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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era

edited by

Georgios I. Tagarakis

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9487 | Submission Open

Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Therapy of Trauma and Surgical Critical Care

edited by Rabail Chaudhry and George W. Williams

submission deadline 30 Nov 2025 | 2 articles | Viewed by 8069 | Submission Open

Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations

(This special issue belongs to the Section Intensive Care)

Recent Progress in Rehabilitation Medicine—3rd Edition

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7828 | Submission Open

Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life

(This special issue belongs to the Section Clinical Rehabilitation)

Ischemic Stroke: Diagnosis and Treatment

edited by

Theodoros Karapanayiotides

and

Ioanna Koutroulou

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7340 | Submission Open

Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy

(This special issue belongs to the Section Clinical Neurology)

New Insights into Cardiovascular and Minimally Invasive Cardiac Surgery

edited by Parwis Massoudy and Hilmar C. Dörge

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7281 | Submission Open

Keywords: coronary artery bypass grafting; aortic valve surgery; mitral valve surgery; aortic surgery; minimally invasive cardiac surgery

(This special issue belongs to the Section Cardiology)

Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches

edited by Elisabeth M.J.P. Mouws and

Natasja de Groot

submission deadline 30 Nov 2025 | 5 articles | Viewed by 6666 | Submission Open

Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases

edited by Sotiria Palioura, Carolina L. Mercado and

Jaime D. Martinez

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5422 | Submission Open

Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques

(This special issue belongs to the Section Ophthalmology)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by

Alfredo Papa

and Loris Riccardo Lopetuso

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4278 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3631 | Submission Open

Keywords: heart; lung; kidney; liver; bone; brain

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Advances of Breast Surgery and Reconstruction

edited by

Glenda Giorgia Caputo

and Emanuele Cigna

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2038 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Novel Aspects of Endocrine Care: From Patient-Centred Management of Endocrine Diseases to Guidelines Standards

edited by

Mara Carsote

and

Claudiu Nistor

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1932 | Submission Open

Keywords: endocrine tumour; hormone; biomarker; neuroendocrine tumour; thyroidectomy; parathyroidectomy; bone; ad-renal gland; osteoporosis; pituitary gland; autoimmune; antibody; clinical study; computed tomography

(This special issue belongs to the Section Endocrinology & Metabolism)

Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer

edited by Bhaumik Patel

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1677 | Submission Open

Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthodontics: State of the Art and Prospects

edited by Beatriz Tarazona-Álvarez and

Natalia Zamora-Martínez

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1537 | Submission Open

Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Thoracic Surgery Between Tradition and Innovations

edited by Jacopo Vannucci

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1359 | Submission Open

Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy

(This special issue belongs to the Section General Surgery)

Multiparametric Ultrasound Techniques for Liver Disease Assessments

edited by Francesco Giangregorio

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1274 | Submission Open

Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Orthopedic Surgery: Latest Advances and Perspectives

edited by

Mitchell K. Ng

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1126 | Submission Open

Keywords: motion preservation; pain management; robotics/computer navigation; degenerative disc disease; orthobiologics; arthroplasty; trauma

(This special issue belongs to the Section Orthopedics)

Current Challenges in Orthopedic Trauma Surgery

edited by Pietro Maniscalco and Fabrizio Quattrini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1102 | Submission Open

Keywords: hip replacement; knee replacement; shoulder replacement; ankle replacement; trauma surgery; femur; future chal-lenges; surgical innovations

(This special issue belongs to the Section Orthopedics)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 30 Nov 2025 | 1 articles | Viewed by 964 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Spine Surgery Innovations: Clinically Advanced Treatment and Technologies

edited by Jang W. Yoon

submission deadline 30 Nov 2025 | 1 articles | Viewed by 942 | Submission Open

Keywords: minimally invasive spine surgery; artificial intelligence; wearable biometrics; big data; smartphone accelerometer

(This special issue belongs to the Section Orthopedics)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 30 Nov 2025 | Viewed by 877 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities

edited by

Gian Marco Prucher

Andrea Cassoni

and Francesco Arcuri

submission deadline 30 Nov 2025 | 1 articles | Viewed by 516 | Submission Open

Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Anesthesia and Perioperative Management of Organ Transplants

edited by

Uzung Yoon

and Ji-Hye Kwon

submission deadline 30 Nov 2025 | Viewed by 287 | Submission Open

Keywords: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension

(This special issue belongs to the Section Anesthesiology)

Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care

edited by

Keiichi Hirono

submission deadline 30 Nov 2025 | Viewed by 283 | Submission Open

Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging

(This special issue belongs to the Section Cardiology)

Challenges in the Diagnosis and Treatment of Glaucoma

edited by

Abdelaziz Abdelaal

submission deadline 30 Nov 2025 | Viewed by 245 | Submission Open

Keywords: glaucoma diagnosis; glaucoma progression; glaucoma biomarkers; intraocular pressure (IOP) management; corneal hysteresis; machine learning in glaucoma detection; neuroprotection in glaucoma; surgery and laser therapy

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest

edited by

Erik Roman-Pognuz

submission deadline 30 Nov 2025 | Viewed by 218 | Submission Open

Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Minimally Invasive Gastrointestinal Surgery: Clinical Advances and Prospects

edited by Jun Suh Lee

submission deadline 30 Nov 2025 | Viewed by 209 | Submission Open

Keywords: minimally invasive surgery; gastrointestinal surgery; laparoscopic surgery; robotic surgery; surgical innovation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Role of Platelet in Inflammation, Infection, and Immune Response

edited by

Amir Houshang Shemirani

submission deadline 30 Nov 2025 | Viewed by 193 | Submission Open

Keywords: platelets; platelet count; dual antiplatelet therapy; inflammation; thrombosis; inflammation; hemostasis; immune response

(This special issue belongs to the Section Hematology)

Interventional Cardiology: Clinical Advances and Future Perspectives

edited by Antonio Landi and

Andrea Milzi

submission deadline 30 Nov 2025 | Viewed by 189 | Submission Open

Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome

(This special issue belongs to the Section Cardiology)

Technology and Innovations in Microsurgical Reconstruction: Bridging Challenges in Breast, Lymphatic, and Limb Reconstruction

edited by Gordon K. Lee,

Dung Nguyen

and

Sik Namgoong

submission deadline 30 Nov 2025 | Viewed by 181 | Submission Open

Keywords: microsurgery; breast reconstruction; limb reconstruction; perforator flaps; super microsurgery; surgical innovation; reconstructive surgery; lymphedema; tissue engineering; diabetic foot reconstruction; wound healing; cell therapy

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Novel Insights into the Clinical Management of Retinal Detachment

edited by Francesco Sabatino

submission deadline 30 Nov 2025 | Viewed by 157 | Submission Open

Keywords: retinal detachment; oil toxicity; gas tamponade; pars plana vitrectomy; scleral buckle; pneumatic retinopexy; surgical techniques; retinal imaging; retinal displacement

(This special issue belongs to the Section Ophthalmology)

Kidney Transplantation: Recent Advances and Challenges

edited by Jose Torrealba

submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open

Keywords: kidney allograft; pathology; HLA and antibodies; management

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in the Management and Treatment of Obesity

edited by

Francesca Battista

submission deadline 5 Dec 2025 | 1 articles | Viewed by 4615 | Submission Open

Keywords: obesity; therapy; weight loss; diet; surgery; exercise; personalized medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

AI in Maternal Fetal Medicine and Perinatal Management

edited by Ariel Many

submission deadline 5 Dec 2025 | 2 articles | Viewed by 3641 | Submission Open

Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction

(This special issue belongs to the Section Obstetrics & Gynecology)

Comprehensive Approaches in Plastic and Reconstructive Surgery

edited by Michael Alfertshofer

submission deadline 7 Dec 2025 | 4 articles | Viewed by 6247 | Submission Open

Keywords: plastic surgery; reconstructive surgery; regenerative medicine; advanced surgical planning; trauma reconstruction; patient-specific solutions; multidisciplinary care

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Challenges in Obstetrics and Gynecology: Interactions Between Gynecological and Obstetric Disorders, Quality of Life, and Mental Health in Women

edited by

Ernesto González-Mesa

and Daniel María Lubián López

submission deadline 10 Dec 2025 | 7 articles | Viewed by 9654 | Submission Open

Keywords: perinatal mental health; gynecological disorders; sexual disorders; women’ s quality of life; obstetric complications; women’ s health; women’ s psychological well-being

(This special issue belongs to the Section Obstetrics & Gynecology)

State of the Art: Updates in Preterm Labor and Preterm Birth

edited by

Eran Bornstein

and Moti Gulersen

submission deadline 10 Dec 2025 | 5 articles | Viewed by 8536 | Submission Open

Keywords: prenatal diagnosis; preterm birth; antenatal corticosteroids; cerclage; multiple gestations

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in the Prevention, Diagnosis, and Rehabilitation of Sports Injuries

edited by Kevin Laudner

submission deadline 10 Dec 2025 | 3 articles | Viewed by 6389 | Submission Open

Keywords: orthopedics; prevention; rehabilitation; management; sports injuries

(This special issue belongs to the Section Sports Medicine)

Cardiac Arrhythmias: Current Status and Future Directions

edited by

Jackson J. Liang

submission deadline 10 Dec 2025 | 1 articles | Viewed by 5617 | Submission Open

Keywords: ventricular tachycardia; atrial fibrillation; catheter ablation; novel therapies; complex arrhythmias

(This special issue belongs to the Section Cardiology)

Kidney Transplantation and Rehabilitation: Current Updates and Perspectives

edited by Zoltán Sándor

submission deadline 10 Dec 2025 | 3 articles | Viewed by 5215 | Submission Open

Keywords: chronic kidney disease; kidney transplantation; transplant rehabilitation; transplant care; physical therapy; occupational therapy; intervention; recovery; quality of life; aftercare

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in Arthroscopic Shoulder Surgery

edited by Anup Ajit Shah, Michael J. O’Brien and Asheesh Bedi

submission deadline 10 Dec 2025 | 1 articles | Viewed by 668 | Submission Open

Keywords: rotator cuff; biologic tuberoplasty; lower trapezius tendon transfer; arthroscopic Latarjet; arthroscopic bone block; augmentation of the cuff

(This special issue belongs to the Section Orthopedics)

Latest Research on Male Infertility

edited by

Manesh Kumar Panner Selvam

submission deadline 10 Dec 2025 | Viewed by 505 | Submission Open

Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Innovative Endodontics

edited by

Federico Foschi

submission deadline 10 Dec 2025 | Viewed by 157 | Submission Open

Keywords: regenerative endodontics; bioceramics; guided endodontics; AI in endodontics; pericervical dentine; reduced taper; irrigation adjuvant; pulp regeneration

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates on Geriatric Oncology

edited by Cherif N. Boutros

submission deadline 12 Dec 2025 | Viewed by 153 | Submission Open

Keywords: geriatric oncology; cancer in elderly; geriatric cancer care; frailty; access to cancer care

(This special issue belongs to the Section Geriatric Medicine)

Physical Activity, Exercise and Health: Clinical Management and Research

edited by

Do-yeon Kim

Dae Yun Seo

and

Ju-yong Bae

submission deadline 15 Dec 2025 | 9 articles | Viewed by 12383 | Submission Open

Keywords: physical activity; exercise; exercise physiology; exercise prescription; aging; women’ s health; chronic disease

(This special issue belongs to the Section Epidemiology & Public Health)

Recent Advances in the Management of Fractures

edited by Giulio Maccauro and

Raffaele Vitiello

submission deadline 15 Dec 2025 | 7 articles | Viewed by 9801 | Submission Open

Keywords: trauma; fractures; prosthesis; megaprosthesis; modular prosthesis; plate; nail; combo; screw; rehabilitation; radiology

(This special issue belongs to the Section Orthopedics)

Coronary Heart Disease: Causes, Diagnosis and Management

edited by

Andrea Denegri

submission deadline 15 Dec 2025 | 3 articles | Viewed by 8397 | Submission Open

Keywords: coronary heart disease; coronary revascularization; coronary artery disease; ischemic heart disease; atherosclerosis

(This special issue belongs to the Section Cardiology)

Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come

edited by Dirk Stengel and

Paul Alfred Grützner

submission deadline 15 Dec 2025 | 5 articles | Viewed by 8252 | Submission Open

Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries

(This special issue belongs to the Section Orthopedics)

Aortic Pathologies: Aneurysm, Atherosclerosis and More

edited by Alexander Gombert and Panagiotis Doukas

submission deadline 15 Dec 2025 | 4 articles | Viewed by 7673 | Submission Open

Keywords: aorta; aortic aneurysm; thoracoabdominal aortic aneurysm; fenestrated endovascular aortic repair (FEVAR); branched endovascular aortic repair (BEVAR); spinal cord ischemia; coral reef aorta; surgery; endovascular aortic surgery

(This special issue belongs to the Section Cardiovascular Medicine)

Spine Surgery: Clinical Advances and Future Directions

edited by

Seung-kook Kim

and Eun-Sang Kim

submission deadline 15 Dec 2025 | 4 articles | Viewed by 7542 | Submission Open

Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain

(This special issue belongs to the Section Clinical Neurology)

Neural Application of Artificial Intelligence in Clinical Neuroscience

edited by Saurabh J. Singhal

submission deadline 15 Dec 2025 | 3 articles | Viewed by 4694 | Submission Open

Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction

(This special issue belongs to the Section Clinical Neurology)

Displaying special issue 51-100 on page 2 of 32.

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