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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Coronary Artery Disease: Diagnosis, Treatment Challenges, and Emerging Therapy submission deadline 20 Sep 2026 | 5 articles | Viewed by 12769 | Submission Open
Keywords: coronary artery disease; percutaneous coronary intervention; cardiovascular disease; emerging therapies; treatment challenges; biomarkers; interventional cardiology
(This special issue belongs to the Section Cardiology)
Current Challenges and New Perspectives in Liver Transplantation
edited by and
submission deadline 20 Sep 2026 | 10 articles | Viewed by 10423 | Submission Open
Keywords: liver transplantation; graft survival; immunosuppression; organ allocation; hepatocellular carcinoma; MASLD; donor shortage; transplant outcomes; innovation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Perspectives on the Diagnosis and Treatment of Cardiomyopathies
edited by Luca Arcari
submission deadline 20 Sep 2026 | 5 articles | Viewed by 9218 | Submission Open
Keywords: cardiomyopathies; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac amyloidosis; arrhythmogenic right ventricular cardiomyopathy; non-dilated left ventricular cardiomyopathy; cardiac magnetic resonance imaging; computed tomography; echocardiography; nuclear imaging
(This special issue belongs to the Section Cardiology)
Thoracic Surgery: State of the Art and Future Directions
edited by and
submission deadline 20 Sep 2026 | 6 articles | Viewed by 8929 | Submission Open
Keywords: thoracic surgery; lung surgery; lung cancer; rib fractures; lung disease; pectus excavatum
(This special issue belongs to the Section Respiratory Medicine)
Cognitive Impairment, Dementia and Depression in Older Adults
edited by Seong Jae Kim and Ilhan Choo
submission deadline 20 Sep 2026 | 3 articles | Viewed by 7230 | Submission Open
Keywords: cognitive impairment; dementia; depression; Parkinson’s disease; artificial intelligence (AI); predictive modeling
(This special issue belongs to the Section Geriatric Medicine)
Advances in Minimally Invasive Gynecologic Surgery: Optimizing Outcomes and Perioperative Strategies
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 5560 | Submission Open
Keywords: minimally invasive gynecologic surgery; MIGS; laparoscopy; robotic surgery; endometrial cancer; endometriosis
(This special issue belongs to the Section Obstetrics & Gynecology)
Maxillomandibular Growth, Reconstruction and Rehabilitation: Orthodontic, Prosthodontic and Surgical Interventions from Childhood to Adulthood
edited by Kamila Chęcińska and
submission deadline 20 Sep 2026 | 5 articles | Viewed by 5534 | Submission Open
Keywords: maxillomandibular growth; orthodontics; prosthodontics; surgical interventions; childhood; adulthood; reconstruction; rehabilitation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Modern Gynecological Surgery: Clinical Updates and Perspectives
edited by , and Maya Sophie de Wilde
submission deadline 20 Sep 2026 | 4 articles | Viewed by 5393 | Submission Open
Keywords: gynecological diseases; gynecological surgery; surgical options; individual treatment; women’s health care
(This special issue belongs to the Section Obstetrics & Gynecology)
New Advances in Systemic Lupus Erythematosus (SLE)
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 5235 | Submission Open
Keywords: systemic lupus erythematosus; autoantibodies and biomarkers; lupus nephritis; new and novel treatments; targeted treatment or precision medicine; quality of life
(This special issue belongs to the Section Immunology & Rheumatology)
New Insights into the Management of Psoriasis and Immune-Mediated Dermatoses
edited by Federico Bardazzi and Riccardo Balestri
submission deadline 20 Sep 2026 | 6 articles | Viewed by 4859 | Submission Open
Keywords: psoriasis; immune-mediated inflammatory diseases; biologic therapy; small-molecule drugs; personalized treatment; real-world evidence; comorbidities; patient-centered care
(This special issue belongs to the Section Dermatology)
Advances in Antithrombotic Therapy in Cardiovascular Medicine
edited by Daniele Giacoppo and Antonio Greco
submission deadline 20 Sep 2026 | 6 articles | Viewed by 4768 | Submission Open
Keywords: anticoagulant; antiplatelet; antithrombotic therapy; cardiovascular pharmacotherapy; coronary artery disease; in-flammation; lipid-lowering drugs; lipid metabolism; residual cardiovascular risk; thrombosis
(This special issue belongs to the Section Cardiovascular Medicine)
Innovations and Advances in Primary Care and Family Medicine
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 4076 | Submission Open
Keywords: primary care; family medicine; integrated care; chronic disease management; multimorbidity; mental health; digital health; artificial intelligence; population health management; implementation research; health services research; interdisciplinary collaboration; evidence-based practice
(This special issue belongs to the Section Epidemiology & Public Health)
Bladder Cancer: Diagnosis and Treatments
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 4045 | Submission Open
Keywords: bladder cancer; urothelial cancer; radical cystectomy; targeted therapy; immunotherapy; non-muscle -invasive; muscle-invasive; chemotherapy
(This special issue belongs to the Section Nephrology & Urology)
Contemporary Oral and Maxillofacial Surgery: Expert Consensus and Best Practices
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 4043 | Submission Open
Keywords: facial trauma; TMJ disorders; implant and sinus surgery; sleep apnea; cosmetic and reconstructive surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Liquid Biopsies in Oral Cancer: Advances and New Perspectives submission deadline 20 Sep 2026 | 1 articles | Viewed by 3837 | Submission Open
Keywords: oral cancer; oral potentially malignant disorders; liquid biopsies; saliva and blood biomarkers; circulating tumor cells (CTCs); cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA); cell-free RNA (cfRNA); extracellular vesicles (EVs); genetic and epigenetic biomarkers; early detection; prognosis and therapy response prediction; precision medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Postpartum Depression: What Happened to My Wife? submission deadline 20 Sep 2026 | 4 articles | Viewed by 3742 | Submission Open
Keywords: postpartum depression; clinical and health psychology; perinatal trauma; clinical and health psychology; mental health and quality of life
(This special issue belongs to the Section Mental Health)
Minimally Invasive and Endoscopic Neurosurgery
edited by , Vassilios Tsitouras and Stylianos Kapetanakis
submission deadline 20 Sep 2026 | 1 articles | Viewed by 3716 | Submission Open
Keywords: traumatic brain injury; neuro-oncology; hydrocephalus and cerebrospinal fluid disorders; neuroendoscopy; endo-scopic neurosurgery; skull base surgery; vascular neurosurgery; functional neurosurgery; pediatric neurosurgey; minimally invasive spine surgery; endoscopic spine surgery; spine endoscopy
(This special issue belongs to the Section Clinical Neurology)
Residual Risk in High-Risk Patients Undergoing Percutaneous Coronary Intervention submission deadline 20 Sep 2026 | 1 articles | Viewed by 3716 | Submission Open
Keywords: cardiology; precision medicine; residual risk; acute coronary syndrome; percutaneous coronary intervention; PCI
(This special issue belongs to the Section Cardiology)
Innovations in Emergency and Critical Care Medicine
edited by Yoshiaki Iwashita
submission deadline 20 Sep 2026 | 3 articles | Viewed by 3586 | Submission Open
Keywords: emergency; artificial intelligence; Tele-ICU; point of care; electrical impedance tomography
(This special issue belongs to the Section Intensive Care)
Advancements and Challenges in Retina Surgery: Second Edition
edited by Joaquín Marticorena and
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3487 | Submission Open
Keywords: retina; vitreoretinal diseases; vitreotomes; optical coherence tomography; vitreoretinal surgery
(This special issue belongs to the Section Ophthalmology)
Clinical Management in Chronic Pain: Innovations, Integration, and Interventions
edited by Giuliano Lo Bianco, Silvia Natoli and Sean Li
submission deadline 20 Sep 2026 | 3 articles | Viewed by 3397 | Submission Open
Keywords: chronic pain; clinical management; interventional pain medicine; spinal cord stimulation; regenerative medicine; diagnostic strategies; pain semeiotics; multidisciplinary approaches; personalized medicine; pain assessment; neuromodulation; evidence-based pain therapy
(This special issue belongs to the Section Clinical Neurology)
Personalized Treatments for Patients with Acute Lung Injury
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 3392 | Submission Open
Keywords: personalized; acute lung injury; acute respiratory distress syndrome (ARDS); ventilator-induced lung injury (VILI); pharmacotherapy; fluid resuscitation; phenotypes; mesenchymal stem cells; nano-systems; exosomes; biomarkers; computational models
(This special issue belongs to the Section Respiratory Medicine)
Clinical Research and Insights in Endometriosis submission deadline 20 Sep 2026 | 3 articles | Viewed by 3052 | Submission Open
Keywords: endometriosis; pelvic pain; infertility; inflammation; minimal access surgery; laparoscopy; hysteroscopy; robotics
(This special issue belongs to the Section Obstetrics & Gynecology)
Polycystic Ovary Syndrome (PCOS): From Diagnosis to Personalized and Integrated Treatment
edited by Satu Kuokkanen
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2963 | Submission Open
Keywords: PCOS; integrated treatment model; metabolic abnormalities; mental health; adverse obstetric outcomes
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Emerging Treatment Options in Atrial Fibrillation
edited by Hoang Nhat Pham and Amitoj Singh
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2954 | Submission Open
Keywords: atrial fibrillation; AF ablation; lifestyle intervention; rhythm control; pulsed field ablation; antiarrhythmic drugs; direct oral anticoagulants
(This special issue belongs to the Section Cardiology)
Acute Ischemic Heart Disease: Risk Factors, Diagnosis, Management and Prognosis
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 2879 | Submission Open
Keywords: acute coronary syndromes; STEMI; cardiogenic shock; primary angioplasty; antiplatelet therapies; anticoagulation; stent thrombosis; mechanical support devices; acute heart failure
(This special issue belongs to the Section Cardiology)
Minimally Invasive Surgery: Challenges and Solutions in Clinical Practice
edited by and Alessia Fassari
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2860 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; surgical challenges; clinical practice; surgical training; robotic-assisted surgery; artificial intelligence in surgery; laparoscopic instrumentation; intraoperative complications; surgical innovation; skill enhancement; surgical outcomes
(This special issue belongs to the Section General Surgery)
Advances and Challenges in Colorectal Cancer
edited by Vignesh Narasimhan
submission deadline 20 Sep 2026 | 4 articles | Viewed by 2833 | Submission Open
Keywords: anal fistula; advancement flap; ‎ligation of intersphincteric tract; haemorrhoid surgery; pilonidal surgery
(This special issue belongs to the Section Oncology)
Bridging Bench, Bedside, and Beyond: Clinical and Translational Strategies for Pregnancy Complications submission deadline 20 Sep 2026 | 3 articles | Viewed by 2830 | Submission Open
Keywords: high-risk pregnancy; cardiovascular complications; cardiometabolic complications; gestational diabetes; pregnancy complications; preeclampsia; hypertension; vascular disorders; endothelial dysfunction; clinical prediction; antenatal diagnosis; personalized treatment
(This special issue belongs to the Section Obstetrics & Gynecology)
Pediatric Otolaryngology: Clinical Advances and Challenges submission deadline 20 Sep 2026 | 3 articles | Viewed by 2671 | Submission Open
Keywords: pediatric dizziness; laryngomalacia; subglottic stenosis; pediatric airway obstruction; intracapsular tonsillectomy; PITA (Powered Intracapsular Tonsillectomy and Adenoidectomy); pediatric sleep-disordered breathing; pediatric olfactory disorders; congenital anosmia
(This special issue belongs to the Section Clinical Pediatrics)
Up-to-Date Research on Nerve Ultrasound
edited by and Eman A. Tawfik
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2602 | Submission Open
Keywords: peripheral nerve ultrasound; polyneuropathy; nerve trauma; plexus neuritis; nerve tumors; entrapment syndromes; ultrasound techniques; guidelines
(This special issue belongs to the Section Clinical Neurology)
Emerging Radiotherapy Technologies and Trends
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2590 | Submission Open
Keywords: image-guided radiotherapy (IGRT); 4D radiotherapy; SBRT; radiomics; FLASH therapy; MR-guided radiotherapy
(This special issue belongs to the Section Oncology)
Alopecia, Atopic Dermatitis and Other Chronic Inflammatory Skin Diseases: Pathogenesis, Comorbidities, and Precision Management submission deadline 20 Sep 2026 | 4 articles | Viewed by 2549 | Submission Open
Keywords: alopecia; atopic dermatitis; chronic urticaria; prurigo nodularis; chronic pruritus; inflammatory skin diseases; biomarkers; biologics; JAK inhibitors; quality of life; precision medicine
(This special issue belongs to the Section Dermatology)
Clinical Research and Application of Artificial Intelligence and Deep Learning in Dentistry and Oral and Maxillofacial Surgery
edited by , and Lara Katharina Franziska Schorn
submission deadline 20 Sep 2026 | 4 articles | Viewed by 2454 | Submission Open
Keywords: artificial intelligence; deep learning; machine learning; oral and maxillofacial surgery; dentistry; medical imaging; clinical decision support
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Neurological Injury After Cardiac Arrest: Mechanisms, Prognostication, and Emerging Therapies
edited by and Nikos Gorgoraptis
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2397 | Submission Open
Keywords: cardiac arrest; hypoxic–ischaemic brain injury; neuroprognostication; neuroprotection; biomarkers; targeted tem-perature management; multimodal monitoring; neurorehabilitation
(This special issue belongs to the Section Emergency Medicine)
Management of Dyslipidemias: Enhancing Lipid Modification to Reduce Cardiovascular Risk: 2nd Edition
edited by and Etienne Khoury
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2377 | Submission Open
Keywords: cardiovascular disease; dyslipidemia; lipoprotein remnant; emerging lipid-lowering therapies; rare and severe causes of atherogenic lipid disorders; cardiovascular risk-related biomarkers; drug safety and efficacy
(This special issue belongs to the Section Cardiovascular Medicine)
Current Challenges and Approaches to Post-Traumatic Stress Disorder (PTSD)
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2150 | Submission Open
Keywords: PTSD treatment; implementation; prevention; prevalence; risk factors
(This special issue belongs to the Section Mental Health)
Current Clinical Research in Oral Maxillofacial Surgery
edited by , Marcin Kozakiewicz, Łukasz J. Krakowczyk and Tadeusz Morawiec
submission deadline 20 Sep 2026 | 4 articles | Viewed by 2036 | Submission Open
Keywords: oral and maxillofacial surgery; craniofacial surgery; orthognathic surgery; maxillofacial trauma; head and neck oncology; microsurgical reconstruction; temporomandibular joint (TMJ); virtual surgical planning (VSP); patient-specific implants (PSI); complications and outcomes
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Digestive Disorders: Updates on Disease Monitoring, Prediction Models and Management submission deadline 20 Sep 2026 | 3 articles | Viewed by 2019 | Submission Open
Keywords: inflammatory bowel disease; metabolic dysfunction-associated fatty liver disease; liver disease; alcohol related liver disease; infection; Clostridioides difficile infection
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Diagnosis and Treatment of Uveitis
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1937 | Submission Open
Keywords: uveitis; intraocular tumors; medical retina; pediatric retina
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Autism Management submission deadline 20 Sep 2026 | 1 articles | Viewed by 1834 | Submission Open
Keywords: autism spectrum disorder; diagnosis; child; adult; youth; early intervention; therapy; epidemiology; relatives; resources; limitations; problems; health; epidemiology; perspectives; organization
(This special issue belongs to the Section Mental Health)
Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies
edited by Alessandro Andreis, and
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1826 | Submission Open
Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology
(This special issue belongs to the Section Cardiology)
Pediatric Oral Health: Developmental, Functional, and Special Care Perspectives submission deadline 20 Sep 2026 | 2 articles | Viewed by 1796 | Submission Open
Keywords: pediatric oral health; early childhood oral health; malocclusion; oral habits; craniofacial growth and development; dental development defects; dental trauma in children; orofacial functions; oral–systemic health; preventive and community dentistry; early oral intervention
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Rehabilitation in Musculoskeletal Disease
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1777 | Submission Open
Keywords: musculoskeletal disease; stroke rehabilitation; physical therapy; rehabilitation; chronic pain; manual therapy; exercise intervention
(This special issue belongs to the Section Clinical Rehabilitation)
Atrial Fibrillation: Screening, Management and Outcomes
edited by Ahmed AlTurki and Vidal Essebag
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1767 | Submission Open
Keywords: atrial fibrillation; ablation; pulmonary vein isolation; atrial fibrillation screening; wearable devices; anti-arrhythmic drugs; cardiovascular outcomes; subclinical atrial fibrillation
(This special issue belongs to the Section Cardiology)
Advances in Managing High-Risk Pregnancies: Innovations in Diagnosis, Prevention and Clinical Care
edited by , Vivien Dütemeyer and Jacques Jani
submission deadline 20 Sep 2026 | 3 articles | Viewed by 1636 | Submission Open
Keywords: high-risk pregnancy; maternal–fetal medicine; prenatal diagnosis; fetal growth restriction; preeclampsia; preterm birth; biomarkers; maternal comorbidities; clinical imaging; precision obstetrics
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Physical Therapy for Healthy Aging: Innovative and Functional Rehabilitation Approaches submission deadline 20 Sep 2026 | 3 articles | Viewed by 1580 | Submission Open
Keywords: physical therapy; healthy aging; functional rehabilitation; therapeutic exercise; motor control; pelvic floor rehabilitation; preventive interventions
(This special issue belongs to the Section Clinical Rehabilitation)
Current Advances in Artificial Intelligence in Oral Cancer Research, Early Diagnosis, and Personalized Therapy
edited by Aminollah Khormali
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1545 | Submission Open
Keywords: artificial intelligence; precision oncology; digital pathology; deep learning; early cancer detection; predic-tive modeling; oral cancer diagnostics
(This special issue belongs to the Section Oncology)
Recent Progress and Future Perspectives in Orthodontics submission deadline 20 Sep 2026 | 2 articles | Viewed by 1511 | Submission Open
Keywords: skeletal anchorage; temporary anchorage devices; multidisciplinary orthodontic treatment; digital orthodontics; clear aligner therapy; 3D imaging and virtual treatment planning; airway-focused orthodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Challenges and Future Directions of Interstitial Lung Disease
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1402 | Submission Open
Keywords: interstitial lung disease; progressive pulmonary fibrosis; early detection; clinical diagnosis; multidisciplinary discussion; treatment; non-pharmacological therapy; end-of-life care; patient-centered management
(This special issue belongs to the Section Respiratory Medicine)
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