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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiac Arrest Research: Neuroprognostication and Improving Outcomes

edited by

Jae Hoon Lee

and Jin-hong Min

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1027 | Submission Open

Keywords: cardiac arrest; prognosis; hypothermia; induced; resuscitation; magnetic resonance imaging; electroencephalography; blood pressure; hypoxia-ischemia; brain; extracorporeal membrane oxygenation

(This special issue belongs to the Section Cardiovascular Medicine)

Idiopathic Pulmonary Fibrosis (IPF): Current Perspectives and Future Directions

edited by Vito D’Agnano

submission deadline 20 Jan 2026 | 1 articles | Viewed by 955 | Submission Open

Keywords: pulmonary fibrosis; IPF; ILD; antifibrotics; EMT; respiratory physiology; metabolism

(This special issue belongs to the Section Respiratory Medicine)

Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

edited by Ivan Krečak, Marko Skelin and Zinaida Perić

submission deadline 20 Jan 2026 | 1 articles | Viewed by 946 | Submission Open

Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis

(This special issue belongs to the Section Hematology)

New Perspectives in Chronic Kidney Disease, Transplantation and Immune System

edited by

Maria Daoudaki

and Dimitrios A. Tsakiris

submission deadline 20 Jan 2026 | 1 articles | Viewed by 901 | Submission Open

Keywords: kidney transplantation; HLA; matching at the epitope level; DSAs; complement; kidney disease epigenetics; diabetic nephropathy; hemostasis; graft rejection; B and T cell immunophenotyping; end stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Artificial Intelligence (AI) in Dental Clinical Practice

edited by

Eiji Tanaka

and Keiichiro Watanabe

submission deadline 20 Jan 2026 | 1 articles | Viewed by 846 | Submission Open

Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Practice and Future Perspectives on Laryngeal Surgery

edited by

Eugenia Allegra

and

Maria Rita Bianco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 835 | Submission Open

Keywords: laryngeal disorders; laryngeal surgery; microsurgery; endoscopic surgery; open surgery; laser surgery

(This special issue belongs to the Section Otolaryngology)

Rehabilitation and Treatment of Post-COVID-19 Condition

edited by

Indre Bileviciute-Ljungar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 768 | Submission Open

Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work

(This special issue belongs to the Section Clinical Rehabilitation)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

Multiple Myeloma: Therapeutic and Management Strategies

edited by Terri Parker

submission deadline 20 Jan 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management

(This special issue belongs to the Section Hematology)

Obesity-Related Metabolic and Cardiovascular Disorders

edited by

Lucia Frittitta

and Federica Vinciguerra

submission deadline 20 Jan 2026 | 1 articles | Viewed by 672 | Submission Open

Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Prenatal Diagnosis and Fetal Therapy

edited by

Mar Bennasar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 618 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiac and Pulmonary Involvements in High-Risk Neonatal Cohorts: Short- and Long-Term Issues

edited by Arvind Sehgal

submission deadline 20 Jan 2026 | 1 articles | Viewed by 590 | Submission Open

Keywords: fetal growth restriction; lung disease; cardiac maladaptation; placenta; public health; neurodevelopment; long term; adulthood; Barker’ s hypothesis; newborn; vascular

(This special issue belongs to the Section Clinical Pediatrics)

Cardiopulmonary Resuscitation in the Emergency Care Unit

edited by

Martín Otero-Agra

, Felipe Fernández-Méndez,

Myriam Santos-Folgar

and

María Fernández-Méndez

submission deadline 20 Jan 2026 | 1 articles | Viewed by 509 | Submission Open

Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit

(This special issue belongs to the Section Emergency Medicine)

Current Status and Future of Urological Surgery

edited by

Filippo Marino

, Davide De Marchi and

Luca Di Gianfrancesco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: urological surgery; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; augmented reality; surgical navigation; endourology; laparoscopic urology; reconstructive urology; functional urology; bph treatment; urinary incontinence; prostate cancer surgery; bladder cancer surgery; surgical innovation; digital surgery

(This special issue belongs to the Section Nephrology & Urology)

Clinical Comparisons of Nonpharmaceutical and Pharmaceutical Analgesia

edited by

Sang Hun Kim

and

Yoon Ji Choi

submission deadline 20 Jan 2026 | Viewed by 381 | Submission Open

Keywords: acute pain; chronic pain; postoperative pain; non-pharmaceutical; pharmaceutical; analgesia; clinical

(This special issue belongs to the Section Anesthesiology)

Shaping Modern Gastroenterology: Bridging Advancements in Digestive Endoscopy and Clinical Research

edited by Manuele Furnari and Stefano Kayali

submission deadline 20 Jan 2026 | Viewed by 363 | Submission Open

Keywords: digestive endoscopy; gastrointestinal disorders; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); therapeutic endoscopy; artificial intelligence; pancreatic and biliary diseases; small bowel pathology; early neoplastic lesions; inflammatory bowel diseases (IBDs); translational gastroenterology; endoscopic submucosal dissection (ESD); per-oral endoscopic myotomy (POEM); endoscopic imaging; gastrointestinal pathophysiology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome

edited by

Maria Amicone

and

Antonio Pisani

submission deadline 20 Jan 2026 | Viewed by 339 | Submission Open

Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet

(This special issue belongs to the Section Nephrology & Urology)

Clinical Updates and Current Challenges in Obstetrical Anesthesia

edited by Michael Froelich

submission deadline 20 Jan 2026 | Viewed by 286 | Submission Open

Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care

(This special issue belongs to the Section Obstetrics & Gynecology)

Metabolic Dysregulation Across the Spectrum from Anorexia Nervosa to Obesity

edited by Andriana C. Kaliora

submission deadline 20 Jan 2026 | Viewed by 275 | Submission Open

Keywords: metabolic dysregulation; anorexia nervosa; obesity; environmental factors in metabolic health; gut microbiota and metabolism; hormonal regulation of appetite; inflammation and metabolic disorders; dietary influence on metabolism

(This special issue belongs to the Section Endocrinology & Metabolism)

Innovations and Evolution of Extracorporeal Organ Support in Critical Care

edited by

Francesco Alessandri

Giovanni Giordano

and Antonella Tosi

submission deadline 20 Jan 2026 | Viewed by 253 | Submission Open

Keywords: critical care; extracorporeal organ support; critical care nephrology; cardiology; ARDS; sepsis; blood purification; liver support

(This special issue belongs to the Section Intensive Care)

Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)

edited by Diana Alecsandru

submission deadline 20 Jan 2026 | Viewed by 228 | Submission Open

Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Bronchoscopy and Interventional Pulmonology

edited by Bryan S. Benn and

Jonathan Kurman

submission deadline 20 Jan 2026 | Viewed by 225 | Submission Open

Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction

(This special issue belongs to the Section Respiratory Medicine)

Haemophilia: Current Treatment and Clinical Outcomes, Challenges and Opportunities: 2nd Edition

edited by

Ezio Zanon

submission deadline 20 Jan 2026 | Viewed by 220 | Submission Open

Keywords: haemophilia A and B; FVIII EHL; FIX EHL; prophylaxis; emicizumab; health-related quality of life; population pharmacokinetics

(This special issue belongs to the Section Hematology)

From Dual Diagnosis to Dual Disorder(s): Bridging Comorbidity and Integrated Clinical Understanding

edited by

Angelo Giovanni Icro Maremmani

submission deadline 20 Jan 2026 | Viewed by 203 | Submission Open

Keywords: dual diagnosis; dual disorder; psychiatric comorbidity; addiction; integrated care; self-medication; substance use; mental illness; treatment models

(This special issue belongs to the Section Mental Health)

Clinical Application of Echocardiography in Heart Disease: 2nd Edition

edited by

Carlos Cotrim

submission deadline 20 Jan 2026 | Viewed by 161 | Submission Open

Keywords: transthoracic echocardiography; transesophageal echocardiography; stress echocardiography; valve disease; coronary artery disease; myocardial disease; pericardial disease; aortic disease; congenital heart disease

(This special issue belongs to the Section Cardiology)

Preventive Strategies and Novel Treatments for Rheumatoid Arthritis

edited by

Vincent Goeb

submission deadline 20 Jan 2026 | Viewed by 156 | Submission Open

Keywords: rheumatoid arthritis; antibodies; biologics; JAK; environment; susceptibility; therapeutic strategies

(This special issue belongs to the Section Immunology & Rheumatology)

Recent Advances and Future Perspectives of Subarachnoid Hemorrhage

edited by Alexandros Doukas and Athanasios K. Petridis

submission deadline 20 Jan 2026 | Viewed by 156 | Submission Open

Keywords: subarachnoid hemorrhage; neuromonitoring; neurocritical care; neurointerventions; neurointensive care

(This special issue belongs to the Section Clinical Neurology)

New Insights in Trauma and Emergency Surgery

edited by Kai Oliver Jensen and Valentin Neuhaus

submission deadline 20 Jan 2026 | Viewed by 153 | Submission Open

Keywords: trauma and emergency surgery; multiple trauma; orthopedic trauma; surgery; concepts in trauma

(This special issue belongs to the Section Emergency Medicine)

Emerging Trends in Multiple Myeloma

edited by

Despina Fotiou

submission deadline 20 Jan 2026 | Viewed by 150 | Submission Open

Keywords: multiple myeloma; personalized medicine; high-risk disease; cellular therapies; refractory disease

(This special issue belongs to the Section Hematology)

Recent Management of Hip Fractures

edited by

Toshiyuki Kawai

submission deadline 20 Jan 2026 | Viewed by 149 | Submission Open

Keywords: hip fracture; internal fixation; hemiarthroplasty; arthroplasty and fixation; osteoporosis management; fracture prevention; multidisciplinary care; surgical treatment; rehabilitation strategies

(This special issue belongs to the Section Orthopedics)

Current Trends and Future Challenges in Heart Failure

edited by Oren Caspi and

Robert Zukermann

submission deadline 20 Jan 2026 | Viewed by 143 | Submission Open

Keywords: heart failure; guideline-directed therapy; digital health; biomarkers; multidisciplinary care; artificial intelligence; cardiorenal syndrome; remote hemodynamic monitoring; cardiac amyloidosis; exercise rehabilitation

(This special issue belongs to the Section Cardiology)

Advances in Chronic Pain Research and Therapy

edited by Elena Makovac

submission deadline 20 Jan 2026 | Viewed by 141 | Submission Open

Keywords: chronic pain; pain perception; brain-body interactions; therapeutic effectiveness; integrated approach

(This special issue belongs to the Section Clinical Rehabilitation)

Therapeutic Strategies for Obesity and Diabetes in Cardiovascular Disease Patients

edited by Davide D'Andrea

submission deadline 20 Jan 2026 | Viewed by 139 | Submission Open

Keywords: obesity; diabetes; cardiovascular complications; diabetes management; pharmacological treatment; bariatric surgery; regular monitoring

(This special issue belongs to the Section Cardiovascular Medicine)

Lung Transplantation: Current Challenges and New Perspectives

edited by Reinaldo E. Rampolla and Pedro A. Catarino

submission deadline 20 Jan 2026 | Viewed by 131 | Submission Open

Keywords: lung transplantation; interstitial lung diseases; pulmonary hypertension; chronic obstructive pulmonary disease; bronchiectasis; extra corporeal membrane oxygenation; robotic lung transplantation

(This special issue belongs to the Section Respiratory Medicine)

Clinical Update on Aortic Valve Disease Treatments

edited by

Giovanni Concistre

submission deadline 20 Jan 2026 | Viewed by 128 | Submission Open

Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation

(This special issue belongs to the Section Cardiology)

Clinical Advances, Opportunities, and Challenges in Digestive Diseases of the Foregut

edited by Valentin Mocanu and

Salvador Navarrete

submission deadline 20 Jan 2026 | Viewed by 120 | Submission Open

Keywords: obesity; achalasia; reflux; malrotation; therapeutic endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Regional Anesthesia in Pain Management

edited by Jaime L. Baratta

submission deadline 20 Jan 2026 | Viewed by 116 | Submission Open

Keywords: acute pain; perioperative medicine; general anesthesiology; regional anesthesia; orthopedic anesthesia; multimodal analgesia

(This special issue belongs to the Section Anesthesiology)

Clinical Advances in Urologic Oncology: 2nd Edition

edited by Saum Ghodoussipour

submission deadline 20 Jan 2026 | Viewed by 111 | Submission Open

Keywords: bladder cancer; kidney cancer; prostate cancer; testis cancer; penile cancer; minimally invasive; cancer treatment

(This special issue belongs to the Section Nephrology & Urology)

New Clinical Perception of Cardiac Rehabilitation

edited by

Antonello D’Andrea

and Mario Pacileo

submission deadline 20 Jan 2026 | Viewed by 110 | Submission Open

Keywords: cardiac rehabilitation; digital health; exercise therapy; cardiovascular prevention; chronic disease management; psychosocial support; personalized medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults

edited by

Roxana Maria Nemes

submission deadline 20 Jan 2026 | Viewed by 109 | Submission Open

Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors

(This special issue belongs to the Section Respiratory Medicine)

Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies

edited by Alessandro Andreis,

Guglielmo Beccuti

and

Angelo Armandi

submission deadline 20 Jan 2026 | Viewed by 105 | Submission Open

Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology

(This special issue belongs to the Section Cardiology)

Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century

edited by Reinhardt T. Grundmann

submission deadline 20 Jan 2026 | Viewed by 102 | Submission Open

Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation

(This special issue belongs to the Section Cardiovascular Medicine)

The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century

edited by Tomer Ziv-Baran and Elena Izkhakov

submission deadline 20 Jan 2026 | Viewed by 100 | Submission Open

Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach

(This special issue belongs to the Section Epidemiology & Public Health)

Macular Diseases: From Diagnosis to Treatment

edited by

Gabriella De Salvo

submission deadline 22 Jan 2026 | Viewed by 201 | Submission Open

Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers

(This special issue belongs to the Section Ophthalmology)

Personalized Radiological and Surgical Strategies for Breast Cancer Treatment

edited by Vlad Alexandru Gata, Maximilian Muntean and

Roxana Pintican

submission deadline 22 Jan 2026 | Viewed by 81 | Submission Open

Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction

(This special issue belongs to the Section General Surgery)

Application of Artificial Intelligence in Cardiology

edited by

Matthias Unterhuber

submission deadline 23 Jan 2026 | 4 articles | Viewed by 3312 | Submission Open

Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning

(This special issue belongs to the Section Cardiology)

Clinical Advances and New Challenges in Laparoscopic Surgery

edited by Ionut Bogdan Diaconescu and Matei Bratu

submission deadline 23 Jan 2026 | Viewed by 105 | Submission Open

Keywords: laparoscopic surgery; trauma surgery; surgical oncology; abdominal surgery; colorectal surgery; general surgery; minimally invasive surgery; gastrointestinal surgery; hernia surgery; surgery; advance laparoscopic surgery; cancer surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Glaucoma: Current Status and Prospects

edited by Rubén Sánchez-Jean,

Carmen Dora Méndez-Hernández

and Federico Sáenz-Francés San Baldomero

submission deadline 24 Jan 2026 | 2 articles | Viewed by 3654 | Submission Open

Keywords: glaucoma surgery; new techniques; minimally invasive glaucoma surgery; intraocular pressure; optometry; IOLs designs

(This special issue belongs to the Section Ophthalmology)

Pediatric Pulmonology: Recent Developments and Emerging Trends

edited by Athina L. Papadopoulou

submission deadline 25 Jan 2026 | 5 articles | Viewed by 17781 | Submission Open

Keywords: definition of breath sounds; lung– gut axis pathophysiology; disease endotypes and phenotypes; asthma management in children; bronchiolitis spectrum; pediatric bronchopulmonary dysplasia; pulmonary function testing in pediatric patients; pediatric sleep-disordered breathing; neonatal respiratory distress syndrome; childhood interstitial lung diseases; pulmonary hypertension in children; biomarkers in pediatric lung diseases; allergy and the lungs; diagnostic and therapeutic challenges in bronchoscopy; gene therapy in cystic fibrosis

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond

edited by

Rosalinda Madonna

submission deadline 25 Jan 2026 | 5 articles | Viewed by 12706 | Submission Open

Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors

(This special issue belongs to the Section Cardiovascular Medicine)

Displaying special issue 401-450 on page 9 of 31.

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