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Latest Research on Male Infertility

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Reproductive Medicine & Andrology".

Deadline for manuscript submissions: 5 June 2026 | Viewed by 925

Special Issue Editor


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Guest Editor
Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA
Interests: reproductive medicine; sperm and seminal plamsa proteomics; applied bioinformatics; telomere signaling pathway; seminal exosome dysfunction; COVID and male reproduction; andrology; sperm DNA damage; seminal oxidative stress; testicular cancer; varicocele
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Special Issue Information

Dear Colleagues,

Male factor issues are responsible for 50% of a couple’s infertility. Male infertility is emerging as an important cause of infertility worldwide, and recent research has improved our understanding of the sperm’s contribution to fertilization and embryo development. New insights into sperm function and fertilization have been uncovered, emphasizing the need for breakthroughs to assist sperm during successful fertilization. This involves understanding the sperm’s ability to navigate the female reproductive tract and overcome biological barriers​. Continued research in these areas promises to improve diagnostic and treatment options for affected individuals. This Special Issue on “Latest Research on Male Infertility” will feature the articles related to male reproductive research advancements, with insights identified at the molecular level. For this Special Issue, we invite you and your colleagues to submit an original research article or comprehensive review article related to this field.

Dr. Manesh Kumar Panner Selvam
Guest Editor

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Keywords

  • testis
  • sperm
  • seminal plasma
  • spermatogenesis
  • fertilization
  • omics
  • proteomics
  • oxidative stress
  • sperm DNA fragmentation
  • varicocele
  • male infertility
  • testicular cancer
  • infertility management
  • ART

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Published Papers (1 paper)

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Research

13 pages, 253 KB  
Article
Sperm DNA Fragmentation in Normozoospermic Men Is Associated with Blastocyst Formation and Quality in Conventional In Vitro Fertilization
by Yusaku Mori, Linji Chen, Shogo Nishii, Miwa Sakamoto, Makoto Ohara, Akihiko Sekizawa and Sho-Ichi Yamagishi
J. Clin. Med. 2025, 14(24), 8892; https://doi.org/10.3390/jcm14248892 - 16 Dec 2025
Viewed by 324
Abstract
Background: Assisted reproductive therapy (ART) has been utilized as an effective therapeutic strategy for addressing infertility worldwide, and one of the key determinants of ART success is the acquisition of high-quality embryos through in vitro fertilization (IVF). We investigated which male factors [...] Read more.
Background: Assisted reproductive therapy (ART) has been utilized as an effective therapeutic strategy for addressing infertility worldwide, and one of the key determinants of ART success is the acquisition of high-quality embryos through in vitro fertilization (IVF). We investigated which male factors were associated with embryo formation and quality in conventional IVF (cIVF). Methods: This study was an exploratory subanalysis of a trial conducted to examine the associations of clinical and lifestyle factors with sperm abnormalities in 41 men from infertile couples without identifiable male factors. From the original cohort, 21 men whose partners underwent cIVF were included for blastocyte outcome assessment. Semen samples were evaluated for standard sperm parameters and DNA fragmentation index (DFI). Blood biochemical parameters and lifestyle habits were also evaluated. Blastocysts were assessed 5 days after cIVF, and implantation success was determined 10 days after embryo transfer. Results: All participants showed normozoospermia, with mild sperm DFI in 76%. Blastocysts were formed in 32% of the oocytes following cIVF, with good blastocyst development and quality observed in 71% and 39%, respectively. The implantation success and live birth rates after embryo transfer were 53% and 43%, respectively. Regression analysis identified sperm DFI as the only variable inversely associated with all blastocyst outcomes. In contrast, no parameters were associated with implantation success or live birth rates. Conclusions: The present subanalysis suggests the hypothesis that sperm DNA fragmentation may be negatively associated with high-quality embryo formation in cIVF, even among normozoospermic men with non-severe levels of sperm DFI. Full article
(This article belongs to the Special Issue Latest Research on Male Infertility)
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