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Current Challenges in Oral Surgery and Pathology
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Current Challenges in Oral Surgery and Pathology

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 28 September 2026 | Viewed by 1724

Editor

Dr. Christian Bacci

E-Mail Website
Guest Editor
Department of Neurosciences, University of Padova, Padova, Italy
Interests: oral pathology; oral medicine; oral surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of oral surgery and pathology is experiencing a period of rapid transformation, presenting both exciting opportunities and significant challenges. While the fundamental pathologies we encounter remain largely consistent, our approach to classifying and treating these conditions is undergoing radical changes.

Oral surgery is therefore in a constant state of evolution, driven by technological advancements and our deepening understanding of oral diseases. The primary goal of these developments is to enhance treatment efficacy while simultaneously reducing patient morbidity. This dual focus has led to the emergence of innovative surgical techniques and technologies that are reshaping our field.

Consider, for instance, the revolutionary impact of endoscopic technologies, which have dramatically improved visualization during complex procedures. The integration of lasers in oral surgery has brought unprecedented precision to soft tissue management. Operating microscopes have enhanced surgeons' ability to perform intricate manipulations, while piezoelectric devices have revolutionized bone surgery, offering unparalleled control and minimizing damage to the surrounding tissues.

Moreover, the advent of navigated osteotomies has ushered in a new era of accuracy in surgical planning and execution. These technological advancements are complemented by significant progress in anesthesiology and conscious sedation techniques, which have substantially improved our ability to manage patient comfort both during and after surgical procedures.

However, with these advancements come new challenges: Practitioners must continually update their skills and knowledge to effectively utilize these new technologies. Additionally, there are ongoing debates about the cost-effectiveness of some advanced techniques and their accessibility in different healthcare settings.

The purpose of this Special Issue is to collect papers which make significant contributions through addressing these current challenges and to highlight improvements in the field of oral surgery and clinical pathology. We invite contributions that explore new techniques, technologies, and approaches, as well as studies that critically evaluate the efficacy and applicability of these advancements in various clinical contexts.

Dr. Christian Bacci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral medicine
  • oral pathology
  • oral surgery
  • ONJ
  • MRONJ
  • BRONJ
  • laser

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Related Special Issue

Published Papers (2 papers)

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Research

17 pages, 1257 KB  
Article
Frequency and Systemic Associations of Focal Low-Trabeculation/Low-Density Intramedullary Jawbone Findings: A Retrospective CBCT Study
by Marzena Dominiak, Wojciech Niemczyk, Artur Pitułaj, Witold Świenc, Sebastian Dominiak, Konstanty Sławecki, Łucja Janek and Jacek Matys
J. Clin. Med. 2026, 15(17), 6636; https://doi.org/10.3390/jcm15176636 - 27 Aug 2026
Abstract
Background: This exploratory study assessed the frequency of study-defined focal low-trabeculation/low-density intramedullary findings (FLDIFs) in a selected clinical cohort referred for cone-beam computed tomography (CBCT) and examined their associations with demographic, systemic, and radiographic variables. CBCT depicts mineralized trabecular architecture and relative attenuation [...] Read more.
Background: This exploratory study assessed the frequency of study-defined focal low-trabeculation/low-density intramedullary findings (FLDIFs) in a selected clinical cohort referred for cone-beam computed tomography (CBCT) and examined their associations with demographic, systemic, and radiographic variables. CBCT depicts mineralized trabecular architecture and relative attenuation but cannot directly demonstrate marrow fat or establish osteonecrosis; FDOJ/MFI were therefore considered only possible interpretations rather than imaging diagnoses. Methods: A single-center retrospective analysis included 1000 adults whose CBCT examinations met the study image-quality and anatomical-coverage requirements. FLDIF was defined as a descriptive radiological phenotype and was not considered a diagnosis of fatty degenerative osteonecrosis of the jaw (FDOJ), marrow fatty infiltration (MFI), or another specific disorder. Patients were classified as positive when at least one study-defined finding was present; one largest index finding per positive patient was used for finding-level analyses. Results: FLDIFs were identified in 452/1000 patients (45.2%; 95% CI: 42.1–48.3%) within this CBCT-referred cohort. Age was associated with finding presence in the multivariable model (OR 1.015 per year, 95% CI: 1.006–1.025; p = 0.001). Diabetes mellitus also showed an adjusted association (OR 1.647, 95% CI: 1.022–2.686; p = 0.042), which should be regarded as exploratory because of residual confounding and retrospective disease ascertainment. Panoramic radiographs were available for all 452 index findings; 180 (39.8%) were judged visible and 272 (60.2%) not visible. Visible index findings were larger (median 9.2 vs. 8.1 mm; pFDR = 0.003; |rank-biserial r| = 0.19), whereas the relative CBCT gray-scale comparison was not significant after FDR correction. Most index findings (412/452, 91.2%) were located in the mandibular retromolar regions. Conclusions: The 45.2% value represents the frequency of a study-defined, nonspecific radiological phenotype within a selected CBCT-referred cohort and should not be interpreted as population prevalence or as the prevalence of histopathologically confirmed FDOJ/MFI. The findings are hypothesis-generating; they do not establish a screening indication for CBCT based on age or diabetes. The biological and clinical significance of the imaging phenotype remains uncertain and requires external validation in independent cohorts and, when clinically indicated, histopathological or complementary imaging correlation. Full article
(This article belongs to the Special Issue Current Challenges in Oral Surgery and Pathology)
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18 pages, 635 KB  
Article
Radiographic Patterns and Clinical Correlates of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Retrospective Analysis
by Mehmet Altay Sevimay and Sedat Çetiner
J. Clin. Med. 2026, 15(2), 698; https://doi.org/10.3390/jcm15020698 - 15 Jan 2026
Viewed by 1291
Abstract
Objectives: This study aimed to evaluate the radiographic characteristics of medication-related osteonecrosis of the jaw (MRONJ) by digital panoramic radiographs and to investigate the associations between radiographic findings and clinical, demographic, and treatment-related variables in patients receiving antiresorptive therapy. Methods: A retrospective analysis [...] Read more.
Objectives: This study aimed to evaluate the radiographic characteristics of medication-related osteonecrosis of the jaw (MRONJ) by digital panoramic radiographs and to investigate the associations between radiographic findings and clinical, demographic, and treatment-related variables in patients receiving antiresorptive therapy. Methods: A retrospective analysis was performed on 55 patients receiving antiresorptive therapy, categorized into a tooth-extraction group (n = 20) and an MRONJ group (n = 35). Standardized panoramic radiographs obtained at baseline (T0) and during the 6-month follow-up (T1) were evaluated for lamina dura thickness, trabecular bone alteration, osteosclerosis, cancellous bone loss, sequestration, and periosteal response. Statistical analyses were conducted on associations involving drug type, administration route, therapy duration, smoking, diabetes, hypertension, gender, and serum C-terminal telopeptide (CTX) levels. Results: The incidence of sequestrum development and cancellous bone loss was considerably higher in the MRONJ group. Sequestration demonstrated significant associations with both the duration of antiresorptive therapy (>3 years) and intermediate-risk CTX levels. No significant correlations were found between CTX and other radiographic parameters. Lamina dura thickening, trabecular alterations, osteosclerosis, and periosteal reaction exhibited no differences across groups or in relation to smoking, diabetes, age, or gender; periosteal reaction was an uncommon and variable finding. Conclusions: Panoramic radiography provides clinically useful information in the evaluation of MRONJ, particularly for identifying sequestration and cancellous bone degradation. The formation of sequestrum appears to be the most indicative radiographic indicator, representing both the duration of treatment and biochemical risk. Full article
(This article belongs to the Special Issue Current Challenges in Oral Surgery and Pathology)
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