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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Head and Neck Surgery
edited by Lisa Catarzi, and
submission deadline 25 Sep 2025 | Viewed by 115 | Submission Open
Keywords: head and neck surgery; reconstructive surgery; microsurgical reconstruction; new technologies; computer-assisted surgery; surgical innovation; post-operative care
(This special issue belongs to the Section Otolaryngology)
Clinical Progress in Microsurgical Reconstruction: 2nd Edition
edited by
submission deadline 25 Sep 2025 | Viewed by 98 | Submission Open
Keywords: microsurgery; supermicrosurgery; microvascular anastomosis; head and neck reconstruction; oro-maxillofacial re-construction; plastic and reconstructive surgery; limb reconstruction; breast reconstruction; genital reconstruc-tion; lymphedema; lymph nodes transfer; facial reanimation
(This special issue belongs to the Section General Surgery)
Attention-Deficit–Hyperactivity Disorder (ADHD): Bridging Theory and Clinical Application
edited by Rafał R. Jaeschke
submission deadline 25 Sep 2025 | Viewed by 98 | Submission Open
Keywords: ADHD; emotional dysregulation; diagnosis and assessment; pharmacological and non-pharmacological treatments; neurobiology; comorbidities
(This special issue belongs to the Section Mental Health)
New Advances in Age-Related Macular Degeneration
edited by Omer Trivizki
submission deadline 25 Sep 2025 | Viewed by 97 | Submission Open
Keywords: wet age-related macular degeneration; dry age-related macular degeneration; retinal imaging; drusen; intravitreal injections; ocular angiogenesis; visual rehabilitation
(This special issue belongs to the Section Ophthalmology)
Clinical Management of Complications Following Kidney Transplant Surgery
edited by Ryoichi Imamura
submission deadline 25 Sep 2025 | Viewed by 90 | Submission Open
Keywords: kidney transplantation; complication; rejection; infectious disease; de novo cancer; cardiovascular disease; biomarkers
(This special issue belongs to the Section Nephrology & Urology)
Advanced Therapy for Heart Failure and Other Combined Diseases
edited by Gori Mauro and Marco Marini
submission deadline 25 Sep 2025 | Viewed by 80 | Submission Open
Keywords: heart failure with reduced and preserved ejection fraction; advanced heart failure; inotropes; acute heart failure; GDMT
(This special issue belongs to the Section Cardiology)
Clinical Application of Artificial Intelligence in Vascular Surgery
edited by
submission deadline 25 Sep 2025 | Viewed by 74 | Submission Open
Keywords: artificial intelligence; machine learning; vision; vascular imaging; natural language processing; innovation; vascular surgery; vascular diseases; endovascular; aortic disease; carotid disease; peripheral artery disease; venous disease
(This special issue belongs to the Section Vascular Medicine)
Treatment Strategies for Prostate Cancer: An Update submission deadline 25 Sep 2025 | Viewed by 73 | Submission Open
Keywords: prostate cancer; robotic surgery; uro-oncology; focal therapy; single-port; radiotherapy
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances and Challenges in Laparoscopic Surgery
edited by Leonid Barkhatov
submission deadline 25 Sep 2025 | Viewed by 72 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; surgical outcomes; oncologic surgery; general surgery; learning curve
(This special issue belongs to the Section General Surgery)
State of the Art in Clinical Management of Sedation and Anesthesia Challenges
edited by Basavana Goudra
submission deadline 25 Sep 2025 | Viewed by 43 | Submission Open
Keywords: anesthesia; oxygenation; sedative agents; ventilation; airway management
(This special issue belongs to the Section Anesthesiology)
Vascular and Endovascular Surgery: Current Progress and Future Challenges
edited by Michael Keese and Martin Sigl
submission deadline 28 Sep 2025 | 5 articles | Viewed by 4060 | Submission Open
Keywords: vascular; endovascular; surgery; therapy; aneurysm; vascular; PAD; venous; interdisciplinary
(This special issue belongs to the Section Vascular Medicine)
New Perspectives in Liver Transplantation and Biliary Complications
edited by and Francesco Frongillo
submission deadline 28 Sep 2025 | 3 articles | Viewed by 2762 | Submission Open
Keywords: liver transplant; cholangiopathy; ischemia/reperfusion injury; machine perfusion; extended-criteria donors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Echocardiographic Imaging in Transcatheter Structural Intervention: Current Practices and Future Directions
edited by and Fausto Pizzino
submission deadline 28 Sep 2025 | 1 articles | Viewed by 2021 | Submission Open
Keywords: echocardiographic imaging; transcatheter intervention; aortic stenosis; mitral regurgitation; tricuspid regurgitation; left atrial appendage closure; patent foramen ovale closure; atrial septal defect repair
(This special issue belongs to the Section Cardiology)
High-Flow Nasal Cannula (HFNC) and Noninvasive Ventilation: What Is New in Acute, Chronic and Rehabilitation Settings? submission deadline 28 Sep 2025 | 1 articles | Viewed by 1583 | Submission Open
Keywords: NIV; HFNC; noninvasive ventilation; acute respiratory insufficiency; chronic respiratory insufficiency
(This special issue belongs to the Section Respiratory Medicine)
Clinical Management and Treatment of Orthopedic Oncology: 2nd Edition
edited by and Danielle Elizabeth Greig
submission deadline 28 Sep 2025 | 2 articles | Viewed by 838 | Submission Open
Keywords: bone metastasis; primary bone tumors; soft tissue sarcoma; limb salvage; multimodal treatment strategies
(This special issue belongs to the Section Orthopedics)
Current Progress in the Treatment of Cornea and Ocular Surface Diseases
edited by Marco Messina and
submission deadline 28 Sep 2025 | 1 articles | Viewed by 495 | Submission Open
Keywords: dry eye disease; meibomian gland dysfunction; microbial keratitis; auto-immune keratitis; peripheral ulcerative keratitis; neurotrophic keratopathy; corneal dystrophies; corneal degenerations; mucous membrane pemphigoid; ocular cicatricial disease; Stevens– Johnson syndrome; pterygium; ocular graft-versus-host disease; limbal stem cell deficiency; keratoplasty; amniotic membrane transplantation; keratoconus; corneal collagen cross-linking; antimicrobial therapy; corneal neurotization; vernal keratoconjunctivitis; atopic keratoconjunctivitis
(This special issue belongs to the Section Ophthalmology)
Advances in the Diagnosis, Treatment of Intestinal Cancer: 2nd Edition
edited by and
submission deadline 28 Sep 2025 | Viewed by 97 | Submission Open
Keywords: colorectal cancer; early detection; treatment; immune therapy; radiation therapy; chemotherapy; risk factors; improved prognosis
(This special issue belongs to the Section Oncology)
New Advances in COVID-19 and Pregnancy
edited by
submission deadline 30 Sep 2025 | 12 articles | Viewed by 17048 | Submission Open
Keywords: COVID-19 and pregnancy; SARS-CoV-2 infection; maternal mortality and morbidity; pregnancy complication; management protocol; maternal comorbidities; severe disease; prevention; diagnosis; treatment; management
(This special issue belongs to the Section Obstetrics & Gynecology)
Orthodontics: Current Advances and Future Options submission deadline 30 Sep 2025 | 11 articles | Viewed by 11277 | Submission Open
Keywords: digital orthodontics; functional devices; cranial growth; orthodontic therapy; customized devices
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Atrial Fibrillation and Its Complications: Preventive Strategies and Relative Evidence
edited by Roberto Galea
submission deadline 30 Sep 2025 | 7 articles | Viewed by 10210 | Submission Open
Keywords: atrial fibrillation; catheter ablation; oral anticoagulation; left atrial appendage closure; stroke prevention
(This special issue belongs to the Section Cardiology)
New Insights into Pancreatic Surgery
edited by Mario Serradilla-Martín and José Manuel Ramia
submission deadline 30 Sep 2025 | 5 articles | Viewed by 7805 | Submission Open
Keywords: pancreas; pancreatectomy; surgery; outcomes; cancer; fistula; minimally invasive surgery; IPMT
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Advances in Facial Palsy Management
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 7538 | Submission Open
Keywords: facial palsy; transplantation; facial cybernetics; facial therapy; nerve supermicrosurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Advances in Malaria
edited by Marc Thellier
submission deadline 30 Sep 2025 | 2 articles | Viewed by 7456 | Submission Open
Keywords: malaria; diagnosis; treatment; vaccination; resistance; epidemiology; public health
(This special issue belongs to the Section Infectious Diseases)
Diagnosis, Treatment, and Prevention of Glaucoma: Second Edition submission deadline 30 Sep 2025 | 6 articles | Viewed by 7137 | Submission Open
Keywords: glaucoma; OCT; visual field; blindness; glaucoma surgery; intraocular pressure; glaucoma prevention; glaucoma treatment
(This special issue belongs to the Section Ophthalmology)
Chronic Kidney Disease: Clinical Challenges and Management submission deadline 30 Sep 2025 | 5 articles | Viewed by 5554 | Submission Open
Keywords: chronic kidney disease; clinical trial; end-stage renal disease; kidney dysfunction; management; challenge
(This special issue belongs to the Section Nephrology & Urology)
Clinical Diagnosis of Lung Cancer
edited by Andrea Bille and
submission deadline 30 Sep 2025 | 4 articles | Viewed by 4922 | Submission Open
Keywords: biomarkers; bronchoscopy; diagnosis; imaging; liquid biopsy; lung cancer; mediastinoscopy; minimally invasive surgery; pathology; screening; staging
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Ischemic Heart Disease
edited by Stefano Schena and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3829 | Submission Open
Keywords: multidisciplinary approach; modern imaging; myocardial pre-habilitation; revascularization in severe ischemic cardiomyopathy; guidelines; complex PCI; hybrid treatment; minimally invasive surgery
(This special issue belongs to the Section Cardiology)
Gastrointestinal Endoscopy: Clinical Advances in Diagnosis and Treatment, 2nd Edition
edited by Joao Santos-Antunes and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3433 | Submission Open
Keywords: diagnostic endoscopy; therapeutic endoscopy; gastrointestinal neoplasia; endoscopic mucosal resection; endoscopic submucosal dissection; early cancer; subepithelial lesions
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Dental Implantology: Clinical Updates and Perspectives
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 3432 | Submission Open
Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentistry; perimplantitis; peri-implant soft tissues
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Current Advances in Aortic Valve Stenosis
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3020 | Submission Open
Keywords: valvular heart diseases; aortic stenosis; prevention; diagnosis; management
(This special issue belongs to the Section Cardiology)
Innovation in Hand Surgery
edited by Rocco De Vitis and Marco Passiatore
submission deadline 30 Sep 2025 | 4 articles | Viewed by 2726 | Submission Open
Keywords: hand surgery; hand reconstruction; hand deformities; reconstructive surgery; peripheral nerve surgery; hand tumors; thumb arthritis; wrist arthritis; arthroscopy; prosthesis
(This special issue belongs to the Section Orthopedics)
Geriatric Diseases: Management and Epidemiology
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2697 | Submission Open
Keywords: ageing and health; older care; chronic diseases; preventive health strategies; multidisciplinary approaches; health inequalities; innovation in care; global ageing challenges; epidemiology of ageing; quality of life in older adults
(This special issue belongs to the Section Geriatric Medicine)
Renal Cell Carcinoma: From Diagnostic to Therapy
edited by Ithaar H. Derweesh and Zachary A. Hamilton
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2506 | Submission Open
Keywords: biomarkers; clinical practice patterns; diagnosis; kidney cancer; metastasis; renal cell carcinoma; renal mass; staging; systemic therapy; surveillance
(This special issue belongs to the Section Nephrology & Urology)
Toward Improved Evaluation, Treatment, and Management of Movement Disorders and Cognitive Impairments in People with Cerebral Palsy
edited by Elegast Monbaliu and
submission deadline 30 Sep 2025 | 3 articles | Viewed by 2435 | Submission Open
Keywords: cerebral palsy; movement disorders; cognition; technology; artificial intelligence; wearables; neuroimaging; telehealth
(This special issue belongs to the Section Clinical Neurology)
Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2393 | Submission Open
Keywords: obstructive sleep apnea syndrome; diagnosis; obesity; treatment; CPAP; comorbidities; cardiovascular risk
(This special issue belongs to the Section Respiratory Medicine)
Artificial Intelligence and Eye Disease submission deadline 30 Sep 2025 | 3 articles | Viewed by 2271 | Submission Open
Keywords: Artificial Intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorder
(This special issue belongs to the Section Ophthalmology)
Musculoskeletal Disorders: Clinical Diagnosis, Treatment and Rehabilitation submission deadline 30 Sep 2025 | 2 articles | Viewed by 2107 | Submission Open
Keywords: musculoskeletal disorders; therapeutic exercise; functional evaluation; rehabilitation protocols; musculoskeletal ultrasound; biomechanical aná lisis; quality of life; functional assessment of the musculoskeletal system; strength training; physical therapy; morphofunctional assessment; conservative treatments; range of motion evaluation; randomized controlled trials
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Management of Movement Disorders (Second Edition)
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1901 | Submission Open
Keywords: Parkinson’ s disease; parkinsonism; tremor; tic; dystonia; chorea; athetosis; ballism; myoclonus; ataxia; diagnosis; symptom monitoring; treatments
(This special issue belongs to the Section Clinical Neurology)
Clinical Management for Metabolic Syndrome and Obesity
edited by and Antonio De Arriba-Muñoz
submission deadline 30 Sep 2025 | 3 articles | Viewed by 1890 | Submission Open
Keywords: obesity; metabolic syndrome; estatosis hepatic; diabetes mellitus; children; GLP-1
(This special issue belongs to the Section Endocrinology & Metabolism)
Improving Diagnosis and Treatment of Vestibular Disorder: Latest Advances and Challenges
edited by , and Athanasia Korda
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1844 | Submission Open
Keywords: vestibular system; balance disorders; dizziness; vertigo; vestibular testing; videonystagmography; video head impulse test; vestibular evoked myogenic potentials; vestibular rehabilitation therapy
(This special issue belongs to the Section Otolaryngology)
Multiple Sclerosis and Demyelinating Diseases: Diagnosis, Treatment and Prognosis
edited by Alberto Gajofatto
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1783 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica; MOG-antibody disease; diagnosis; prognosis; treatment
(This special issue belongs to the Section Clinical Neurology)
Clinical and Surgical Updates on Bariatric Surgery submission deadline 30 Sep 2025 | 1 articles | Viewed by 1733 | Submission Open
Keywords: bariatric surgery; morbid obesity; sleeve gastrectomy; gastric bypass; surgical complications; diabetes remission; hypertension remission; hypercholesterolemia remission; GERD; de novo GERD
(This special issue belongs to the Section General Surgery)
The Challenges and Prospects in Cochlear Implantation submission deadline 30 Sep 2025 | 1 articles | Viewed by 1719 | Submission Open
Keywords: cochlear implant; hearing loss; image; modeling; cognition; electrophysiology; AI; big data; interdisciplinary assessment
(This special issue belongs to the Section Otolaryngology)
Advancements in Venous Disease Management: From Conservative to Interventional Treatments
edited by and Chiara Lomazzi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1696 | Submission Open
Keywords: chronic venous disease; varicose veins; venoactive drugs; saphenous vein; venous stent; iliac vein; compression therapy; venous insufficiency
(This special issue belongs to the Section Vascular Medicine)
Clinical Advances in Breast Reconstruction: Treatment and Management
edited by Eric I-Yun Chang
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1377 | Submission Open
Keywords: breast reconstruction; aesthetic breast surgery; robotic surgery; microsurgery; alloplastic breast reconstruction; autologous breast reconstruction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Innovative Approaches to Upper Limb Rehabilitation in Orthopaedics: Advances in Functional Recovery and Pain Management
edited by and Danilo Donati
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1323 | Submission Open
Keywords: upper limb rehabilitation; orthopaedics; musculoskeletal disorders; functional recovery; pain management
(This special issue belongs to the Section Orthopedics)
Experience and New Application in Otolaryngology and Maxillofacial Surgery
edited by Riccardo Nocini
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1217 | Submission Open
Keywords: new surgical techniques; robotics; endoscopy; revascularized free flaps; innovation; 3D surgical planning.
(This special issue belongs to the Section Otolaryngology)
Targeted Diagnosis and Treatment of Coronary Artery Disease: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1204 | Submission Open
Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis
(This special issue belongs to the Section Cardiology)
Innovations in Head and Neck Surgery
edited by and Giovanni Badiali
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1069 | Submission Open
Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation
(This special issue belongs to the Section Otolaryngology)
Advancements in Otitis Media Diagnosis and Management
edited by Sharon Ovnat Tamir and Tal Marom
submission deadline 30 Sep 2025 | 1 articles | Viewed by 883 | Submission Open
Keywords: otitis media; mastoidectomy for cholesteatoma; vaccines; diagnosis; AI; mastoiditis; artificial intelligence; hearing loss
(This special issue belongs to the Section Otolaryngology)
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