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Rehabilitation Strategies for Neurological Disorders: Advances and Insights

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Rehabilitation".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 514

Special Issue Editors


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Guest Editor
Associate Professor, Department of Physical and Rehabilitation Medicine, Carol Davila University of Medicine and Pharmacy, 050451 Bucharest, Romania
Interests: physical medicine and rehabilitation; neurorehabilitation; musculoskeletal ultrasound

E-Mail Website
Guest Editor
Department of Physical and Rehabilitation Medicine, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: physical medicine and rehabilitation; neurorehabilitation; musculoskeletal ultrasound

Special Issue Information

Dear Colleagues,

Neurologic disorders lead to disability through motor, cognitive, and sensory impairments, impacting patients' independence and economic self-sufficiency. The consequences are high social costs and an underestimated psychological impact with low quality of life.

Rehabilitation medicine aims to enable people with impairments and activity limitations to reach and maintain optimal functioning in physical, intellectual, psychological, and/or social domains. There are a wide and heterogeneous range of therapeutic interventions and methodologies in addition to standard medical care. The patient's assessment and the goal-setting process are essential for an individualized neurorehabilitation plan to reduce disability, develop new skills, and adjust behaviors and environments to enhance participation. Increasing evidence suggests that intensive and repeated practice is essential to modify neural organization and facilitate the reacquisition or relearning of motor skills.

In this Special Issue, we welcome authors to submit papers on advanced therapy strategies and concepts for rehabilitation after a neurological disease. These methods aim to boost neuroplasticity and include botulinum toxin, conventional therapy, and advanced technologies, such as robotics, virtual and augmented reality, and artificial intelligence techniques. We need to evaluate these interventions' effectiveness and determine the best timing, intensity, and duration for each rehabilitation method.

Dr. Delia Cinteză
Prof. Dr. Mihai Berteanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurorehabilitation
  • physical medicine
  • virtual reality
  • AI in rehabilitation medicine
  • robotic rehabilitation
  • telerehabilitation
  • advanced technologies
  • upper neuromotor lesions
  • peripheral neuropathies
  • wearable sensor devices
  • assessment
  • goal-setting
  • individual rehabilitation plan

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Published Papers (1 paper)

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Research

19 pages, 930 KiB  
Article
Botulinum Toxin A for Elbow Flexor Spasticity: A Non-Randomized Observational Study of Muscle-Specific Injection Strategies
by Miruna Ioana Săndulescu, Delia Cinteză, Daniela Poenaru, Claudia-Gabriela Potcovaru, Horia Păunescu and Oana Andreia Coman
J. Clin. Med. 2025, 14(11), 3864; https://doi.org/10.3390/jcm14113864 - 30 May 2025
Viewed by 353
Abstract
Introduction: Elbow flexor spasticity is a common and debilitating consequence of stroke, significantly impacting patients’ quality of life. Botulinum toxin A (BoNT-A) injections have emerged as an effective treatment, but the optimal muscle selection strategy remains unclear. This study investigates the impact of [...] Read more.
Introduction: Elbow flexor spasticity is a common and debilitating consequence of stroke, significantly impacting patients’ quality of life. Botulinum toxin A (BoNT-A) injections have emerged as an effective treatment, but the optimal muscle selection strategy remains unclear. This study investigates the impact of different BoNT-A injection strategies targeting specific elbow flexor muscles in post-stroke patients. Materials and Methods: A non-randomized observational study was conducted on 52 participants with upper limb spasticity (pattern IV) following a stroke. Participants were divided into three groups based on the elbow flexor muscles injected with BoNT-A: biceps brachii (n = 15), brachialis (n = 9), and brachialis plus brachioradialis (n = 28). Assessments included spasticity angle, paresis angle, and active supination range of motion (ROM) measured using the Tardieu Scale and goniometry at baseline and at 4-week follow-up. Non-parametric statistical analyses were employed to compare outcomes between groups. Results: While all groups showed a general trend of decreased spasticity and improved motor control, analysis revealed statistically significant differences across the groups at baseline. The brachialis plus brachioradialis group demonstrated the most substantial improvement in paresis angle and active supination ROM. Notably, this group also exhibited greater capacity for the improvement of the paresis angle. The biceps brachii group showed comparable improvements in the paresis angle and the greatest effect on improving passive extension at slow velocity with increasing stroke onset but required higher pronator teres BoNT-A doses overall. Discussion: These findings suggest that individualized muscle selection strategies are crucial in BoNT-A treatment for elbow flexor spasticity. The superior outcomes observed in the brachialis plus brachioradialis group may be attributed to the synergistic action of these muscles in elbow flexion and forearm positioning. The higher pronator teres BoNT-A doses required in the biceps brachii group may reflect compensatory mechanisms or differences in muscle fiber recruitment patterns. Conclusions: Combining brachialis and brachioradialis muscles in BoNT-A injections appears to offer superior benefits for supination and motor control in post-stroke patients with elbow flexor spasticity, particularly those with significant elbow flexion and pronation. Full article
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