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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era submission deadline 30 Nov 2025 | 4 articles | Viewed by 8624 | Submission Open
Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology
(This special issue belongs to the Section Cardiovascular Medicine)
Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 7341 | Submission Open
Keywords: head and neck oncology; free flaps; oral surgery; malformative surgery; traumatology; endoscopy; preprosthetic surgery; reconstructive surgery; vascular malformations; osteonecrosis
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Insights into Cardiovascular and Minimally Invasive Cardiac Surgery
edited by Parwis Massoudy and Hilmar C. Dörge
submission deadline 30 Nov 2025 | 4 articles | Viewed by 6843 | Submission Open
Keywords: coronary artery bypass grafting; aortic valve surgery; mitral valve surgery; aortic surgery; minimally invasive cardiac surgery
(This special issue belongs to the Section Cardiology)
Clinical Advances in Therapy of Trauma and Surgical Critical Care
edited by Rabail Chaudhry and George W. Williams
submission deadline 30 Nov 2025 | 2 articles | Viewed by 6824 | Submission Open
Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations
(This special issue belongs to the Section Intensive Care)
Recent Progress in Rehabilitation Medicine—3rd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6414 | Submission Open
Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life
(This special issue belongs to the Section Clinical Rehabilitation)
Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches
edited by Elisabeth M.J.P. Mouws and
submission deadline 30 Nov 2025 | 5 articles | Viewed by 5955 | Submission Open
Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options
(This special issue belongs to the Section Cardiology)
Ischemic Stroke: Diagnosis and Treatment submission deadline 30 Nov 2025 | 4 articles | Viewed by 5897 | Submission Open
Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy
(This special issue belongs to the Section Clinical Neurology)
Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases
edited by Sotiria Palioura, Carolina L. Mercado and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4401 | Submission Open
Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques
(This special issue belongs to the Section Ophthalmology)
Clinical Research and Personalized Medicine in Inflammatory Bowel Disease
edited by and Loris Riccardo Lopetuso
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3228 | Submission Open
Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2879 | Submission Open
Keywords: heart; lung; kidney; liver; bone; brain
(This special issue belongs to the Section Clinical Rehabilitation)
Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition
edited by Nikos Nikolettos and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2295 | Submission Open
Keywords: assisted reproduction technology (ART); infertility; treatment; reproduction; IVF
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Clinical Updates on Prosthodontics
edited by and Carla Fons-Badal
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2246 | Submission Open
Keywords: dental prosthesis; dental implants; gingival treatment; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances of Breast Surgery and Reconstruction
edited by and Emanuele Cigna
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1903 | Submission Open
Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Cirrhosis and Its Complications: Prognosis and Clinical Management
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1865 | Submission Open
Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Aspects of Endocrine Care: From Patient-Centred Management of Endocrine Diseases to Guidelines Standards submission deadline 30 Nov 2025 | 2 articles | Viewed by 1622 | Submission Open
Keywords: endocrine tumour; hormone; biomarker; neuroendocrine tumour; thyroidectomy; parathyroidectomy; bone; ad-renal gland; osteoporosis; pituitary gland; autoimmune; antibody; clinical study; computed tomography
(This special issue belongs to the Section Endocrinology & Metabolism)
Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer
edited by Bhaumik Patel
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1429 | Submission Open
Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates on Rheumatoid Arthritis: 2nd Edition
edited by Francesca Bandinelli
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1401 | Submission Open
Keywords: rheumatoid arthritis; rheumatology; treatment; diagnosis; biomarkers; rheumatic disease
(This special issue belongs to the Section Immunology & Rheumatology)
Orthodontics: State of the Art and Prospects
edited by Beatriz Tarazona-Álvarez and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1317 | Submission Open
Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Application of Knee Arthroscopy
edited by and Alessandro Carrozzo
submission deadline 30 Nov 2025 | 3 articles | Viewed by 1299 | Submission Open
Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation
(This special issue belongs to the Section Orthopedics)
Innovative Technologies and Approaches in Eye Disease Management and Refractive Surgery
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1243 | Submission Open
Keywords: multifocal intraocular lenses; femtosecond lasers; artificial intelligence; imaging; eye surgery; refractive surgery
(This special issue belongs to the Section Ophthalmology)
Thoracic Surgery Between Tradition and Innovations
edited by Jacopo Vannucci
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1201 | Submission Open
Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy
(This special issue belongs to the Section General Surgery)
Thrombotic Risk and Its Management Across Diverse Clinical Settings
edited by Samuel Bogdan Todor and Ana Maria Vlǎdǎreanu
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1197 | Submission Open
Keywords: thrombosis; thrombotic risk; hematologic disorders; thrombophilia; myeloproliferative neoplasms; antithrombotic therapy; cardiovascular diseases; biomarkers
(This special issue belongs to the Section Hematology)
Orthopedic Surgery: Latest Advances and Perspectives
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 997 | Submission Open
Keywords: motion preservation; pain management; robotics/computer navigation; degenerative disc disease; orthobiologics; arthroplasty; trauma
(This special issue belongs to the Section Orthopedics)
Current Advances and Future Perspectives in Interventional Cardiology
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 900 | Submission Open
Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart
(This special issue belongs to the Section Cardiology)
Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery
edited by and Fabrizio Panaro
submission deadline 30 Nov 2025 | 1 articles | Viewed by 862 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances
(This special issue belongs to the Section General Surgery)
Multiparametric Ultrasound Techniques for Liver Disease Assessments
edited by Francesco Giangregorio
submission deadline 30 Nov 2025 | 1 articles | Viewed by 850 | Submission Open
Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Spine Surgery Innovations: Clinically Advanced Treatment and Technologies
edited by Jang W. Yoon
submission deadline 30 Nov 2025 | 1 articles | Viewed by 839 | Submission Open
Keywords: minimally invasive spine surgery; artificial intelligence; wearable biometrics; big data; smartphone accelerometer
(This special issue belongs to the Section Orthopedics)
New Updates in Pediatric Gastroenterology
edited by , Alina Stanescu-Popp and Oana Belei
submission deadline 30 Nov 2025 | Viewed by 751 | Submission Open
Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Transcatheter Aortic Valve Implantation- Clinical Management and Future Challenges
edited by Mohamed Farag
submission deadline 30 Nov 2025 | 1 articles | Viewed by 395 | Submission Open
Keywords: transcatheter aortic valve implantation; TAVI; bicuspid aortic valve; small annulus; prosthesis– patient mismatch; coronary reaccess; valve-in-valve TAVI; leaflet modification
(This special issue belongs to the Section Cardiovascular Medicine)
Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities
edited by , and Francesco Arcuri
submission deadline 30 Nov 2025 | 1 articles | Viewed by 358 | Submission Open
Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Current Challenges in Orthopedic Trauma Surgery
edited by Pietro Maniscalco and Fabrizio Quattrini
submission deadline 30 Nov 2025 | 2 articles | Viewed by 302 | Submission Open
Keywords: hip replacement; knee replacement; shoulder replacement; ankle replacement; trauma surgery; femur; future chal-lenges; surgical innovations
(This special issue belongs to the Section Orthopedics)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 30 Nov 2025 | Viewed by 275 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Anesthesia and Perioperative Management of Organ Transplants
edited by and Ji-Hye Kwon
submission deadline 30 Nov 2025 | Viewed by 261 | Submission Open
Keywords: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension
(This special issue belongs to the Section Anesthesiology)
Challenges in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 30 Nov 2025 | Viewed by 236 | Submission Open
Keywords: glaucoma diagnosis; glaucoma progression; glaucoma biomarkers; intraocular pressure (IOP) management; corneal hysteresis; machine learning in glaucoma detection; neuroprotection in glaucoma; surgery and laser therapy
(This special issue belongs to the Section Ophthalmology)
New Insights into Acne Vulgaris Treatment and Management Strategies
edited by Jo Linda Maria Sinagra
submission deadline 30 Nov 2025 | Viewed by 221 | Submission Open
Keywords: acne; hormonal treatments; isotretinoin; laser therapy; antibiotic
(This special issue belongs to the Section Dermatology)
Clinical Research in Vascular Access Devices
edited by
submission deadline 30 Nov 2025 | Viewed by 208 | Submission Open
Keywords: short peripheral catheters; long peripheral catheters; midline; peripherally inserted central catheters (PICCs); femoral-inserted central catheters (FICCs); centrally inserted central catheters (CICCs); totally implantable venous access devices (TIVAD); catheter-related bloodstream infection (CRBSI); catheter-associated bloodstream infection (CABSI); central line-associated bloodstream infection (CLABSI); catheter-related thrombosis (CRT); fibroblastic sleeve; infiltration; extravasation
(This special issue belongs to the Section Vascular Medicine)
Minimally Invasive Gastrointestinal Surgery: Clinical Advances and Prospects
edited by Jun Suh Lee
submission deadline 30 Nov 2025 | Viewed by 196 | Submission Open
Keywords: minimally invasive surgery; gastrointestinal surgery; laparoscopic surgery; robotic surgery; surgical innovation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest
edited by
submission deadline 30 Nov 2025 | Viewed by 195 | Submission Open
Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies
(This special issue belongs to the Section Cardiovascular Medicine)
Key Quality Indicators in Diagnosis and Treatment of Respiratory Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 188 | Submission Open
Keywords: key quality indicators; respiratory disorders; audit; quality improvement; real-life data
(This special issue belongs to the Section Respiratory Medicine)
Role of Platelet in Inflammation, Infection, and Immune Response submission deadline 30 Nov 2025 | Viewed by 177 | Submission Open
Keywords: platelets; platelet count; dual antiplatelet therapy; inflammation; thrombosis; inflammation; hemostasis; immune response
(This special issue belongs to the Section Hematology)
Technology and Innovations in Microsurgical Reconstruction: Bridging Challenges in Breast, Lymphatic, and Limb Reconstruction
edited by Gordon K. Lee, and
submission deadline 30 Nov 2025 | Viewed by 176 | Submission Open
Keywords: microsurgery; breast reconstruction; limb reconstruction; perforator flaps; super microsurgery; surgical innovation; reconstructive surgery; lymphedema; tissue engineering; diabetic foot reconstruction; wound healing; cell therapy
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Percutaneous Coronary Intervention: Latest Advances and Future Prospects submission deadline 30 Nov 2025 | Viewed by 175 | Submission Open
Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease
(This special issue belongs to the Section Cardiology)
Interventional Cardiology: Clinical Advances and Future Perspectives
edited by Antonio Landi and
submission deadline 30 Nov 2025 | Viewed by 166 | Submission Open
Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome
(This special issue belongs to the Section Cardiology)
Novel Insights into the Clinical Management of Retinal Detachment
edited by Francesco Sabatino
submission deadline 30 Nov 2025 | Viewed by 144 | Submission Open
Keywords: retinal detachment; oil toxicity; gas tamponade; pars plana vitrectomy; scleral buckle; pneumatic retinopexy; surgical techniques; retinal imaging; retinal displacement
(This special issue belongs to the Section Ophthalmology)
Kidney Transplantation: Recent Advances and Challenges
edited by Jose Torrealba
submission deadline 30 Nov 2025 | Viewed by 114 | Submission Open
Keywords: kidney allograft; pathology; HLA and antibodies; management
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances in the Management and Treatment of Obesity
edited by
submission deadline 5 Dec 2025 | 1 articles | Viewed by 4102 | Submission Open
Keywords: obesity; therapy; weight loss; diet; surgery; exercise; personalized medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
AI in Maternal Fetal Medicine and Perinatal Management
edited by Ariel Many
submission deadline 5 Dec 2025 | 2 articles | Viewed by 2522 | Submission Open
Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction
(This special issue belongs to the Section Obstetrics & Gynecology)
Comprehensive Approaches in Plastic and Reconstructive Surgery
edited by Michael Alfertshofer
submission deadline 7 Dec 2025 | 4 articles | Viewed by 5462 | Submission Open
Keywords: plastic surgery; reconstructive surgery; regenerative medicine; advanced surgical planning; trauma reconstruction; patient-specific solutions; multidisciplinary care
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Challenges in Obstetrics and Gynecology: Interactions Between Gynecological and Obstetric Disorders, Quality of Life, and Mental Health in Women
edited by and Daniel María Lubián López
submission deadline 10 Dec 2025 | 7 articles | Viewed by 8829 | Submission Open
Keywords: perinatal mental health; gynecological disorders; sexual disorders; women’ s quality of life; obstetric complications; women’ s health; women’ s psychological well-being
(This special issue belongs to the Section Obstetrics & Gynecology)
State of the Art: Updates in Preterm Labor and Preterm Birth
edited by and Moti Gulersen
submission deadline 10 Dec 2025 | 5 articles | Viewed by 7377 | Submission Open
Keywords: prenatal diagnosis; preterm birth; antenatal corticosteroids; cerclage; multiple gestations
(This special issue belongs to the Section Obstetrics & Gynecology)
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