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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Implant Dentistry: New Challenges and Complication Management
edited by Jordi Gargallo
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2276 | Submission Open
Keywords: navigation surgery; accuracy; computer-aided surgery; computer-assisted; three-dimensional imaging; fixed implant prostheses; zirconia; CAD/CAM; patient satisfaction; peri-implantitis; quality of life; retreatment; tooth loss; connective tissue; keratinized tissue; soft tissue management; bone regeneration; bone grafting; immediate implant placement; immediate implant loading
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Preoperative Optimization in Cardiac Surgery
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2218 | Submission Open
Keywords: preoperative optimization; cardiac surgery; risk assessment; comorbid conditions; multidisciplinary collaboration; perioperative risks; cardiovascular evaluation
(This special issue belongs to the Section Cardiology)
Respiratory Medicine in the Oldest-Old
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2134 | Submission Open
Keywords: oldest-old; respiratory system with aging; pneumonia; epidemiology; COPD; interstitial lung disease; bronchial asthma; lung cancer; mycobacterial or fungal infections; peri-/post-operative status; respiratory frailty; social problems and end of life
(This special issue belongs to the Section Respiratory Medicine)
Novel Insights into Clinical Diagnosis and Management of Degenerative Cervical Myelopathy
edited by , Francesco Costa and Filippo Maria Polli
submission deadline 20 Apr 2026 | 2 articles | Viewed by 1983 | Submission Open
Keywords: degenerative cervical myelopathy (DCM); cervical spondylotic myelopathy (CSM); cervical spinal stenosis; cervical cord compression; MRI of the cervical spine; cervical spine surgery; physical therapy; rehabilitation; ossification of the posterior longitudinal ligament (OPLL); cervical deformity (e.g.; kyphosis and lordosis); patient-reported out-comes; surgical outcome prediction
(This special issue belongs to the Section Clinical Neurology)
Current Challenges and Innovations in Spine Deformity: Biomechanics, Imaging and AI-Driven Analysis
edited by Dong-Ho Kang
submission deadline 20 Apr 2026 | 2 articles | Viewed by 1670 | Submission Open
Keywords: spinal deformity; cervical deformity; biomechanics; postural alignment; sagittal imbalance; medical imaging; radiographic analysis; artificial intelligence; machine learning; deep learning; phenotyping; computer-assisted diagnosis; predictive modeling; surgical planning
(This special issue belongs to the Section Orthopedics)
Clinical Insights in Maternal–Fetal Medicine
edited by Moti Gulersen
submission deadline 20 Apr 2026 | 2 articles | Viewed by 1541 | Submission Open
Keywords: preterm birth; antenatal corticosteroids; preeclampsia; ultrasound; fetal growth; congenital anomalies; infection; maternal morbidity; diabetes; multiple gestation
(This special issue belongs to the Section Obstetrics & Gynecology)
Total Joint Arthroplasty: Clinical Advances and Innovations in Surgical Techniques and Rehabilitation
edited by , Marco Minelli and Federico Della Rocca
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1526 | Submission Open
Keywords: total joint arthroplasty; hip replacement; knee arthroplasty; robotic-assisted surgery; minimally invasive techniques; implant design; postoperative rehabilitation; periprosthetic joint infection; surgical innovation
(This special issue belongs to the Section Orthopedics)
Novel Technologies to Assist Emergency Medical Care
edited by and Young Soon Cho
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1518 | Submission Open
Keywords: emergency medical services; artificial intelligence in emergency medicine; telemedicine and remote patient monitoring; wearable health technologies; point-of-care diagnostics; automated decision support systems; robotics in emergency medicine; pre-hospital care innovations
(This special issue belongs to the Section Emergency Medicine)
New Insights into Acne Vulgaris Treatment and Management Strategies
edited by Jo Linda Maria Sinagra
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1511 | Submission Open
Keywords: acne; hormonal treatments; isotretinoin; laser therapy; antibiotic
(This special issue belongs to the Section Dermatology)
Clinical Update on Thoracic Trauma
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 1394 | Submission Open
Keywords: flail chest; isolated sternal fractures; manubrio-sternal dislocation; pneumothorax; hemothorax; thoracic aortic injury; heart and pulmonary vessels lesion; intercostal artery injury; diaphragm rupture; thoracoabdominal hernia; chylothorax; esophageal perforation
(This special issue belongs to the Section Respiratory Medicine)
Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition
edited by Michael D. Diamantidis
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1233 | Submission Open
Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)
(This special issue belongs to the Section Hematology)
Orofacial Pain: Innovations in Treatment Modalities and Patient Care
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1195 | Submission Open
Keywords: orofacial pain; treatment; patient care; oral dysfunction; chronic pain; burning mouth syndrome; temporomandibular joint pain: oral cenesthopathy; atypical odontalgia; phantom bite syndrome
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Pediatric Dentistry: Real-World Clinical Insights submission deadline 20 Apr 2026 | 1 articles | Viewed by 1161 | Submission Open
Keywords: pediatric dentistry; minimally invasive dentistry; new technologies; biomaterials; innovative management approaches; caries management; pulp management; dental trauma; molar incisor hypomineralization; public health services research; epidemiological research; translational research
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Maternal Fetal Medicine
edited by and Anna Franca Cavaliere
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1080 | Submission Open
Keywords: drugs use during pregnancy; fetal treatment; pregnancy complications; infectious diseases; neonatal poor adaptation syndrome
(This special issue belongs to the Section Obstetrics & Gynecology)
Recent Advances in Endocrine Surgery—2nd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1035 | Submission Open
Keywords: endocrine surgery; thyroid; thyroid cancer; parathyroid; parathyroidectomy; adrenal glands; disorders of hepatobiliary and gastrointestinal tract
(This special issue belongs to the Section General Surgery)
Ischemic and Hemorrhagic Complications of Uncommon Cerebrovascular Diseases: Cutting-Edge Clinical Research, Reviews, and Expert Opinions
edited by Mariel G. Kozberg and Alexis T. Roy
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1023 | Submission Open
Keywords: cerebrovascular disease; ischemic stroke; hemorrhagic stroke; genetics; vasculopathy; headache; superficial siderosis; vascular malformations
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates in Imaging of Musculoskeletal Diseases submission deadline 20 Apr 2026 | 2 articles | Viewed by 1003 | Submission Open
Keywords: musculoskeletal imaging; ultrasound; magnetic resonance; sport imaging; rheumatology; nerve imaging
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Optimizing Outcomes in Emergency Medicine and Cardiopulmonary Resuscitation submission deadline 20 Apr 2026 | 1 articles | Viewed by 960 | Submission Open
Keywords: emergency medicine; cardiopulmonary resuscitation; prehospital care; outcome prediction; post-pesuscitation care; advanced life support; emergency response systems; medical ethics; simulation in medicine
(This special issue belongs to the Section Emergency Medicine)
Carotid Artery Disease (CAD) and Its Complications: A Comprehensive Update
edited by Yacob G. Tedla
submission deadline 20 Apr 2026 | 1 articles | Viewed by 909 | Submission Open
Keywords: carotid artery disease; ischemic stroke; vascular dementia; transient ischemic attack; vascular imaging; carotid endarterectomy; carotid stent placement; risk stratification
(This special issue belongs to the Section Vascular Medicine)
Clinical Updates in Pediatric Radiology submission deadline 20 Apr 2026 | Viewed by 809 | Submission Open
Keywords: pediatric radiology; advances in pediatric imaging; pediatric neuroimaging; artificial in-telligence in pediatric imaging; radiomics and machine learning; low-field MRI techniques; magnetic resonance imaging in pediatrics; computed tomography in pediatrics; radiation dose optimization; patient-centred imaging protocols
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Advances in Minimally Invasive Spinal Treatment: 2nd Edition submission deadline 20 Apr 2026 | 1 articles | Viewed by 718 | Submission Open
Keywords: robotic-assisted spine surgery; artificial intelligence (AI); machine learning (ML); cement-augmented pedicle screws; cement leakage risk stratification; osteoporosis pharmacotherapy; surgical navigation systems; image-guided spine surgery; predictive analytics in spine care; spine technology innovation
(This special issue belongs to the Section Orthopedics)
Intrarenal Surgery for Kidney Stones and Other Kidney Diseases
edited by Razvan Multescu
submission deadline 20 Apr 2026 | 1 articles | Viewed by 713 | Submission Open
Keywords: intrarenal surgery; flexible ureteroscopy; percutaneous nephrolithotomy (PCNL); Mini-PCNL; thulium laser; ureteral access sheaths; flexible and navigable suction (FANS); upper urinary tract urothelial tumors
(This special issue belongs to the Section Nephrology & Urology)
Cardiac MRI: Current Techniques and Future Directions
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 701 | Submission Open
Keywords: cardiac magnetic resonance imaging; technology; sequences; applications; acute coronary syndrome; intravascular imaging; CT-scanner
(This special issue belongs to the Section Cardiology)
New Advances and Clinical Outcomes of Endocrinology
edited by Stefana Catalina Bilha and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 670 | Submission Open
Keywords: endocrinology; obesity; metabolic and bone disease; chronic conditions
(This special issue belongs to the Section Endocrinology & Metabolism)
Peritoneal Dialysis and Hemodialysis: Early and Late Outcomes submission deadline 20 Apr 2026 | 1 articles | Viewed by 512 | Submission Open
Keywords: peritoneal dialysis; dialysis; hemodialysis; chronic kidney disease; end-stage renal disease
(This special issue belongs to the Section Nephrology & Urology)
Innate Immunity in Overdrive: Novel Insights into Autoinflammatory Syndromes
edited by Alessandro Conforti
submission deadline 20 Apr 2026 | 1 articles | Viewed by 502 | Submission Open
Keywords: autoinflammatory diseases; innate immunity; inflammasome; cytokines; Interleukin-1; monogenic syndromes; polygenic autoinflammatory disorders; adult-onset Still’ s disease; Behç et’ s disease; targeted therapy; disease registries; real-world evidence; VEXAS syndrome; UBA1 mutations; precision medicine; biomarkers; outcome assessment
(This special issue belongs to the Section Immunology & Rheumatology)
Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes
edited by Athanassios A. Kyrgidis and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 440 | Submission Open
Keywords: skin cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; clinical biomarkers; dermoscopy; quality of life
(This special issue belongs to the Section Dermatology)
New Advances in Orthopedic Knee Joint Preserving and Reconstructive Surgery
edited by and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 421 | Submission Open
Keywords: cartilage regeneration; patient-specific instrumentation; knee robotic surgery; patient-specific surgical device; future orthopedics
(This special issue belongs to the Section Orthopedics)
Advancements in Minimally Invasive Neurosurgery
edited by Sanjeeva Jeyaretna and Kumar Abhinav
submission deadline 20 Apr 2026 | 1 articles | Viewed by 383 | Submission Open
Keywords: minimally invasive surgery; skull base surgery; neurosurgery; transorbital; endoscopic transnasal
(This special issue belongs to the Section Clinical Neurology)
Hip and Knee Arthroplasty: Update on Clinical Management
edited by Maximilian F. Kasparek
submission deadline 20 Apr 2026 | 1 articles | Viewed by 348 | Submission Open
Keywords: total hip arthroplasty (THA); total knee arthroplasty (TKA); revision arthroplasty; implant fixation; cemented; cementless; hybrid; alignment in TKA; mechanical alignment; kinematic alignment; restricted kinematic alignment; functional alignment; navigation; robotic-assisted surgery; patient-specific instrumentation; additive manufacturing; 3D printing; personalized implant
(This special issue belongs to the Section Orthopedics)
New Insights into Retinal Diseases
edited by Fabio Scarinci and Giulio Pocobelli
submission deadline 20 Apr 2026 | 1 articles | Viewed by 315 | Submission Open
Keywords: optical coherence tomography; optical coherence tomography angiography; vitreoretinal diseases; retinal imaging analysis; biomarkers; segmentation; retinal ischemia; retinal blood flow; choroidal blood flow
(This special issue belongs to the Section Ophthalmology)
Prostate Surgery: The Latest Advances and Future Trends
edited by Akhil K. Das and
submission deadline 20 Apr 2026 | Viewed by 312 | Submission Open
Keywords: benign prostatic hyperplasia (BPH); minimally invasive surgical therapies (MIST); laser enucleation (HoLEP; ThuLEP); Aquablation; Rezum; robotic prostatectomy; anatomic enucleation
(This special issue belongs to the Section Nephrology & Urology)
Clinical Research on Pulmonary Hypertension and Its Complications
edited by Gabor G. Kovacs and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 289 | Submission Open
Keywords: pulmonary hypertension; PH; pulmonary arterial pressure; different diagnostic; therapeutic challenges
(This special issue belongs to the Section Respiratory Medicine)
Clinical Updates and Perspectives on Transcranial Magnetic Stimulation (TMS)—2nd Edition submission deadline 20 Apr 2026 | Viewed by 260 | Submission Open
Keywords: non-invasive brain stimulation; transcranial magnetic stimulation; motor cortex; neuroplasticity; motor learning; dementia; stroke; movement disorders; depression; spinal cord; neuropsychiatric disorders
(This special issue belongs to the Section Clinical Neurology)
Advances in Oculoplastic Surgery: From Eyelid Reconstruction to Innovative Techniques
edited by Argyrios Tzamalis
submission deadline 20 Apr 2026 | Viewed by 231 | Submission Open
Keywords: oculoplastic surgery; eyelid reconstruction; orbital surgery; novel minimally invasive; image guided
Interventional Ultrasound Associated with Rehabilitation in the Treatment of Muscolo-Skeletal Disease
edited by Stefano Galletti and
submission deadline 20 Apr 2026 | Viewed by 215 | Submission Open
Keywords: ultrasound; infiltrative treatment; musculoskeletal imaging; rehabilitation; orthopedic; rheumatology; interventional ultrasound
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Global Expert Views on Aortic Valve Repair and Replacement: 2nd Edition submission deadline 20 Apr 2026 | Viewed by 194 | Submission Open
Keywords: aortic valve pathologies; minimally invasive approach; aortic valve repair; aortic valve replacement; imaging techniques
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Musculoskeletal Pain submission deadline 20 Apr 2026 | Viewed by 153 | Submission Open
Keywords: musculoskeletal pain; chronic pain; primary musculoskeletal pain; secondary chronic musculoskeletal pain; multi-disciplinary pain treatment; imaging in interventional pain management
(This special issue belongs to the Section Orthopedics)
The Latest Research on Male Infertility
edited by Gianmaria Salvio and Nicola delli Muti
submission deadline 20 Apr 2026 | Viewed by 145 | Submission Open
Keywords: idiopathic male infertility; unexplained male infertility; semen quality; testicular dysfunction; male hypogonadism; gonadal failure
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Advances and Challenges in Head and Neck Reconstructive Surgery
edited by , and Luca Calabrese
submission deadline 20 Apr 2026 | Viewed by 132 | Submission Open
Keywords: reconstructive surgery; head and neck; innovation; microsurgery; virtual surgical planning; 3D-printed implants; tissue engineering
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Schizophrenia and Psychotic Disorders: Clinical Updates submission deadline 20 Apr 2026 | Viewed by 129 | Submission Open
Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities
(This special issue belongs to the Section Mental Health)
Pharmacotherapy of Mental Diseases: Latest Developments submission deadline 20 Apr 2026 | Viewed by 126 | Submission Open
Keywords: brain stimulation; mental health; novel intervention; pharmacotherapy; psychotherapy; quality of life; psychologi-cal well-being; treatment personalization in mental diseases
(This special issue belongs to the Section Mental Health)
Clinical Management for Anesthesia Critical Care
edited by Gianluca Zani
submission deadline 20 Apr 2026 | Viewed by 126 | Submission Open
Keywords: anesthesia; critical care medicine; clinical management; critically ill patients; organ failure; organ dysfunction; per-sonalized therapy; outcome; technical skills; non-technical skills
(This special issue belongs to the Section Anesthesiology)
Advances in the Management of Pediatric Neuromuscular Diseases
edited by Nicolas Deconinck
submission deadline 20 Apr 2026 | Viewed by 126 | Submission Open
Keywords: pediatric neuromuscular diseases; neuromuscular disorders (NMD); pediatric; genetic NMD; juvenile myasthenia gravis; chronic demyelinating polyneuropathy; next generation sequencing (NGS); spinal muscular atrophy; Duchenne muscular dystrophy; clinical guidelines
(This special issue belongs to the Section Clinical Neurology)
Vertebral Fractures and Spinal Cord Injury: Advances in Management
edited by and Martin Stangenberg
submission deadline 20 Apr 2026 | Viewed by 125 | Submission Open
Keywords: fracture management; spinal cord injuries; artificial intelligence; machine learning; spinal trauma
(This special issue belongs to the Section Orthopedics)
Up-to-Date Orthopedic Treatment and Care for Osteoporotic Fracture of the Elderly submission deadline 20 Apr 2026 | Viewed by 124 | Submission Open
Keywords: osteoporotic fractures; elderly patients; orthopedic surgery; minimally invasive techniques; fracture rehabilitation; kyphoplasty
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Endodontic Dentistry submission deadline 20 Apr 2026 | Viewed by 124 | Submission Open
Keywords: antimicrobial agents; biofilm; confocal laser scanning microscopy; endodontic materials; irrigants; microbiome; micro-CT; regenerative endodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Heart Failure: Treatment and Clinical Perspectives
edited by Geza Halasz, Domenico Gabrielli and Francesco Grigioni
submission deadline 20 Apr 2026 | Viewed by 122 | Submission Open
Keywords: heart failure; chronic heart failure; acute heart failure; treatment; cardiac imaging; diagnostics; patient outcomes; prognosis
(This special issue belongs to the Section Cardiology)
Novel Advances in Lower Limb Trauma and Orthopaedic Surgery
edited by Konstantinos Tsikopoulos and
submission deadline 20 Apr 2026 | Viewed by 121 | Submission Open
Keywords: lower limb orthopedic surgery; trauma; infection; research
(This special issue belongs to the Section Orthopedics)
New Insights in Joint Arthroplasty—2nd Edition
edited by
submission deadline 20 Apr 2026 | Viewed by 115 | Submission Open
Keywords: total hip arthroplasty; total knee arthroplasty; robotic-assisted technology and navigation; modern implant materials; modern implant fixation techniques; alignment in TKA; spinopelvic alignment in THA
(This special issue belongs to the Section Orthopedics)
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