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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug-Related Problems: Clinical Pharmacy and Safety of Pharmacotherapy

edited by

Mariola Drozd

and

Jakub Pawlikowski

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1283 | Submission Open

Keywords: adverse drug reaction; drug-related problems; drug formulation technology; safety of pharmacotherapy; clinical pharmacy; pharmaceutical care; pharmacology

(This special issue belongs to the Section Pharmacology)

Bariatric Surgery: Challenges and Future Trends

edited by Hugo Santos-Sousa

submission deadline 15 Feb 2026 | 2 articles | Viewed by 1275 | Submission Open

Keywords: obesity; metabolic and bariatric surgery; sleeve gastrectomy; metabolic syndrome; novel surgical procedures; Nissen-sleeve fundoplication; Roux-en-Y gastric bypass distalization; single-anastomosis procedures

(This special issue belongs to the Section General Surgery)

New Insights in Neonatal Intensive Care

edited by

Benjamim Ficial

Leonardo Gottin

and Martina Ciarcià

submission deadline 15 Feb 2026 | Viewed by 764 | Submission Open

Keywords: neonatal intensive care; neonatal diseases; critically ill infants; premature infants; neonatal care; intensive care medicine

(This special issue belongs to the Section Clinical Pediatrics)

Advances in Traumatic Brain Injury: Causes and Recovery

edited by Antonio Bonora

submission deadline 15 Feb 2026 | Viewed by 243 | Submission Open

Keywords: mild traumatic brain injury; TBI; brain injuries; neuroimaging; rehabilitation

(This special issue belongs to the Section Brain Injury)

Kidney Transplantation: Current Challenges and Future Perspectives: 2nd Edition

edited by Alberto Piana and Angelo Territo

submission deadline 15 Feb 2026 | Viewed by 153 | Submission Open

Keywords: kidney transplantation; urologic cancers; organ preservation; surgical challenges; donor selection; long-term outcomes; complications; post-transplant care; technology

(This special issue belongs to the Section Nephrology & Urology)

Recent Advances in Refractive Surgery and Intraocular Lens Implantation

edited by Antonio Leccisotti

submission deadline 15 Feb 2026 | Viewed by 145 | Submission Open

Keywords: refractive surgery; intraocular lens implantation; keratectomy; cornea; ocular surgery; optical coherence tomography; laser surgery; KLEx (keratorefractive lenticule extraction); femtolasik

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition

edited by

Eleonora M.C. Trecca

and

Andrea Albera

submission deadline 15 Feb 2026 | Viewed by 113 | Submission Open

Keywords: middle ear; inner ear; endoscopic ear surgery; cholesteatoma; Meniè re’ s disease; hearing loss; robotic surgery; oto-sclerosis

(This special issue belongs to the Section Otolaryngology)

State of the Art in Bladder Cancer: Diagnostics and Treatment Strategies

edited by

Angelo Porreca

submission deadline 15 Feb 2026 | Viewed by 99 | Submission Open

Keywords: bladder cancer; photodynamic diagnosis (PDD); bladder-sparing strategies; robotic-assisted surgery; single-port robotic cystectomy; older patients; immunotherapy; intravesical therapy; bladder preservation; minimally invasive urology; advanced bladder cancer; diagnostic innovation

(This special issue belongs to the Section Nephrology & Urology)

Clinical Perspectives in Amyotrophic Lateral Sclerosis: Diagnosis, Management and Future Opportunities

edited by

Matthias Boentert

submission deadline 15 Feb 2026 | Viewed by 93 | Submission Open

Keywords: amyotrophic lateral sclerosis; early diagnosis; neuroimaging; biomarkers; treatment

(This special issue belongs to the Section Clinical Neurology)

Eosinophilic Esophagitis: Clinical Advances in Diagnosis, Treatment, and Monitoring

edited by Pierfrancesco Visaggi, Edoardo Vincenzo Savarino and

Nicola De Bortoli

submission deadline 18 Feb 2026 | 4 articles | Viewed by 4972 | Submission Open

Keywords: eosinophilic esophagitis (EoE); diagnosis ; treatment ; monitoring; disease assessment; precision medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Endocrine Malignancies: Current Surgical Therapeutic Approaches: 2nd Edition

edited by

Mariarita Tarallo

Enrico Fiori

and Marco Bononi

submission deadline 18 Feb 2026 | 4 articles | Viewed by 4768 | Submission Open

Keywords: endocrine malignancies; thyroid cancer; adrenocortical cancer; parathyroid; men

(This special issue belongs to the Section Endocrinology & Metabolism)

Traumatic Brain Injury: Emergency Management, Prevention of Secondary Injury, and Rehabilitation

edited by

Katja E. Wartenberg

and Lori Shutter

submission deadline 20 Feb 2026 | 5 articles | Viewed by 17255 | Submission Open

Keywords: traumatic brain injury; neuromonitoring; neurocritical care; neurorehabilitation; secondary injury; outcome; prognostication

(This special issue belongs to the Section Brain Injury)

Sepsis: Current Updates and Perspectives

edited by

Ecaterina Scarlatescu

submission deadline 20 Feb 2026 | 8 articles | Viewed by 16712 | Submission Open

Keywords: sepsis biomarkers; diagnostic tools; cytokines; inflammation; infection; antibiotherapy; blood purification; novel therapies

(This special issue belongs to the Section Intensive Care)

Recent Developments in Gynecological Endocrinology

edited by

Błażej Męczekalski

submission deadline 20 Feb 2026 | 8 articles | Viewed by 15079 | Submission Open

Keywords: amenorrhea; puberty; PCOS; premature ovarian insufficiency; endometriosis; infertility; pregnancy; hormones; menopause

(This special issue belongs to the Section Obstetrics & Gynecology)

Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions

edited by Mauro Zaccarelli and

Alessandra Latini

submission deadline 20 Feb 2026 | 5 articles | Viewed by 14592 | Submission Open

Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex

(This special issue belongs to the Section Infectious Diseases)

Endodontic and Periodontal Medicine: Systemic Implications of Oral Infections

edited by

Juan J. Segura-Egea

and

Daniel Cabanillas-Balsera

submission deadline 20 Feb 2026 | 9 articles | Viewed by 12770 | Submission Open

Keywords: dentistry; endodontics; apical periodontitis; endodontic medicine; periodontal disease; periodontal medicine; pulpitis; systemic diseases; root canal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Blood Disorders: Diagnosis, Management, and Future Opportunities

edited by

Cristina Panuzzo

and

Barbara Pergolizzi

submission deadline 20 Feb 2026 | 4 articles | Viewed by 12021 | Submission Open

Keywords: blood disorders; biomarkers; personalized medicine; diagnosis; NGS; metabolomics; digital droplet PCR (ddPCR)

(This special issue belongs to the Section Hematology)

Pediatric Critical Care: Clinical Recognition, Management, and Outcomes

edited by Janet Hume

submission deadline 20 Feb 2026 | 6 articles | Viewed by 11926 | Submission Open

Keywords: pediatric critical care medicine; sepsis; pediatric acute respiratory distress syndrome; mechanical ventilation; renal replacement therapy; chronic critical illness; post-intensive care syndrome

(This special issue belongs to the Section Clinical Pediatrics)

Cystic Fibrosis: Diagnosis and Treatment

edited by Corrado Tagliati and Gian Marco Giuseppetti

submission deadline 20 Feb 2026 | 5 articles | Viewed by 11330 | Submission Open

Keywords: cystic fibrosis; diagnosis; treatment; management

(This special issue belongs to the Section Respiratory Medicine)

Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management

edited by

Kornelia Zaręba

Aneta Słabuszewska-Jóźwiak

and Mohamed Ahmed Mostafa Aboellail

submission deadline 20 Feb 2026 | 4 articles | Viewed by 8926 | Submission Open

Keywords: preeclampsia; pregnancy complications; early intervention; diagnosis of pregnancy complications; management of pregnancy complications; sexual dysfunctions in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Orthopedic Surgery: Recent Advances and Prospects

edited by Mitchell K. Ng

submission deadline 20 Feb 2026 | 4 articles | Viewed by 8600 | Submission Open

Keywords: orthopedic surgery; clinical updates; joint reconstruction; spine surgery; trauma; elective surgery; peri-operative management

(This special issue belongs to the Section Orthopedics)

Neuroendocrine Tumors: Challenges and Future Perspectives (Second Edition)

edited by

Anna La Salvia

and

Giuseppe Lamberti

submission deadline 20 Feb 2026 | 5 articles | Viewed by 8360 | Submission Open

Keywords: neuroendocrine tumors; clinical challenges; innovative biomarkers; novel agents; personalized oncology

(This special issue belongs to the Section Oncology)

Management of Pituitary Tumors: Current and Future Treatment Options—2nd Edition

edited by

Amit Akirov

submission deadline 20 Feb 2026 | 6 articles | Viewed by 8234 | Submission Open

Keywords: pituitary; cushing syndrome; acromegaly; prolactinoma; non-functioning pituitary adenoma; hypopituitarism; hypophysitis

(This special issue belongs to the Section Endocrinology & Metabolism)

Targeted Treatment in Chronic Inflammatory Arthritis

edited by

Cinzia Rotondo

Simone Parisi

and Simone Perniola

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7539 | Submission Open

Keywords: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; spondyloarthritis; disease-modifying antirheumatic drugs (DMARDs); personalized medicine; immunomodulatory therapies; patient outcomes; combination therapies

(This special issue belongs to the Section Immunology & Rheumatology)

Navigating Pregnancy and Its Complications: Challenges and Innovations in Maternal–Fetal Medicine

edited by

Nikolaos Machairiotis

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7437 | Submission Open

Keywords: pregnancy; obstetrics; diabetes; high risk; preeclampsia; labor; delivery; hypertension; hemorrhage; embryo; screening

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Updates on Hereditary Hemorrhagic Telangiectasia (HHT) and Other Vascular Diseases

edited by Tamás Major

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5727 | Submission Open

Keywords: hereditary hemorrhagic telangiectasia (HHT); arteriovenous malformations; embolization; VEGF; capillary malformation-arteriovenous malformation

(This special issue belongs to the Section Vascular Medicine)

Optimizing Present and Future Therapeutic Choices for Treatment and Management of Chronic Inflammatory Bowel Diseases—2nd Edition

edited by

Lorenzo Bertani

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5315 | Submission Open

Keywords: Inflammatory Bowel Diseases(IBD); JAK inhibitors; mucosal healing

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Immunotherapy of Cancer

edited by

Jessica Chacon

and

Shrikanth Gadad

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4987 | Submission Open

Keywords: immunotherapy; immunology; cancer; oncology; tumor immune microenvironment; artificial intelligence; immune-related adverse events

(This special issue belongs to the Section Oncology)

Gastrointestinal Diseases: Clinical Challenges and Management

edited by Anusha Shirwaikar Thomas and

Yinghong Wang

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4979 | Submission Open

Keywords: GI bleed; nutrition; obstructive jaundice; drug-induced liver injury; GI motility; clostridium difficile infection; large bowel obstruction; colon cancer prevention and surveillance

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention

edited by

Justyna Wyszyńska

and

Piotr Matłosz

submission deadline 20 Feb 2026 | 5 articles | Viewed by 4930 | Submission Open

Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits

(This special issue belongs to the Section Clinical Rehabilitation)

Novel Therapeutic Targets with Inflammatory Bowel Diseases

edited by Konstantinos H. Katsanos and

Fotios S. Fousekis

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4869 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; colorectal; intestinal bowel disease; mucosal im-munology; molecular endoscopy; fibrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Interstitial Lung Disease: From Diagnosis to Treatment

edited by

Takeshi Saraya

and Tomohisa Baba

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4527 | Submission Open

Keywords: interstitial pneumonia; diagnosis; virus infection; collagen vascular disease-related interstitial pneumonia; differen-tial diagnosis; lung sounds

(This special issue belongs to the Section Respiratory Medicine)

Updates on Lumbar Spine Surgery for Degenerative Diseases

edited by

Se-Jun Park

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4494 | Submission Open

Keywords: degenerative disease; lumbar spine surgery; fusion; decompressive surgery; sagittal alignment; complications; outcomes

(This special issue belongs to the Section Orthopedics)

Non-Invasive Respiratory Support: Current Insights and Future Directions

edited by Giovanni Misseri and

Cesare Gregoretti

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4469 | Submission Open

Keywords: respiratory failure; high-flow nasal cannula (HFNC); noninvasive ventilation (NIV); noninvasive positive pressure ventilation (NPPV); hypoxia; perioperative care; weaning; ICU; respiratory care; respiratory physiology; pneumology; home-care ventilation; artificial intelligence; personalized medicine

(This special issue belongs to the Section Respiratory Medicine)

Cardiopulmonary Resuscitation in Emergency Care Units

edited by

Stavros Dimopoulos

and

Christos Kourek

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4351 | Submission Open

Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes

(This special issue belongs to the Section Emergency Medicine)

Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management

edited by

Adrian Boicean

and

Cristian Ichim

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4164 | Submission Open

Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Gastrointestinal Inflammation

edited by

Ivana Jukic

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4121 | Submission Open

Keywords: Helicobacter pylori; antibiotic resistance; COVID-19 pandemic; post-COVID era; inflammatory bowel diseases; acute gastrointestinal infections; SARS-COV-2 infection; celiac disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Innovations in Perioperative Anesthesia: Advancing Non-Operating Room Anesthesia (NORA) and Regional Techniques

edited by Francesco Coppolino and

Vincenzo Pota

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3488 | Submission Open

Keywords: perioperative medicine; non-operating room anesthesia (NORA); ultrasound-guided regional anesthesia; fascial plane blocks; postoperative pain management

(This special issue belongs to the Section Anesthesiology)

Clinical Trends in Cardiomyopathy

edited by Giulia Iannaccone

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3445 | Submission Open

Keywords: cardiomyopathy; genetics; treatment; targeted therapy; prognosis; long-term follow up

(This special issue belongs to the Section Cardiology)

Intraocular Lenses for Cataract Surgery: Clinical Advances and Perspectives

edited by Choul Yong Park

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3440 | Submission Open

Keywords: cataract surgery; intraocular lens; IOL formula; optic; complication; presbyopia; refractive

(This special issue belongs to the Section Ophthalmology)

Neurosurgery: Recent Advances and New Perspectives in Skull Base Approaches

edited by Sèbastien Froelich and Matteo De Simone

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3425 | Submission Open

Keywords: skull base; neuroanatomy; tumors; augmented reality; ETOA; EEA; exoscopy; endoscopy; multi-portal approaches

(This special issue belongs to the Section Clinical Neurology)

Recent Developments in Hearing and Balance Disorders: 2nd Edition

edited by

Juan Carlos Amor-Dorado

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3408 | Submission Open

Keywords: ear; otology; audiology; hearing disorders; deafness; hearing loss; autoimmunity; ENT; inflammation; vertigo; imbalance

(This special issue belongs to the Section Otolaryngology)

Innovative Approaches to the Challenges of Neurodegenerative Disease

edited by Brian T. Bicknell and

Ann Liebert

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3281 | Submission Open

Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Trauma and Emergency Medicine

edited by Yong-Soo Cho and Hyun Ho Ryu

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3214 | Submission Open

Keywords: emergency medicine; epidemiology; cardiovascular disease

(This special issue belongs to the Section Emergency Medicine)

Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes

edited by Filippo Carannante and Leandro Siragusa

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2995 | Submission Open

Keywords: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology

(This special issue belongs to the Section General Surgery)

Pain Management: Current Challenges and Future Prospects

edited by Gian Marco Petroni

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2967 | Submission Open

Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs

(This special issue belongs to the Section Anesthesiology)

Clinical Progress of Spine Surgery

edited by

Edoardo Mazzucchi

and Gianluca Vadalà

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2926 | Submission Open

Keywords: spine surgery; rehabilitation; robotic surgery; spinal endoscopy; spinal tumor; back pain; minimally invasive surgery; spinal fusion

(This special issue belongs to the Section Clinical Neurology)

Acute Kidney Events in Intensive Care Patients

edited by Kada Klouche

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2852 | Submission Open

Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; bi-omarkers

(This special issue belongs to the Section Intensive Care)

State of the Art in Invasive Vascular Interventions (Second Edition)

edited by

Edit Dósa

and Luca Mezzetto

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2825 | Submission Open

Keywords: coronary artery interventions; non-coronary artery cardiac interventions; open surgical cardiac procedures; endo-vascular interventions; open surgical vascular procedures

(This special issue belongs to the Section Vascular Medicine)

Kidney Transplantation: State of the Art Knowledge

edited by

Georgios Koimtzis

, Georgios Geropoulos and Kyriakos Psarras

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2705 | Submission Open

Keywords: kidney transplantation; end-stage renal disease; immunosuppression; organ donation; graft survival; graft rejection

(This special issue belongs to the Section Nephrology & Urology)

Displaying special issue 651-700 on page 14 of 31.

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