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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management in Chronic Pain: Innovations, Integration, and Interventions

edited by Giuliano Lo Bianco, Silvia Natoli and Sean Li

submission deadline 20 Mar 2026 | Viewed by 98 | Submission Open

Keywords: chronic pain; clinical management; interventional pain medicine; spinal cord stimulation; regenerative medicine; diagnostic strategies; pain semeiotics; multidisciplinary approaches; personalized medicine; pain assessment; neuromodulation; evidence-based pain therapy

(This special issue belongs to the Section Clinical Neurology)

Atrial Fibrillation: Screening, Management and Outcomes

edited by Ahmed AlTurki and Vidal Essebag

submission deadline 20 Mar 2026 | Viewed by 96 | Submission Open

Keywords: atrial fibrillation; ablation; pulmonary vein isolation; atrial fibrillation screening; wearable devices; anti-arrhythmic drugs; cardiovascular outcomes; subclinical atrial fibrillation

(This special issue belongs to the Section Cardiology)

Periodontitis and Systemic Health: Exploring the Oral-Systemic Connection

edited by

Yiorgos Bobetsis

and Phoebus Madianos

submission deadline 20 Mar 2026 | Viewed by 95 | Submission Open

Keywords: periodontal disease; systemic diseases; cardiovascular disease; diabetes mellitus; adverse pregnancy outcomes; respiratory disease; neurodegenerative disorders; obesity; respiratory diseases; chronic kidney disease

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Machine Learning in Vascular Surgery

edited by

George N. Kouvelos

Konstantinos Spanos

and

Konstantinos Dakis

submission deadline 20 Mar 2026 | Viewed by 95 | Submission Open

Keywords: machine learning; artificial intelligence; vascular surgery

(This special issue belongs to the Section Vascular Medicine)

Exercise and Chronic Pain

edited by Nuria Marín-Jiménez and Milkana Borges-Cosic

submission deadline 20 Mar 2026 | Viewed by 92 | Submission Open

Keywords: chronic pain; exercise therapy; physical activity; fitness; pain management; quality of life; non-pharmacological interventions

(This special issue belongs to the Section Sports Medicine)

Minimally Invasive and Endoscopic Neurosurgery

edited by

Nikolaos Gkantsinikoudis

, Vassilios Tsitouras and Stylianos Kapetanakis

submission deadline 20 Mar 2026 | Viewed by 92 | Submission Open

Keywords: traumatic brain injury; neuro-oncology; hydrocephalus and cerebrospinal fluid disorders; neuroendoscopy; endo-scopic neurosurgery; skull base surgery; vascular neurosurgery; functional neurosurgery; pediatric neurosurgey; minimally invasive spine surgery; endoscopic spine surgery; spine endoscopy

(This special issue belongs to the Section Clinical Neurology)

Bladder Cancer: Diagnosis and Treatments

edited by

Stanislav Źiaran

submission deadline 20 Mar 2026 | Viewed by 91 | Submission Open

Keywords: bladder cancer; urothelial cancer; radical cystectomy; targeted therapy; immunotherapy; non-muscle -invasive; muscle-invasive; chemotherapy

(This special issue belongs to the Section Nephrology & Urology)

Clinical Challenges and Future Directions of Interstitial Lung Disease

edited by

Yoshiaki Zaizen

submission deadline 20 Mar 2026 | Viewed by 90 | Submission Open

Keywords: interstitial lung disease; progressive pulmonary fibrosis; early detection; clinical diagnosis; multidisciplinary discussion; treatment; non-pharmacological therapy; end-of-life care; patient-centered management

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Maternal–Fetal Medicine: 2nd Edition

edited by

Erich Cosmi

submission deadline 20 Mar 2026 | Viewed by 86 | Submission Open

Keywords: precision medicine; omics; clinical; fetus; Doppler

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Diagnosis and Treatment of Endometriosis

edited by

Arrigo Fruscalzo

and

Anis Feki

submission deadline 20 Mar 2026 | Viewed by 86 | Submission Open

Keywords: endometriosis; adenomyosis; diagnosis; classification; therapy; progesterone

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Laryngeal Cancer

edited by

Gunnar Wichmann

and

Theresa Wald

submission deadline 20 Mar 2026 | Viewed by 82 | Submission Open

Keywords: head and neck cancer (HNC); laryngeal cancer; larynx organ preservation; immuno-oncology; biomarker; prognostic factor; genetic risk factors; outcome research

(This special issue belongs to the Section Otolaryngology)

Acute Cardiovascular Care in Cardio-Oncology: Present Challenges and Future Pathways

edited by

Raffaele Bugiardini

and Maria Bergami

submission deadline 20 Mar 2026 | Viewed by 82 | Submission Open

Keywords: cardiotoxicity; cardio-oncology; acute cardiovascular care; acute cardiovascular complications; disparities in care

(This special issue belongs to the Section Cardiovascular Medicine)

Minimally Invasive Thoracic Surgery: State of the Art and Future Perspectives

edited by Dustin M. Walters

submission deadline 20 Mar 2026 | Viewed by 75 | Submission Open

Keywords: thoracic surgery; perioperative outcomes; lung cancer resection; minimally invasive surgery; robotic thoracic surgery

(This special issue belongs to the Section Respiratory Medicine)

Current Challenges in Oral Surgery and Pathology

edited by

Christian Bacci

submission deadline 20 Mar 2026 | Viewed by 74 | Submission Open

Keywords: oral medicine; oral pathology; oral surgery; ONJ; MRONJ; BRONJ; laser

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Emerging Insights into Glaucoma, Cataracts, and Refractive Surgery

edited by

Michele Lanza

submission deadline 20 Mar 2026 | Viewed by 73 | Submission Open

Keywords: trabeculoplasty; MIGS; MIBS; trabeculectomy; IOL; biometry; phacoemulsification; femto-cataract; refractive cataract; excimer laser; PRK; femto; LASIK; SMILE; aberrometry; tomography

(This special issue belongs to the Section Ophthalmology)

Bridging Bench, Bedside, and Beyond: Clinical and Translational Strategies for Pregnancy Complications

edited by

Thenral Socrates

and Federica Piani

submission deadline 20 Mar 2026 | Viewed by 71 | Submission Open

Keywords: high-risk pregnancy; cardiovascular complications; cardiometabolic complications; gestational diabetes; pregnancy complications; preeclampsia; hypertension; vascular disorders; endothelial dysfunction; clinical prediction; antenatal diagnosis; personalized treatment

(This special issue belongs to the Section Obstetrics & Gynecology)

Emerging Research in Cancer Survivorship

edited by

Elham Mohebbi

submission deadline 20 Mar 2026 | Viewed by 69 | Submission Open

Keywords: cancer survivorship; clinical epidemiology; quality of life; health system; sexual health; mental health; comorbidities; pain management; tobacco cessation; alcohol abstinence; diet

(This special issue belongs to the Section Epidemiology & Public Health)

Intracranial Aneurysms: What Do We Know So Far?

edited by Alessio Albanese and Giuseppe Esposito

submission deadline 20 Mar 2026 | Viewed by 66 | Submission Open

Keywords: intracranial aneurysms; clipping; endovascular therapy; stenting; coiling; cerebral vasospasm; cerebrovascular diseases; microneurosurgery; subarachnoid hemorrhage; bypass

(This special issue belongs to the Section Clinical Neurology)

Advancements and Challenges in Retina Surgery: Second Edition

edited by Joaquín Marticorena and

Javier Zarranz-Ventura

submission deadline 20 Mar 2026 | Viewed by 56 | Submission Open

Keywords: retina; vitreoretinal diseases; vitreotomes; optical coherence tomography; vitreoretinal surgery

(This special issue belongs to the Section Ophthalmology)

Advances and Challenges in Colorectal Cancer

edited by Vignesh Narasimhan

submission deadline 20 Mar 2026 | Viewed by 56 | Submission Open

Keywords: anal fistula; advancement flap; ‎ ligation of intersphincteric tract; haemorrhoid surgery; pilonidal surgery

(This special issue belongs to the Section Oncology)

Current Paradigms in Pulmonary Vascular Disease: Past, Present and Future

edited by Parth M. Rali

submission deadline 20 Mar 2026 | Viewed by 55 | Submission Open

Keywords: pulmonary hypertension (PH); pulmonary embolism (PE); rare pulmonary vascular disorders; novel therapeutics; di-agnostic innovations

(This special issue belongs to the Section Respiratory Medicine)

Updates in the Use of Pharmacogenetics in Clinical Practice

edited by Rocío Morón Romero and Xando Díaz-Villamarín

submission deadline 20 Mar 2026 | Viewed by 53 | Submission Open

Keywords: pharmacogenetics; personalized medicine; clinical implementation; drug response; pharmacogenomics; precision medicine; healthcare integration; decision support; clinical implications of genetic testing

(This special issue belongs to the Section Pharmacology)

Rectal Cancer: Screening, Treatment and Prevention

edited by Fernando Mendoza-Moreno

submission deadline 20 Mar 2026 | Viewed by 45 | Submission Open

Keywords: rectal cancer; cancer screening; neoadjuvant therapy; minimally invasive surgery; oncologic outcomes; multidiscipli-nary care; health disparities

(This special issue belongs to the Section Oncology)

Clinical Updates and Perspectives on Subarachnoid Hemorrhage: 2nd Edition

edited by

Fusao Ikawa

submission deadline 20 Mar 2026 | Viewed by 37 | Submission Open

Keywords: subarachnoid hemorrhage; outcome of subarachnoid hemorrhage; delayed cerebral ischemia; ruptured cerebral aneurysm; unruptured cerebral aneurysm; artificial intelligence; epidemiology

(This special issue belongs to the Section Clinical Neurology)

Personalized Medicine and Treatment in Inflammatory Bowel Diseases

edited by Carmen Monica Preda and

Cristian George Tieranu

submission deadline 21 Mar 2026 | Viewed by 94 | Submission Open

Keywords: personalized medicine; inflammatory bowel diseases (IBDs); Crohn’ s disease; ulcerative colitis; biomarkers; pharmacogenomics; microbiome; anti-TNF therapy; precision medicine; machine learning

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Perspectives on Foot and Ankle Surgery

edited by Kenichiro Nakajima

submission deadline 24 Mar 2026 | 3 articles | Viewed by 6920 | Submission Open

Keywords: foot and ankle; minimally invasive surgery; surgical techniques; new technologies; diagnosis; clinical assessment

(This special issue belongs to the Section Orthopedics)

Orthodontics: Current Advances and Future Options

edited by

Domenico Ciavarella

and

Michele Tepedino

submission deadline 25 Mar 2026 | 22 articles | Viewed by 39391 | Submission Open

Keywords: digital orthodontics; functional devices; cranial growth; orthodontic therapy; customized devices

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Musculoskeletal Disorders: Clinical Diagnosis, Treatment and Rehabilitation

edited by

Jaime Almazán-Polo

and

César Calvo-Lobo

submission deadline 25 Mar 2026 | 7 articles | Viewed by 24365 | Submission Open

Keywords: musculoskeletal disorders; therapeutic exercise; functional evaluation; rehabilitation protocols; musculoskeletal ultrasound; biomechanical aná lisis; quality of life; functional assessment of the musculoskeletal system; strength training; physical therapy; morphofunctional assessment; conservative treatments; range of motion evaluation; randomized controlled trials

(This special issue belongs to the Section Clinical Rehabilitation)

New Directions for Treatment and Assessment of Ulcerative Colitis

edited by

Andrea van der Meulen

and

Christian Selinger

submission deadline 25 Mar 2026 | 4 articles | Viewed by 18131 | Submission Open

Keywords: treatment; ulcerative colitis; treatment target; ultrasound assessment; approach

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advancements in Venous Disease Management: From Conservative to Interventional Treatments

edited by

Daniele Bissacco

and Chiara Lomazzi

submission deadline 25 Mar 2026 | 2 articles | Viewed by 12103 | Submission Open

Keywords: chronic venous disease; varicose veins; venoactive drugs; saphenous vein; venous stent; iliac vein; compression therapy; venous insufficiency

(This special issue belongs to the Section Vascular Medicine)

New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

edited by

Massimo Tusconi

, Serdar Dursun and

Germano Orru

submission deadline 25 Mar 2026 | 4 articles | Viewed by 10515 | Submission Open

Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD

(This special issue belongs to the Section Mental Health)

Clinical Management for Metabolic Syndrome and Obesity

edited by

Ignacio Díez López

and Antonio De Arriba-Muñoz

submission deadline 25 Mar 2026 | 5 articles | Viewed by 10044 | Submission Open

Keywords: obesity; metabolic syndrome; estatosis hepatic; diabetes mellitus; children; GLP-1

(This special issue belongs to the Section Endocrinology & Metabolism)

Current Advances in Aortic Valve Stenosis

edited by

Antonios Halapas

submission deadline 25 Mar 2026 | 6 articles | Viewed by 9234 | Submission Open

Keywords: valvular heart diseases; aortic stenosis; prevention; diagnosis; management

(This special issue belongs to the Section Cardiology)

Innovations and Advances in Breast Cancer Research and Treatment

edited by

Palma Fedele

submission deadline 25 Mar 2026 | 5 articles | Viewed by 8403 | Submission Open

Keywords: breast cancer; early detection; genomics; personalized medicine; targeted therapies; survivorship; quality of life; artificial intelligence; machine learning; immunotherapy

(This special issue belongs to the Section Oncology)

Advances in Stigma and Discrimination in Pediatric Mental Health

edited by

Clara González-Sanguino

and

Jairo Rodríguez-Medina

submission deadline 25 Mar 2026 | 4 articles | Viewed by 8378 | Submission Open

Keywords: stigma; discrimination; childhood; mental health; clinical psychology

(This special issue belongs to the Section Mental Health)

Airway Management: From Basic Techniques to Innovative Technologies

edited by Kunal Karamchandani and Sheila Nainan Myatra

submission deadline 25 Mar 2026 | 4 articles | Viewed by 6750 | Submission Open

Keywords: airway management; physiologically difficult airway; videolaryngoscopy; esophageal intubation; artificial intelligence

(This special issue belongs to the Section Intensive Care)

Psoriasis and Psoriatic Arthritis: How to Treat in the Era of Biologics and Small Molecule Inhibitors: 3rd Edition

edited by

Mayumi Komine

and

Takemichi Fukasawa

submission deadline 25 Mar 2026 | 2 articles | Viewed by 6355 | Submission Open

Keywords: psoriasis; psoriatic arthritis; biologics; small molecule inhibitors; conventional therapies

(This special issue belongs to the Section Dermatology)

Innovations in Head and Neck Surgery

edited by

Achille Tarsitano

and Giovanni Badiali

submission deadline 25 Mar 2026 | 3 articles | Viewed by 6341 | Submission Open

Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation

(This special issue belongs to the Section Otolaryngology)

Biomarkers and Diagnostics in Neurological Diseases

edited by Maria Ioanna Stefanou

submission deadline 25 Mar 2026 | 5 articles | Viewed by 5855 | Submission Open

Keywords: biomarkers; neurological diseases; diagnosis; lipoprotein(a); neurofilament protein; tau peptide; neuroimaging

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Valvular Heart Diseases

edited by

Mohammad Kassar

submission deadline 25 Mar 2026 | 3 articles | Viewed by 5544 | Submission Open

Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis

(This special issue belongs to the Section Cardiology)

Aortic Aneurysms: Recent Advances in Diagnosis and Treatment

edited by Marco Virgilio Usai, Giuseppe Asciutto and Michele Piazza

submission deadline 25 Mar 2026 | 5 articles | Viewed by 5015 | Submission Open

Keywords: aortic aneurysms; abdominal aortic; thoraco-abdominal aortic aneurysms (TAAAs); complex aortic anatomies; endovascular abdominal aortic aneurysm repair (EVAR); endovascular thoracic aortic aneurysm repair (TEVAR); endovascular treatment

(This special issue belongs to the Section Cardiovascular Medicine)

The Current State of Robotic Surgery in Urology

edited by

Luca Di Gianfrancesco

submission deadline 25 Mar 2026 | 5 articles | Viewed by 4617 | Submission Open

Keywords: robotic surgery; urology; surgical technique; multi-port; single port; major urological surgery; reconstructive surgery; robot-assisted radical cystectomy; patients’ selection

(This special issue belongs to the Section Nephrology & Urology)

Cardiac Surgery: Clinical Advances

edited by Carmelo Dominici, Giovanni Casali and

Antonio Nenna

submission deadline 25 Mar 2026 | 5 articles | Viewed by 4602 | Submission Open

Keywords: cardiac surgery; surgical innovation; minimally invasive techniques; robotic surgery; personalized medicine; advanced surgical technologies

(This special issue belongs to the Section Cardiology)

Obstructive Sleep Apnea: Latest Advances and Prospects

edited by

Carlos O’Connor Reina

submission deadline 25 Mar 2026 | 4 articles | Viewed by 4393 | Submission Open

Keywords: obstructive sleep apnea; sleep medicine; myofunctional therapy; sleep surgery; neurostimulation; personalized treatment; biomarkers; adherence; home sleep testing

(This special issue belongs to the Section Otolaryngology)

Multiple Sclerosis and Demyelinating Diseases: Diagnosis, Treatment and Prognosis

edited by Alberto Gajofatto

submission deadline 25 Mar 2026 | 2 articles | Viewed by 4034 | Submission Open

Keywords: multiple sclerosis; neuromyelitis optica; MOG-antibody disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Clinical Neurology)

Attention-Deficit–Hyperactivity Disorder (ADHD): Bridging Theory and Clinical Application

edited by Rafał R. Jaeschke

submission deadline 25 Mar 2026 | 2 articles | Viewed by 3076 | Submission Open

Keywords: ADHD; emotional dysregulation; diagnosis and assessment; pharmacological and non-pharmacological treatments; neurobiology; comorbidities

(This special issue belongs to the Section Mental Health)

Imaging and Surgery in Endometriosis—Recent Advances

edited by

Harald Krentel

and

Rudy Leon De Wilde

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2986 | Submission Open

Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems

(This special issue belongs to the Section Obstetrics & Gynecology)

Hepatobiliary and Pancreatic (HPB) Surgery: Current Status and Future Perspectives

edited by Andrea Benedetti Cacciaguerra and Paolo Vincenzi

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2845 | Submission Open

Keywords: hepatobiliary and pancreatic surgery; laparoscopic surgery; robot-assisted surgery; artificial intelligence; augmented reality; indocyanine green; liver tumors; pancreatic tumors

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Acute Care for Traumatic Injuries and Surgical Outcomes: 2nd Edition

edited by Matthias Fröhlich and Michael Caspers

submission deadline 25 Mar 2026 | 3 articles | Viewed by 2452 | Submission Open

Keywords: trauma injuries; orthopedics; polytrauma; emergency care; coagulation disorders; fractures; surgical outcomes; acute care; diagnostic imaging

(This special issue belongs to the Section Emergency Medicine)

Diagnostic and Therapeutic Challenges in Infective Endocarditis

edited by Lorenzo Bertolino

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2415 | Submission Open

Keywords: infective endocarditis; complications; diagnostic challenges; therapeutic approach; epidemiology; clinical correlates

(This special issue belongs to the Section Cardiology)

Displaying special issue 951-1000 on page 20 of 31.

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