medicine

edited by Catalina de Paco-Matallana

submission deadline 20 Dec 2025 | Viewed by 81 | Submission Open

Keywords: maternal– fetal medicine; prenatal diagnostics; fetal therapy; precision medicine; neonatal outcomes; maternal health

(This special issue belongs to the Section Obstetrics & Gynecology)

Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes

edited by Thomas Mokrusch and Frank Kirchhoff

submission deadline 20 Dec 2025 | Viewed by 80 | Submission Open

Keywords: neurorehabilitation; therapeutic approaches; repair mechanism; plasticity; neurology

(This special issue belongs to the Section Clinical Neurology)

Recent Developments in Urinary Incontinence

edited by

Michael Samarinas

submission deadline 20 Dec 2025 | Viewed by 75 | Submission Open

Keywords: urinary incontinence; overactive bladder; stress urinary incontinence; pelvic floor dysfunction; urodynamics; minimally invasive treatment; neuromodulation; regenerative medicine; conservative management; digital health in urology

(This special issue belongs to the Section Nephrology & Urology)

Surgical Oncology: Clinical Application of Translational Medicine

edited by Domenico Parmeggiani

submission deadline 20 Dec 2025 | Viewed by 73 | Submission Open

Keywords: surgical oncology; drug safety; adverse events; nanovesicles; targeted drug delivery; cancer biomarkers; precision oncology; tumor microenvironment; nanomedicine; personalized medicine; diagnostics; prognosis; innovative therapies; translational research

(This special issue belongs to the Section Oncology)

Displaying special issue 951-1000 on page 20 of 29.

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