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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Updates on Metabolic and Bariatric Surgery
edited by Maria-Jose Barahona
submission deadline 27 Dec 2025 | 1 articles | Viewed by 1558
Keywords: obesity; bariatric surgery; metabolic surgery; weight loss; obesity treatment; metabolic disorders
(This special issue belongs to the Section General Surgery)
Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions
edited by Roberto Scacciavillani and Gemma Pelargonio
submission deadline 28 Dec 2025 | 7 articles | Viewed by 6622 | Submission Open
Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing
(This special issue belongs to the Section Cardiology)
Lung Transplantation: Current Strategies and Future Directions
edited by Omer Senbaklavaci and György Lang
submission deadline 28 Dec 2025 | 1 articles | Viewed by 1849 | Submission Open
Keywords: lung transplantation; graft optimization; immunosuppression; artificial lung; xenotransplantation; end-stage lung disease; donor lung preservation; chronic lung allograft dysfunction
(This special issue belongs to the Section Respiratory Medicine)
Managements of Venous Thromboembolism submission deadline 29 Dec 2025 | 4 articles | Viewed by 3195 | Submission Open
Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine
(This special issue belongs to the Section Vascular Medicine)
Pediatric Neurosurgery: Clinical Advances in Diagnostics and Perioperative Management
edited by Kara Leigh Krajewski and Ulrich-Wilhelm Thomale
submission deadline 29 Dec 2025 | 1 articles | Viewed by 1850 | Submission Open
Keywords: rapid sequence MRI; intraoperative MRI; perioperative management; neurocritical care; patient selection; M&M conferences; surgical team; rehabilitation
(This special issue belongs to the Section Clinical Pediatrics)
Current Concepts and Clinical Application of Echocardiography
edited by
submission deadline 29 Dec 2025 | Viewed by 205 | Submission Open
Keywords: echocardiography; clinical echocardiography; advanced echocardiography; cardiovascular disease; clinical cardiology
(This special issue belongs to the Section Cardiology)
Treatment of Atopic Dermatitis
edited by and Ricardo Ruíz-Villaverde
submission deadline 30 Dec 2025 | 7 articles | Viewed by 23445 | Submission Open
Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment
(This special issue belongs to the Section Dermatology)
Chronic Pain: Non-Pharmacological Treatments and Rehabilitation Strategies
edited by Matteo Ponzano
submission deadline 30 Dec 2025 | 8 articles | Viewed by 20330 | Submission Open
Keywords: pain; neuropathies; musculoskeletal health; biopsychosocial management; physical therapy; cognitive behavioral therapies
(This special issue belongs to the Section Clinical Rehabilitation)
Current Challenges in Inflammatory Bowel Diseases submission deadline 30 Dec 2025 | 4 articles | Viewed by 10322 | Submission Open
Keywords: ulcerative colitis; Chron’ s disease; inflammatory bowel disease; colitis-associated cancer; novel pharmaceutics
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The State of Breast Reconstruction: From Surgical Methods to Patient-Reported Outcomes
edited by Geoffroy C. Sisk
submission deadline 30 Dec 2025 | 2 articles | Viewed by 6974 | Submission Open
Keywords: breast reconstruction; implant based; autologous tissue; oncoplastic; breast cancer reconstruction; patient-reported outcomes; acellular dermal matrix; prepectoral; lymphedema; microsurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Recent Advances in Glaucoma Management
edited by Bogomil Voykov
submission deadline 30 Dec 2025 | 3 articles | Viewed by 5157 | Submission Open
Keywords: glaucoma; MIGS; microinvasive glaucoma surgery; quality of life; sustained-release drugs; wound healing modula-tion; intraocular pressure; intraocular pressure-lowering medication; microstent-supported bleb surgery; MIBS; neuroprotection
(This special issue belongs to the Section Ophthalmology)
Augmented and Artificial Intelligence in Ophthalmology
edited by Tina Felfeli, Edsel B. Ing, David Jose Mathew and Michael Balas
submission deadline 30 Dec 2025 | 2 articles | Viewed by 3029 | Submission Open
Keywords: artificial intelligence; ophthalmology; eye health; vision; teleophthalmology
(This special issue belongs to the Section Ophthalmology)
Inflammatory Bowel Disease: From Diagnosis to Treatment—2nd Edition
edited by Laura Maria Minordi and Daniela Pugliese
submission deadline 30 Dec 2025 | 3 articles | Viewed by 2889 | Submission Open
Keywords: Crohn’ s disease; ulcerative colitis; imaging; endoscopy; complications; advanced therapies; surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Shoulder Arthroplasty: Clinical Advances and Future Perspectives
edited by Vani J. Sabesan
submission deadline 30 Dec 2025 | 2 articles | Viewed by 1865 | Submission Open
Keywords: shoulder arthroplasty; reverse shoulder arthroplasty; perioperative optimization; multimodal pain management; rehabilitation protocols; outpatient shoulder arthroplasty; implant longevity; complication management; disparities in outcomes
(This special issue belongs to the Section Orthopedics)
Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1541 | Submission Open
Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis
(This special issue belongs to the Section Immunology & Rheumatology)
State of the Art in Management of Aortic Aneurysm in Vascular Surgery
edited by Rana O. Afifi and Eanas Yassa
submission deadline 30 Dec 2025 | 3 articles | Viewed by 1485 | Submission Open
Keywords: aortic dissection; complex aortic surgery; endovascular aortic repair; aortic imaging; aortic aneurysm
(This special issue belongs to the Section Vascular Medicine)
Innovations and Challenges in Cardiovascular Surgery
edited by Marc Leon
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1053 | Submission Open
Keywords: cardiovascular surgery; minimally invasive surgery; robotic surgery; hybrid; 3D printing; artificial intelligence; mechanical circulatory support; heart transplantation; valve disease; aortic dissection; ischemic heart disease; heart failure
(This special issue belongs to the Section Cardiovascular Medicine)
Current and Emerging Treatment Options in Colorectal Cancer
edited by Michael Osseis
submission deadline 30 Dec 2025 | 1 articles | Viewed by 490 | Submission Open
Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Interventional Cardiology: Recent Developments and Future Challenges
edited by and George Kassimis
submission deadline 30 Dec 2025 | Viewed by 302 | Submission Open
Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS; OCT); coronary physiology (FFR; iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)
(This special issue belongs to the Section Cardiology)
Clinical Advances in Antiphospholipid Syndrome (APS)
edited by
submission deadline 30 Dec 2025 | Viewed by 221 | Submission Open
Keywords: thrombosis; pregnancy; antiphospholipid syndrome; lupus anticoagulant; antiphospholipid antibodies
(This special issue belongs to the Section Immunology & Rheumatology)
Plastic and Reconstructive Surgery of the Face: Chances and Challenges
edited by and Bogdan Andrei Suciu
submission deadline 30 Dec 2025 | Viewed by 220 | Submission Open
Keywords: facial plastic surgery; facial reconstruction procedures; tissue regeneration; esthetic facial procedures; digital imaging and customization; biomaterials in reconstructive surgery; flap surgery innovations; microsurgical precision techniques
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice
edited by Mattia Algeri
submission deadline 30 Dec 2025 | Viewed by 194 | Submission Open
Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship
(This special issue belongs to the Section Hematology)
Cutting-Edge Technologies and Unconventional Therapies in Heart Failure
edited by and Pablo Díez-Villanueva
submission deadline 30 Dec 2025 | Viewed by 163 | Submission Open
Keywords: heart failure; new technologies; artificial intelligence; treatment; advanced heart failure
(This special issue belongs to the Section Cardiology)
Challenges and Opportunities in Colorectal Cancer
edited by
submission deadline 30 Dec 2025 | Viewed by 141 | Submission Open
Keywords: colorectal cancer; screening; staging; treatment of colorectal cancer (CRC); high-risk patients; fecal occult testing; colonoscopy; lynch syndrome
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Diagnosis and Treatment of Amyloidosis
edited by Michael Rosenzweig
submission deadline 31 Dec 2025 | 9 articles | Viewed by 23589 | Submission Open
Keywords: amyloidosis; transthyretin (TTR); autologous stem cell transplantation (ASCT); chemotherapy; immunotherapy; cardiomyopathy; nephropathy; neuropathy
(This special issue belongs to the Section Cardiology)
Symptoms and Treatment of Parkinson’s Disease
edited by and Nikolaos Papagiannakis
submission deadline 31 Dec 2025 | 6 articles | Viewed by 21408 | Submission Open
Keywords: Parkinson’ s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies
(This special issue belongs to the Section Clinical Neurology)
Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions
edited by Cosmin Sinescu, and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 21396 | Submission Open
Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Management of Prosthetic Joint Infection (PJI)
edited by Daniel Pérez-Prieto
submission deadline 31 Dec 2025 | 7 articles | Viewed by 13748 | Submission Open
Keywords: prosthetic joint infection; debridement; biofilm; wound healing; multidisciplinary team; osteomyelitis
(This special issue belongs to the Section Orthopedics)
Challenges in the Field of Psycho-Oncology: Insights from Research
edited by , , Tânia Brandão and Ricardo Teixeira
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7265 | Submission Open
Keywords: cancer; psycho-oncology; survivorship care; psychological distress; quality of life; sustainable development goals; global health; health disparities
(This special issue belongs to the Section Oncology)
New Trends and Challenges in Critical Care Management
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5247 | Submission Open
Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19
(This special issue belongs to the Section Intensive Care)
Rare Respiratory Diseases: A Personal and a Public Health Problem: 3rd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4509 | Submission Open
Keywords: rare diseases; rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis; lymphangioleiomyomatosis; interstitial lung diseases; pulmonary arterial hypertension
(This special issue belongs to the Section Respiratory Medicine)
Acute Kidney Injury: Latest Advances and Prospects
edited by and Kianoush Kashani
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4272 | Submission Open
Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Knee and Hip Arthroplasty
edited by Amarildo Smakaj and Elena Gasbarra
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4139 | Submission Open
Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening
(This special issue belongs to the Section Orthopedics)
Clinical Therapeutic Advances in Bone Fractures
edited by Simon Hackl and Eva Simone Steinhausen
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3541 | Submission Open
Keywords: stem cells; biomechanics; fracture fixation; orthobiologics; rehabilitation; personalized medicine; 3D printing; im-plant coating; nonunion; fracture-related infection
(This special issue belongs to the Section Orthopedics)
Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health
edited by and Anne-Marie Iselin
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2794 | Submission Open
Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms
(This special issue belongs to the Section Mental Health)
Pregnancy Complications and Maternal-Perinatal Outcomes
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2273 | Submission Open
Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions
edited by Pietro C. Dattolo and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1839 | Submission Open
Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Prenatal Diagnosis
edited by Valentina D'Ambrosio
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1742 | Submission Open
Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies
(This special issue belongs to the Section Obstetrics & Gynecology)
Novel Advanced Imaging in Cardiology: Current Status and Future Directions
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1670 | Submission Open
Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics
(This special issue belongs to the Section Cardiovascular Medicine)
Children and Adolescent Mood Disorders: Risks and Treatment submission deadline 31 Dec 2025 | Viewed by 1564 | Submission Open
Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs
(This special issue belongs to the Section Mental Health)
Recent Progress and Future Directions in Orthopedic Oncology
edited by and Carmine Zoccali
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1031 | Submission Open
Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology
(This special issue belongs to the Section Orthopedics)
Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction submission deadline 31 Dec 2025 | 1 articles | Viewed by 801 | Submission Open
Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations
(This special issue belongs to the Section Ophthalmology)
Advances in Gene Therapy for Retinal Diseases
edited by Tahreem Aman Mir
submission deadline 31 Dec 2025 | Viewed by 244 | Submission Open
Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy
(This special issue belongs to the Section Ophthalmology)
Clinical Trends in Diagnostic Radiology
edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen
submission deadline 31 Dec 2025 | Viewed by 224 | Submission Open
Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Progress in the Multimodal Treatment of Pancreatic Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 171 | Submission Open
Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management
edited by Adam Gwozdz
submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open
Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment
edited by
submission deadline 5 Jan 2026 | 1 articles | Viewed by 3199 | Submission Open
Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted
(This special issue belongs to the Section Mental Health)
Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition
edited by
submission deadline 9 Jan 2026 | 5 articles | Viewed by 4027 | Submission Open
Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Pancreatobiliary Diseases
edited by
submission deadline 9 Jan 2026 | 1 articles | Viewed by 1218 | Submission Open
Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention
edited by Anbukarasi Maran and Kevin Croce
submission deadline 9 Jan 2026 | Viewed by 148 | Submission Open
Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology  
(This special issue belongs to the Section Cardiovascular Medicine)
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