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Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 296

Special Issue Editor


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Guest Editor
Department of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea
Interests: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; postoperative analgesia; chronic pain interventions; patient satisfaction; multimodal analgesia; opioid-sparing strategies; non-opioid analgesics

Special Issue Information

Dear Colleagues,

Regional anesthesia has firmly established itself as an integral element of modern pain management strategies, demonstrating considerable clinical efficacy through enhanced patient comfort, significant reductions in opioid reliance, and notable improvements in postoperative outcomes and recovery processes. Despite these advancements, ongoing clinical and technical challenges persist, particularly regarding the optimization of procedural techniques, the accuracy of ultrasound-guided interventions, the long-term efficacy of regional anesthetics, and the assessment and management of associated complications.

This Special Issue, entitled "Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction", is designed to gather high-quality original research articles and detailed systematic reviews that directly address these pivotal concerns. We particularly encourage submissions exploring advanced ultrasound-guided nerve blocks, innovative fascial plane techniques, postoperative and chronic pain management interventions, comprehensive multimodal analgesia protocols, strategies for opioid minimization, and emerging applications of non-opioid analgesics.

By integrating current evidence-based practices, presenting pioneering methodologies, and highlighting evolving clinical paradigms, this Issue aims to enrich clinical knowledge, facilitate informed professional discussion, and inspire continuous improvement in patient-centered pain management outcomes.

We warmly welcome your expert contributions to this critically important field.

Dr. Min Suk Chae
Guest Editor

Manuscript Submission Information

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Keywords

  • regional anesthesia
  • pain management
  • ultrasound-guided nerve blocks
  • fascial plane blocks
  • multimodal analgesia
  • postoperative analgesia
  • chronic pain management
  • opioid-sparing strategies
  • non-opioid analgesics
  • patient satisfaction
  • anesthesia techniques
  • perioperative care
  • pain interventions
  • nerve block techniques
  • clinical outcomes

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Published Papers (1 paper)

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Review

28 pages, 1574 KB  
Review
Hydrogel-Based Delivery Systems for Non-Opioid Analgesics: Advances, Challenges, and Clinical Prospects
by Kyung Kwan Lee, Wonwoo Jeong and Minsuk Chae
J. Clin. Med. 2025, 14(21), 7768; https://doi.org/10.3390/jcm14217768 (registering DOI) - 1 Nov 2025
Abstract
This review focuses on hydrogel-based systems specifically designed for non-opioid analgesics, aiming to improve efficacy, safety, and translational applicability. The opioid crisis has intensified the need for safer and more effective alternatives in pain management. Non-opioid analgesics including NSAIDs, acetaminophen, gabapentinoids, antidepressants, anticonvulsants, [...] Read more.
This review focuses on hydrogel-based systems specifically designed for non-opioid analgesics, aiming to improve efficacy, safety, and translational applicability. The opioid crisis has intensified the need for safer and more effective alternatives in pain management. Non-opioid analgesics including NSAIDs, acetaminophen, gabapentinoids, antidepressants, anticonvulsants, NMDA receptor antagonists, topical agents, and cannabinoids offer promising options but are limited by rapid clearance, short half-lives, and off-target effects. Hydrogel-based drug delivery systems present a novel solution by enabling controlled, localized, and sustained release of analgesics, thus improving therapeutic efficacy and minimizing systemic toxicity. Advances in stimulus-responsive, self-healing, mechanically robust, and hybrid or nanocomposite hydrogels have broadened their biomedical applications and clinical relevance. This narrative review summarizes key hydrogel technologies and their integration with non-opioid analgesic agents. We explore encapsulation strategies, drug release mechanisms, and emerging clinical data, while also addressing critical challenges such as biocompatibility, mechanical durability, and translational scalability. Interdisciplinary collaboration between material scientists, clinicians, and regulatory experts is essential to advance hydrogel-based therapies from bench to bedside. Overall, hydrogel platforms hold transformative potential in optimizing non-opioid analgesic delivery and redefining the future of pain management. Full article
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