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Current Clinical Research in Oral Maxillofacial Surgery
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Current Clinical Research in Oral Maxillofacial Surgery

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 2178

Editors

Prof. Dr. Krzysztof Dowgierd

E-Mail Website
Guest Editor
Head and Neck Surgery, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland
Interests: maxillofacial surgery; head and neck surgery; reconstructive surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marcin Kozakiewicz

E-Mail Website
Guest Editor
Department of Maxillofacial Surgery, Medical University of Lodz, Lodz, Poland
Interests: oral and maxillofacial surgery; maxillofacial surgery; traumatology; deformation treatment; head and neck oncology; infections treatment; human orbital reconstructions; mandibular condyle fixing material; custom-made temporomandibular joint replacements; bone substitute materials; implantology; surgery-first facial deformation algorithm
Prof. Dr. Łukasz J. Krakowczyk

E-Mail Website
Guest Editor
1st Department of Oncological Surgery with Subunit of Reconstructive and Plastic Surgery, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
Interests: cancer surgery; reconstructive surgery; head and neck surgery; oral and maxillofacial surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Tadeusz Morawiec

E-Mail Website
Guest Editor
Department of Dental Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Bytom, Poland
Interests: oral; oral surgery; dental implants; dentistry

Special Issue Information

Dear Colleagues,

This Special Issue, Current Clinical Research in Oral Maxillofacial Surgery, aims to present high-quality clinical and translational evidence addressing contemporary challenges in OMFS. We welcome original research, prospective and retrospective clinical studies, systematic reviews covering the full spectrum of maxillofacial and craniofacial surgery, including trauma, orthognathic surgery, congenital deformities, head and neck oncology, reconstructive and microsurgical procedures, and temporomandibular joint (TMJ) disorders. Particular emphasis is placed on modern diagnostic pathways, perioperative decision-making, complication analysis and prevention, functional and aesthetic outcomes, and patient-reported measures. We also encourage submissions on digital workflows (CBCT/CT, MRI, 3D planning, navigation), patient-specific implants and devices, and biomechanics that improve safety and predictability. Our goal is to provide an up-to-date, clinically practical collection of papers that supports evidence-based treatment and stimulates further collaboration across OMFS centres.

Prof. Dr. Krzysztof Dowgierd
Prof. Dr. Marcin Kozakiewicz
Prof. Dr. Łukasz J. Krakowczyk
Prof. Dr. Tadeusz Morawiec
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral and maxillofacial surgery
  • craniofacial surgery
  • orthognathic surgery
  • maxillofacial trauma
  • head and neck oncology
  • microsurgical reconstruction
  • temporomandibular joint (TMJ)
  • virtual surgical planning (VSP)
  • patient-specific implants (PSI)
  • complications and outcomes

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Published Papers (4 papers)

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Research

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19 pages, 7789 KB  
Article
Epidemiological Assessment of Oral and Oropharyngeal Squamous Cell Carcinomas Before, During, and After the COVID-19 Pandemic, 2018–2024
by George Cătălin Alexandru, Călin Muntean, Doina Chioran, Mircea Riviș, Loredana-Neli Gligor, Marius Octavian Pricop and Tudor Rareş Olariu
J. Clin. Med. 2026, 15(18), 6963; https://doi.org/10.3390/jcm15186963 - 8 Sep 2026
Viewed by 178
Abstract
Background/Objectives: Evidence regarding changes in oral and oropharyngeal squamous cell carcinoma (SCC) care across the COVID-19 pandemic remains limited, particularly in Eastern Europe. This study evaluated temporal changes in surgical admission volume, operative complexity, and comorbidity burden before, during, and after the pandemic [...] Read more.
Background/Objectives: Evidence regarding changes in oral and oropharyngeal squamous cell carcinoma (SCC) care across the COVID-19 pandemic remains limited, particularly in Eastern Europe. This study evaluated temporal changes in surgical admission volume, operative complexity, and comorbidity burden before, during, and after the pandemic at a Romanian tertiary maxillofacial center. Methods: This retrospective mixed-methods study included 248 admissions for oral and oropharyngeal SCC between 2018 and 2024. A structured administrative database was deterministically linked to narrative discharge summaries. Admissions were grouped into pre-pandemic (n = 117), pandemic (n = 93), and post-pandemic (n = 38) periods. Statistical analyses included between-period comparisons, segmented interrupted time-series analysis, and multivariable logistic regression. Qualitative thematic analysis was used to contextualize surgical and perioperative complexity. Results: Mean monthly admissions decreased from 4.9 before the pandemic to 2.6 during the pandemic and 1.6 in the post-pandemic period. Interrupted time-series analysis identified a significant declining baseline monthly trend (IRR 0.973, 95% CI 0.950–0.996; p = 0.024), without a significant immediate level change or post-onset slope change. Neck dissection increased from 23.9% before the pandemic to 39.8% during the pandemic (p = 0.045) and was independently associated with the pandemic/post-pandemic period (adjusted OR 1.87, 95% CI 1.06–3.29; p = 0.030). Qualitative findings identified recurrent codes related to surgical complexity, reconstruction, extensive nodal surgery, comorbidity burden, and perioperative management. Conclusions: Oral and oropharyngeal SCC surgical admissions showed a significant declining baseline trend between 2018 and 2024, while patients treated during and after the pandemic had higher adjusted odds of undergoing neck dissection. The findings support sustained oncological surveillance, timely referral, and multidisciplinary perioperative planning. Further multicenter studies incorporating standardized tumor–node–metastasis (TNM) staging and human papillomavirus (HPV) documentation are required to confirm these observations. Full article
(This article belongs to the Special Issue Current Clinical Research in Oral Maxillofacial Surgery)
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13 pages, 876 KB  
Article
Stage-Adapted Cryotherapy-Based Management of Oral Mucosal Melanoma: A Single-Center Retrospective Cohort
by Yumin Wu, Xinyu Zhu, Zongxi Wu, Yahui Wang, Wanting Jia, Guiqing Liao and Yujie Liang
J. Clin. Med. 2026, 15(15), 5893; https://doi.org/10.3390/jcm15155893 - 28 Jul 2026
Viewed by 386
Abstract
Background/Objectives: Oral mucosal melanoma (OMM) is a malignancy in which durable local control must be balanced against preservation of speech, swallowing, mastication, and oral structure. Although cryotherapy is a repeatable and function-preserving local modality, its role within contemporary multidisciplinary care has not [...] Read more.
Background/Objectives: Oral mucosal melanoma (OMM) is a malignancy in which durable local control must be balanced against preservation of speech, swallowing, mastication, and oral structure. Although cryotherapy is a repeatable and function-preserving local modality, its role within contemporary multidisciplinary care has not been clearly defined. This study describes a stage-adapted cryotherapy-based management framework for primary OMM and evaluates survival, local recurrence, and prognostic factors in a contemporary single-center cohort. Methods: We retrospectively reviewed 43 patients with primary OMM treated between 2016 and 2026. Treatment allocation was non-randomized and made through multidisciplinary assessment: stage II–III patients received cryotherapy alone, whereas stage IV patients received cryotherapy combined with wide local excision; postoperative adjuvant therapy was considered individually. Overall survival (OS) was estimated using Kaplan–Meier methods, and prognostic factors were explored using univariable Cox regression. Results: Median follow-up was 35 months. Estimated 2-year and 5-year OS for the whole cohort were 93.0% and 69.8%, respectively. Local recurrence occurred in 2/11 stage II–III patients and 18/32 stage IV patients. Among stage IV patients, postoperative adjuvant therapy was associated with OS in an unadjusted exploratory comparison (p = 0.03); this association may be affected by confounding by indication and selection bias and should not be interpreted as a treatment effect. Nodal metastasis was associated with worse OS in univariable analysis (HR, 3.342; p = 0.036). Conclusions: This small, single-center, non-randomized cohort describes an institutional stage-adapted cryotherapy-based management framework for OMM. The findings do not establish comparative efficacy or objectively demonstrate functional preservation. Prospective multicenter studies with standardized treatment selection, complete treatment reporting, validated functional outcomes, and quality-of-life measures are required. Full article
(This article belongs to the Special Issue Current Clinical Research in Oral Maxillofacial Surgery)
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20 pages, 1860 KB  
Article
Systemic Inflammation, Tumor Isotopic Signatures, and Prognosis in Oral Squamous Cell Carcinoma: Exploratory Integration of Blood- and Tissue-Derived Biomarkers—An Exploratory Retrospective Secondary Analysis
by Katarzyna Bogusiak, Piotr Paneth, Marcin Majchrzak, Marcin Kozakiewicz and Józef Kobos
J. Clin. Med. 2026, 15(13), 5278; https://doi.org/10.3390/jcm15135278 - 6 Jul 2026
Viewed by 435
Abstract
Background/Objectives: Oral squamous cell carcinoma (OSCC) remains clinically heterogeneous, and prognosis is not always fully explained by conventional clinicopathological parameters. Systemic inflammation and tumor metabolic alterations may provide complementary information on tumor biology. This study aimed to assess associations between preoperative inflammatory [...] Read more.
Background/Objectives: Oral squamous cell carcinoma (OSCC) remains clinically heterogeneous, and prognosis is not always fully explained by conventional clinicopathological parameters. Systemic inflammation and tumor metabolic alterations may provide complementary information on tumor biology. This study aimed to assess associations between preoperative inflammatory markers, isotope ratio mass spectrometry (IRMS)-derived tumor signatures, clinicopathological features, and survival outcomes in OSCC. Methods: This exploratory retrospective secondary analysis included 50 consecutive patients with surgically treated, histologically confirmed OSCC. Preoperative blood-based markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), white blood cell count, lymphocyte count, and C-reactive protein, were retrieved from routine laboratory tests. Matched tumor, surgical margin, and healthy oral mucosa samples were analyzed by IRMS for δ13C, δ15N, carbon and nitrogen content, and [N]/[C] ratio. Associations with clinicopathological variables, nodal status, overall survival (OS), and disease-free survival (DFS) were evaluated using non-parametric tests, Spearman correlations, and Cox regression models. Results: Tumor tissue showed a consistent isotope and elemental phenotype compared with healthy mucosa, including higher nitrogen content, lower carbon content, increased [N]/[C] ratio, lower δ15N, and less negative δ13C values. NLR, PLR, SII, and CRP were not robustly associated with standard clinicopathological features after correction for multiple testing. Correlations between inflammatory and isotope-derived parameters were modest. Higher NLR was associated with worse OS and DFS and remained significant after adjustment for pathologic nodal status. Less negative tumor δ13C showed a potential adverse prognostic signal. Conclusions: Systemic inflammatory markers and IRMS-derived tumor signatures appear to reflect partly distinct biological domains in OSCC. NLR may provide accessible prognostic information, while tumor δ13C warrants further validation as a metabolic biomarker. Full article
(This article belongs to the Special Issue Current Clinical Research in Oral Maxillofacial Surgery)
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Review

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16 pages, 1042 KB  
Review
Injectable Therapies for Orofacial Myofascial Pain: A Rapid Review of Randomized Controlled Trials
by Karolina Grzybowska-Kowalczyk, Izabella Chyży, Kamila Chęcińska, Wojciech Macek, Maja Kosińska, Maciej Chęciński, Amelia Hoppe, Julia Kasprzycka, Oliwia Jagiełło, Tomasz Horodniczy, Zuzanna Baniak and Maciej Sikora
J. Clin. Med. 2026, 15(13), 5143; https://doi.org/10.3390/jcm15135143 - 1 Jul 2026
Viewed by 538
Abstract
Background/Objectives: Orofacial myofascial pain (MFP) is one of the leading causes of chronic orofacial pain, often resulting in functional limitations and a compromised quality of life. Intramuscular injection therapies appear to be a promising alternative for patients resistant to conservative treatment. The objective [...] Read more.
Background/Objectives: Orofacial myofascial pain (MFP) is one of the leading causes of chronic orofacial pain, often resulting in functional limitations and a compromised quality of life. Intramuscular injection therapies appear to be a promising alternative for patients resistant to conservative treatment. The objective of this rapid review was to synthesize evidence from randomized controlled trials evaluating intramuscular injectable therapies for orofacial myofascial pain. Specifically, the review aimed to compare the clinical effects of different injectable agents on pain intensity, mandibular function, and patient-reported outcomes, and to identify methodological limitations and research gaps within the current evidence base. Methods: A comprehensive search across five databases (ACM, BASE, Cochrane, PubMed, and Scopus) was conducted on March 15, 2026. Randomized controlled trials (RCTs) published between 2022 and 2026 that investigated the use of active injectable agents into the masticatory muscles for clinically diagnosed myofascial pain syndrome were included. Data regarding post-interventional pain intensity, masticatory function, mandibular range of motion, and safety were extracted to compare therapeutic efficacy across interventions. Results: A total of five RCTs met the inclusion criteria. Eligible studies evaluated intramuscular injections of botulinum toxin A, platelet-rich plasma (PRP), magnesium sulfate, and lidocaine, with sample sizes ranging from 30 to 180 participants. Across all interventions, consistent reductions in pain intensity and enhancements in masticatory function were observed. Furthermore, no major adverse events were reported. Conclusions: Intramuscular injectable therapies represent an emerging approach for reducing orofacial myofascial pain, particularly as a treatment for patients with persistent symptoms. Full article
(This article belongs to the Special Issue Current Clinical Research in Oral Maxillofacial Surgery)
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